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Cyclic nucleotide phosphodiesterases (PDEs) are important regulators of signal transduction processes mediated by cAMP and cGMP. One PDE family member, PDE3B, plays an important role in the regulation of a variety of metabolic processes such as lipolysis and insulin secretion. In this study, the cellular localization and the role of PDE3B in the regulation of triglyceride, cholesterol and glucose
A key to successful chronic neural interfacing is to achieve minimal glial scarring surrounding the implants, as the astrocytes and microglia may functionally insulate the interface. A possible explanation for the development of these reactions is mechanical forces arising between the implants and the brain. Here, we show that the difference between the density of neural probes and that of the tis
The electrical output of low concentration systems with standard pv cells is heavily impaired by non uniform irradiation distribution on the cells. In order to design new concentrators that improve the system efficiency by homogenizing the light, a new method of evaluation has been developed. It is based on simulations, and generates an estimated annual output. The method consists of three steps,
This paper attempts to assemble a conceptual framework for understanding to what extent an energy technology is simply a way of putting nature to work, and to what extent it is a way of putting other segments of global society to work. The turn to fossil energy reversed the relation between energy and space, as fossil fuels henceforth propelled new transport technologies that provided access to in
Voltage-gated Ca2+ (CaV) channels trigger glucose-induced insulin secretion in pancreatic beta-cell and their dysfunction increases diabetes risk. These heteromeric complexes include the main subunit alpha1, and the accessory ones, including subunit gamma that remains unexplored. Here, we demonstrate that CaV gamma subunit 4 (CaVγ4) is downregulated in islets from human donors with diabetes, diabe
This paper examines policy processes surrounding the rise and fall of the proposed EU-wide policy instrument designed to help achieve EU´s renewable energy targets – the trading of Guarantees of Origin (GO). It discusses its origins and examines factors in the policy processes over time leading first to its development and then to its rejection. A first analysis looks at the near-term policy-makin
Reflecting the multiple ambiguities of its ordinary language use, the current scholarly use of the term(s) “medium”/“media” is fraught with contradictions. Starting out from the insight that the nucleus of any kind of communication is an act, in which an addresser presents an artefact and a task of interpretation to an addressee, which the latter is called upon to fulfil, anything else that accrue
The purpose of this thesis is to explore how marketing freelancers perceive personal branding and how they practice it. Both offline and online environments for practicing personal branding have been included. The aimed contribution is to broaden the understanding of personal branding by adding the perceptions that marketing freelancers have towards this topic. Additionally, the attempt is to prov
The last 20 years efforts to find a long-term and large-scale biofuel alternative to petrol and diesel for the transport sector have been intensified with a focus on liquid biofuels, such as ethanol, methanol and Fischer-Tropsh diesel derived from wood. The large-scale production of biomethane has so far largely been overlooked in comparative studies that focus on the long-term renewable options.
Increased adoption of PV systems can help to mitigate climate change as it increases the use of renewable energy instead of fossil fuels and thus decreases greenhouse gas emissions.
The main options for deep decarbonisation of primary steel production are to continue using coal and employ carbon capture and storage (CCS) or to change the production process to direct reduction by utilizing hydrogen produced from renewable energy resources. In India, the world's second-largest steel producer, a shift to renewables is inhibited by the current power market regime, which includes
The empirical part of this study is based on a survey of 600 Swedish households and a number of interviews where questions about residential energy behaviour and possible policy instruments for change were raised. The study provides insight into current behavioural patterns and gives a bottom-up perspective on the realistic perspective potentials for change and ways to achieve them. Residential en
