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Aims: Drug–gene interactions (DGIs) modify drug response and safety, yet their influence on diabetic microvascular complications remains unclear. This study aimed to elucidate the role of DGIs in these complications. Materials and Methods: Using UK Biobank (UKB) data, we identified medications frequently prescribed to individuals with diabetes and defined DGIs based on the Food and Drug Administra

Introduction: Suturing is a fundamental component of surgical procedures, wherein training emphasises the significance of gentle tissue handling. The suturing process involves the pressure exerted by the forceps onto the tissue, as well as the medial traction force applied to stabilise the tissue during the needle bite. This study examined the forces involved in tissue handling during suturing, co

Background: Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) are frequently comorbid and are individually associated with increased risk of suicidal behavior. However, whether their comorbidity exacerbates this risk has not been adequately investigated. Methods: Using a Swedish birth cohort (born 1970–1990; N = 799,203–858,983), we employed Aalen’s linear hazards models to evalu

Background: Programmed death-ligand 1 (PD-L1) immunocytochemical (ICC) analysis of cell blocks (CBs) has recently emerged in clinical practice. Unlike standardized immunohistochemistry on formalin-fixed, paraffin-embedded tissues, cytology involves various preparation methods and fixatives. This study investigated how various fixatives influence PD-L1 immunoreactivity in CBs from malignant pleural

GOALS: To assess the incidence, type, and severity of infections in patients with IBD before and after starting thiopurine therapy.BACKGROUND: Thiopurines have been used for decades in the treatment of inflammatory bowel disease (IBD), yet real-world data regarding the extent and types of infections associated with their use are scarce.STUDY: We included all thiopurine-naive adults with IBD who in

Background: We aimed to assess the risk of serious infections in patients with inflammatory bowel disease (IBD) exposed to different advanced therapies. Methods: We linked nationwide registers and compared rates of incident serious infections in patients with Crohn’s disease (CD) and ulcerative colitis (UC) exposed to medical therapies versus matched general population comparators during 2007-2023

BackgroundThe Job Demand–Control–Support (JD-C-S) model evaluates how psychosocial work factors affect health and performance. We examined how demographics, job title, and experience influence demand, control, and support among Ghanaian pharmacy staff.MethodsA cross-sectional survey of pharmacy personnel from Tamale and Sagnerigu was conducted using the JD-C-S questionnaire. Demand and control ite

https://www.sustainability.lu.se/sites/sustainability.lu.se/files/2021-01/syllabus_sustainability_science_and_the_sdgs_75credits_20201104.pdf - 2026-05-29

Detecting potential outliers in longitudinal data with time-dependent covariates ARTICLE Detecting potential outliers in longitudinal data with time-dependent covariates Lazarus K. Mramba 1✉, Xiang Liu1, Kristian F. Lynch1, Jimin Yang 1, Carin Andrén Aronsson 2,3, Sandra Hummel4, Jill M. Norris5, Suvi M. Virtanen6,7,8,9, Leena Hakola8,9, Ulla M. Uusitalo 1 and Jeffrey P. Krischer1 © The Author(s),

https://www.teddy.lu.se/sites/teddy.lu.se/files/2024-04/162_MP286_Mramba_EJCN_2024.pdf - 2026-05-29

OBJECTIVES: Hypertension and diabetes are common and are both associated with high cardiovascular morbidity and mortality. We aimed to investigate associations between mortality risk and country of birth among hypertensive individuals in primary care with and without concomitant diabetes, which has not been studied previously. In addition, we aimed to study the corresponding risks of myocardial in

Background: Total pancreatectomy has high morbidity and mortality and differences among countries are currently unknown. This study compared the use and postoperative outcomes of total pancreatectomy among 4 Western countries. Methods: Patients who underwent one-stage total pancreatectomy were included from registries in the United States, Germany, the Netherlands, and Sweden (2014–2018). Use of t

Objective. Ankylosing spondylitis (AS) is associated with an elevated risk of cardiovascular disease (CVD) related to atherosclerosis, preceded by arterial stiffness. We aimed to examine common carotid artery (CCA) biomechanical properties using ultrasound to calculate β stiffness index (indicating arterial stiffness) and, a more recently developed technique, 2-dimensional (2D) speckle tracking st

In 2016, we reported the presence of Plasmodium vivax in Botswana through active case detection. A realtime PCR was used during a similar study in 10 districts to assess changes in the P. vivax prevalence. We assessed 1,614 children (2-13 years of age) for hemoglobin (Hb; g/dL) and Plasmodium parasites. The median age of all participants was 5.0 years (25th percentile, 3 years; 75th percentile, 8

Research area PI E-mail address 1 Autoimmunity Dan Holmberg, professor Dan.holmberg@med.lu.se 2 Cardiology/Cardiovascular Research, translational studies Isabel Goncalves, professor Isabel.goncalves@med.lu.se 2 Cellular Autoimmunity Corrado Cilio, professor Corrado.cilio@med.lu.se 3 Centre for Analyses and Synthesis Peter Spégel, docent Peter.spegel@med.lu.se 5 Diabetes and Brain function João Dua

https://www.ludc.lu.se/sites/ludc.lu.se/files/2021-02/LUDC_PIs_210226.pdf - 2026-05-29

Rights-Based Climate Adaptation in Armenia and Georgia, 2024-2025 Rights-Based Climate Adaptation in Armenia and Georgia LUND UNIVERSITY | 2024-2025 This call invites public sector professionals working in areas relating to climate change adaptation, disaster risk reduction, sustainable development, human rights and gender equality to apply to join an innovative Lund University certificate course

https://www.lunduniversity.lu.se/sites/www.lunduniversity.lu.se/files/2024-02/Rights-based-climate-adaptation-in-armenia-and-georgia-2024-2025.pdf - 2026-05-29

AimsAtrial septal defects (ASDs) lead to volume-loaded right ventricles (RVs). ASD closure does not always alleviate symptoms or improve exercise capacity, which is possibly explained by impaired left ventricular (LV) haemodynamics. This study evaluated the effect of ASD closure in children using non-invasive LV pressure–volume (PV) loops derived from cardiac magnetic resonance (CMR) imaging and b

OBJECTIVES: To identify multimorbidity trajectories over 20 years among incident osteoarthritis (OA) individuals and OA-free matched references.METHODS: Cohort study using prospectively collected healthcare data from the Skåne region, Sweden (~1.4 million residents). We extracted diagnoses for OA and 67 common chronic conditions. We included individuals aged 40+ years on 31 December 2007, with inc

Background and purpose — Different marker-selection methods are applied to represent implant and tibial seg-ments in radiostereometric analysis (RSA) studies of total knee arthroplasty (TKA). Either a consistent set of markers throughout subsequent RSA examinations (“consistent-marker method”) is used or all available markers at each follow-up (“all-marker method”). The aim of this secondary analy

Objective To compare experiences of the second stage of labour in women randomised to assistance by one or by two midwives to reduce severe perineal trauma (SPT). Design Analysis of a secondary outcome within the Swedish Oneplus multicentre randomised trial. Setting Five obstetric units in Sweden between December 2018 and March 2020. Participants Inclusion criteria in the Oneplus trial were women