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RhoH is a small GTPase expressed only in the hematopoietic system. With the use of mice with targeted disruption of the RhoH gene, we demonstrated that RhoH is crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Furthermore, the differentiation and expansion of DN3 and DN4 thymocytes in vitro were severely impaired. These defects corresponded to defective T
Age-related decline in cardiac function can be prevented or postponed by lifelong endurance training. However, effects of normal ageing as well as of lifelong endurance exercise on longitudinal and radial contribution to stroke volume are unknown. The aim of this study was to determine resting longitudinal and radial pumping in elderly athletes, sedentary elderly and young sedentary subjects. Furt
Background Transcriptional regulation of the genes in metabolic pathways is a highly successful strategy, which is virtually universal in microorganisms. The lac operon of E. coli is but one example of how enzyme and transporter production can be made conditional on the presence of a nutrient to catabolize. Methodology With a minimalist model of metabolism, cell growth and transcriptional regula
Research Purpose: This study aims to provide insight into the consumer perceptions of explicit marketing towards LGBT consumers. Furthermore, it examines the current status of implicit gay marketing Methodology: Triangulation was adopted combining both content analysis and netnography to qualitatively analyse consumer perceptions from three different perspectives. Content analysis was conducted fr
Fossil fuel subsidies continue to be a considerable barrier to meeting the targets of the Paris Agreement. It is thus crucial to understand the political economy of fossil fuel subsidies and their reform. To understand these mechanisms in the developed world, we use a database of different types of fossil fuel subsidy reforms among Organisation for Economic Co-operation and Development (OECD) coun
AimThe aim was to explore the ambulance service as experienced by present and former employees.BackgroundOver the last decade, the number of ambulance assignments has increased annually by about 10%, and as many as 50% of all ambulance assignments are considered non-urgent. This raises questions about which assignments the Ambulance Service (AS) is supposed to deal with.Design/methodData were coll
Full-scale ethanol production from spruce has been evaluated, mainly from an energy perspective, using an Aspen Plus-model including all major process steps. The model input was based on data recently obtained on lab scale or in a process development unit. A number of different process configurations are presented in order to demonstrate how heat integration within the ethanol process significantl
Desalination can be a cost-effective way to produce fresh water and possibly electricity. The Gaza Strip has had a complex hydro-political situation for many years. Gaza (enclosed area) is bordered by the Mediterranean in the west, by Israel in the north and east and by Egypt in the south. Water and electricity consumption in the Gaza Strip is expected to increase in the future due to the increasi
Over the past decade, organic–inorganic hybrid perovskites have revolutionized next-generation semiconductors, driving unprecedented advancements in cost-effective optoelectronics. While lead-based perovskite semiconductors exhibit exceptional optoelectronic properties, their inherent toxicity and vulnerability to environmental degradation remain significant barriers to widespread commerciali
Hudcancer, inklusive malignt melanom, keratinocytcancer (tidigare icke-melanomhudcancer) och också mer sällsynta hudcancerdiagnoser ökar snabbt i de flesta ljushyade populationer. En hudcancerdiagnos ger inte bara inverkan på hälsoekonomiska mätvärden utan också främst på individens livskvalitet. I vår forskargrupp fokuserar vi på kliniskt baserad och registerbaserad hudcancerforskning men även tiSkin cancers, including malignant melanoma, keratinocyte cancer (formerly non- melanoma skin cancer) and also more rare skin cancers are increasing rapidly in most fair-skinned populations. A skin cancer diagnosis has impact not only on health economics but also on the quality of life of the individual. In our research group we focus on clinical skin cancer research as well as on translational ski
Hållbarhet och beredskap är tätt sammankopplade när det gäller livsmedelsproduktion. Sveriges livsmedelssystem är sårbart: mycket av maten produceras utomlands och en stor del av vår livsmedelsproduktion är beroende av foder och gödsel som transporteras hit via långa logistikkedjor. Livsmedelssystemet är byggt för kostnadseffektivitet runt några få centrala noder, med minimal lagerhållning och kor
Amassing the available solar energy over the Sahara desert, through the installation of a large-scale solar farm, would satisfy the world’s current electricity needs. However, such land use changes may affect the global carbon cycle, possibly offsetting mitigation efforts. Here a fully coupled Earth System model EC-Earth was used to investigate the impact of a Saharan solar farm on the terrestrial
A new influenza virus that was first detected in people in April 2009, was initially referred to colloquially as "swine flu", since it contained genes from swine, avian and human influenza viruses. It can, however, not be transmitted by eating pork or dealing with pigs. In Egypt, several hundred thousand pigs were killed in May, in spite of advice from global health authorities that such an action
