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Glucokinase plays an important role in the regulation of insulin secretion and is therefore an attractive candidate gene for both insulin dependent (IDDM) and non-insulin-dependent (NIDDM) diabetes mellitus. A single G-A nucleotide polymorphism at the -30 position of the beta-cell specific promoter region of the glucokinase gene was previously associated with reduced beta-cell function. In the pre
An increased use of wood can reduce the environmental footprint of the building sector by being a renewable and ecological material. In order to improve the competitiveness of heavy timber structures, this thesis presents a novel type of timber connection with a high degree of prefabrication, which utilizes a resilient bond line.It has previously been shown that a large conventional stiff adhesive
This study aimed to investigate the influence of stroke lesions in predefined highly interconnected (rich-club) brain regions on functional outcome post-stroke, determine their spatial specificity and explore the effects of biological sex on their relevance. We analyzed MRI data recorded at index stroke and ~3-months modified Rankin Scale (mRS) data from patients with acute ischemic stroke enrolle
Johan Malm är forskargruppsledare för den här forskargruppenOur research consists of several branches: 1) Blood coagulation. We perform basic research within the field of blood coagulation, thrombosis, arteriosclerosis and the complement system. Focus is on understanding fundamental mechanisms of the coagulation process which could be used in diagnostics or therapies. 2) Prostate cancer and noninvasive diagnostics. The objective is to satisfy the need for
The overall goal of our research unit is to understand metabolic control of insulin secretion and why it fails in type 2 diabetes (T2D). In recent years, this has meant that we have used information from GWAS (Genome-wide association study) to direct our efforts towards the genes which are actually linked to the development of the disease. To reach this overarching goal, we have worked along tw
In spite of frequent discussions of misuse and misunderstanding of probability values (P-values) they still appear in most scientific publications, and the disadvantages of erroneous and simplistic P-value interpretations grow with the number of scientific publications. Osteoarthritis and Cartilage prefer confidence intervals. This is a brief discussion of problems surrounding P-values and confide
The monoclonal antibody 10E4, which recognizes an epitope supposed to contain N-unsubstituted glucosamine, is commonly used to trace heparan sulfate proteoglycans. It has not been fully clarified if the N-unsubstituted glucosamine is required for antibody recognition and if all heparan sulfates carry this epitope. Here we show that the epitope can contain N-unsubstituted glucosamine and that nitri
Attention deficit hyperactivity disorder (ADHD) is the most prevalent neuropsychiatric disorder in the world. Currently, the diagnosis is based mainly on interviews, resulting in uncertainties in the clinical assessment. While some neuropsychological tests are used, their specificity and selectivity are low, and more reliable biomarkers are desirable. Previous research indicates that ADHD is assoc
This paper examines the source of price discovery for Islamic stocks. We pair a large number of Islamic stocks to country-specific index futures and estimate price discovery using a vector error correction model. The results obtained using data for 19 countries suggest that for most countries (63% of the sample) price discovery is dominated by the spot market. We show that for these countries, a m
