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Targeting the androgen receptor (AR) pathway prolongs survival in patients with prostate cancer, but resistance rapidly develops. Understanding this resistance is confounded by a lack of noninvasive means to assess AR activity in vivo. We report intracellular accumulation of a secreted antigen-targeted antibody (SATA) that can be used to characterize disease, guide therapy, and monitor response. A
This paper explores the potential of corpus data to account for language users’ mental representations of a high-frequency item that is prone to phonetic reduction. We present an analysis of the realisations of semi-modal have to in spoken American English, which is a candidate for to-contraction (compare wanna and gotta) but has no clearly established contracted form. The study therefore focusses
Background: Implementing the evidence-based Individual Placement and Support (IPS) model in welfare states like Sweden faces contextual challenges that often necessitate local adaptations to enhance fit and effectiveness. While fidelity assessments aim to ensure effective outcomes, adaptations may lead to unintended drift from core components. The Model for Adaptation Design and Impact (MADI) helpBackground: Implementing the evidence-based Individual Placement and Support (IPS) model in welfare states like Sweden faces contextual challenges that often necessitate local adaptations to enhance fit and effectiveness. While fidelity assessments aim to ensure effective outcomes, adaptations may lead to unintended drift from core components. The Model for Adaptation Design and Impact (MADI) help
BACKGROUND: Effector functions of IgG antibodies (Abs) are regulated by their Fc N-glycosylation pattern. IgG Fc glycans that lack galactose and terminal sialic acid residues correlate with the severity of inflammatory (auto)immune disorders and have also been linked to the protection against viral infection and discussed in the context of vaccine-induced protection. In contrast, sialylated IgG Ab
The interaction between living groups A, C and G streptococci and IgG Fc was studied using human IgG, IgG Fc and IgG Fc-intermediate (Fci) fragments, chemically modified human IgG and fragment D of staphylococcal protein A (SPA). Diethylpyrocarbonate modification of His or N-acetylimidazole modification of Tyr of human IgG resulted in the loss of its capacity to inhibit the binding of radiolabelle
The major histocompatibility complex (MHC) is central in adaptive immunity, with the highly polymorphic MHC genes encoding antigen-presenting molecules. Two MHC class II (MHC-II) loci, DA1 and DA2, predate the radiation of extant birds and persist throughout much of the avian phylogeny. Within each locus, the MHC-II molecules are encoded by A-genes (DAA) and B-genes (DAB), which are arranged in A–
This dissertation is about the view of writing. One of the intentions of the study is to analyse different notions of writing that become manifest in media debates about student writing. Another intention is to analyse conceptions of writing in curricula and course plans for upper secondary school in Sweden from 1970 to 2011. Drawing from theories of critical discourse analysis, the study aimThis dissertation is about the view of writing. One of the intentions of the study is to analyse different notions of writing that become manifest in media debates about student writing. Another intention is to analyse conceptions of writing in curricula and course plans for upper secondary school in Sweden from 1970 to 2011. Drawing from theories of critical discourse analysis, the study aim
The Maputo Declaration was launched in 2003 as a response to the stagnation of African agriculture. The signatories agreed that 10% of public expenditure should be spent on agriculture in an effort to increase agricultural productivity. This paper examines to what degree the goal of the Maputo declaration has been reached. Little to no evidence was found for a direct positive impact on agricultura
Rapid urbanisation coupled with unplanned development create the perfect recipe for a disaster, the risk of which has increased with climate change-related uncertainties. Belgrade’s high population growth rate and exposure to riverine flooding presents such a case. This study aims to provide insight into the relationship between urban development and riverine flooding in Belgrade and thereby induc
Background: The development of factor (F) VIII neutralizing alloantibodies (inhibitors) is a major complication of treatment with FVIII concentrates in hemophilia A and the etiology is still poorly understood. The low-affinity Fc gamma receptors (Fc gamma R), which are expressed on immune cells, provide an important link between cellular and humoral immunity by interacting with IgG subtypes. Genet
The London congestion charging scheme has been in place since the 17th of February 2003 and there is little doubt that, so far, the objectives set out prior to the introduction of the charge have been achieved. The purpose of this paper is to examine the effect the congestion charge have had on the air quality in central London. This was done by studying daily data on a number of pollutants that c
Aim: Grass-yellow butterflies (Eurema) are a group of pantropical Pieridae distributed throughout Asia, Australasia, Africa and the New World. However, little is known about their diversification, including the biogeographic mechanism(s) explaining their circumglobal distribution. We present the first densely sampled, time-calibrated phylogeny and biogeographic reconstruction of grass-yellows to c
Before the introduction of the euro in 1999, the CFA Franc was pegged towards the French national currency the Franc at a fixed parity. When France adopted the European single currency as its legal tender, the currency arrangement of 14 African counties changed as well. This paper examines whether the euro has had any significant effect on trade between the CFA franc zone and the Eurozone countrie
https://www.historiskamuseet.lu.se/english - 2026-07-01
Twenty-six patients were operated because of osteo-arthritis of the trapeziometacarpal joint. After excision of the trapezium, they were randomized to receive either a Swanson silicone trapezium implant or a tendon interposition arthroplasty using a strip of the abductor pollicis longus tendon (APL). No infection or clinical silicone synovitis occurred and no major radiographic cyst formation was
