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Alveolar Progenitor Cells in Lung Damage and Regeneration

A Ph.D. Interview with Victoria Ptasinski Victoria Ptasinski, a Ph.D. student at Lund University, defended her thesis on November 27, 2023. Her academic journey has been driven by a burning interest to understand what she considers to be the biggest mystery in this world, the human lung, particularly concerning diseases such as idiopathic pulmonary fibrosis (IPF). Through a close collaboration wit

https://www.stemcellcenter.lu.se/phd-interview-victoria-ptasinski - 2026-05-15

Poor inter-observer agreement in anatomical classifications of infrapopliteal arterial disease due to mandatory selection of only one target artery

BACKGROUND: Established anatomical classifications of infrapopliteal arterial lesion severity are based on assessment of only one target artery, not including all infrapopliteal arteries although multivessel revascularization is common.PURPOSE: To investigate the reproducibility of one of these classifications and a new aggregated score.MATERIAL AND METHODS: A total of 68 patients undergoing endov

Imagine a world without cancer

BACKGROUND: Since the "War on Cancer" was declared in 1971, the United States alone has expended some $300 billion on research, with a heavy focus on the role of genomics in anticancer therapy. Voluminous data have been collected and analyzed. However, in hindsight, any achievements made have not been realized in clinical practice in terms of overall survival or quality of life extended. This migh

Prevalence and Determinants of the Composite Index of Anthropometric Failure in Children Under Five Years in Bangladesh: Insights From a National Survey

ABSTRACT Child undernutrition remains a significant public health issue in Bangladesh, with high rates of stunting, wasting, and underweight. The Composite Index of Anthropometric Failure (CIAF) offers a comprehensive tool for assessing overall undernutrition. Although previous studies in Bangladesh have utilized CIAF, they have relied on older datasets. Estimating the current status is essential

Stakeholders' Perspectives on the Landscape of Peer Support in Swedish Mental Health Services : A Qualitative Study

The integration of peer support workers (PSW) into the mental health services workforce has offered additional avenues to strengthen service provision. In Sweden, the availability of peer support workers has grown significantly over the past decade, yet there has been insufficient investigation into their organization and implementation. Consequently, there is a growing need for further research i

Low convergent validity of [11C]raclopride binding in extrastriatal brain regions : A PET study of within-subject correlations with [11C]FLB 457

Dopamine D2 receptors (D2-R) in extrastriatal brain regions are of high interest for research in a wide range of psychiatric and neurologic disorders. Pharmacological competition studies and test-retest experiments have shown high validity and reliability of the positron emission tomography (PET) radioligand [11C]FLB 457 for D2-R quantification in extrastriatal brain regions. However, this radioli

PD fluids contain high concentrations of cytotoxic GDPs directly after sterilization

Objective: Glucose degradation products (GDPs) in peritoneal dialysis (PD) fluids are cytotoxic and affect the survival of the peritoneal membrane. One of the most reactive GDPs in PD fluids is 3,4-dideoxyglucosone-3-ene (3,4-DGE). 3,4-DGE has been reported as an intermediate between 3-deoxyglucosone (3-DG) and 5-hydroxymethyl furaldehyde (5-HMF) during degradation of glucose. In PD fluids, 3,4-DG

Effect of cereal test breakfasts differing in glycemic index and content of indigestible carbohydrates on daylong glucose tolerance in healthy subjects

BACKGROUND: Frequent hyperglycemic episodes are increasingly being associated with an increased risk of type 2 diabetes and cardiovascular disease. OBJECTIVE: We studied the extent to which acute glycemia and glycemia after subsequent meals can be modulated by the characteristics of cereal foods, such as glycemic index (GI) and content of indigestible carbohydrates. DESIGN: Twelve healthy subjects

External and internal irradiation of a Rural Bryansk (Russia) population from 1990 to 2000, following high deposition of radioactive caesium from the chernobyl accident.

In 1990, a joint Nordic-Russian project was initiated in order to make independent estimations of the effective dose to selected groups of inhabitants in a highly contaminated area around the city of Novozybkov In the western Bryansk region of Russia. The inhabitants were living in six villages with initial contamination levels of Cs-137 between 0.9 and 2.7 MBq m(-2). Some villages had been decont

Differential effects of LPS from Escherichia coli and Porphyromonas gingivalis on IL-6 production in human periodontal ligament cells.

Abstract Objective. Periodontal ligament (PDL) cells produce IL-6 upon stimulation with inflammation promoters, but the signaling pathways involved have not been characterized. This study investigates underlying mechanisms behind regulation of PDL cell IL-6 production by E. coli and P. gingivalis LPS. Materials and methods: Human PDL cells, endothelial cells and monocytes were stimulated with E. c

Endoscopic sphincterotomy for bile duct calculi: factors influencing the success rate. Hepato-Gastroenterol 1996; 43: 127-133.

BACKGROUND/AIMS: Endoscopic sphincterotomy is an established treatment of retained or recurrent common bile duct calculi after cholecystectomy and in the majority of patients with an intact gallbladder. In order to identify patients ultimately requiring additional endoscopic procedures or surgery, factors predictive of decreased endoscopic bile duct clearance were sought. MATERIAL AND METHODS: Bet

A study of Tamm-Horsfall protein excretion in hypertensive patients and type 1 diabetic patients

OBJECTIVE: The study was performed in order to evaluate to what extent hypertension or diabetes mellitus may affect the urinary excretion rate of Tamm-Horsfall protein. MATERIALS AND METHOD: The urinary excretion rates of albumin and Tamm-Horsfall protein, a measure of glomerular and distal tubular function, respectively were measured in patients with essential hypertension (n = 17) and in type 1

Potent inhibitors of uropathogenic E. coli papG adhesins; Synthesis, conformational studies and biological evaluation of galabiose derivatives and synthesis of glycosphingolipid analogues

The importance of carbohydrates in biological systems has become evident during the last fifty years. It is well known that pathogenic bacteria and viruses attach to glycoconjugates present at mammalian cell surfaces, and that this attachment is a prerequisite for the later stages of infection. Obviously, this interaction is interesting as a target for the development of novel ways to treat bacter

Initial clinical experience with a new biointegrative cement for vertebroplasty in osteoporotic vertebral fractures.

Summary: Polymethylmethacrylate, as a widely used material for vertebroplasty, has several drawbacks such as heat development and high allergenic potential. In order to avoid these drawbacks ceramic cement materials have been developed. The purpose of this study was to evaluate a new biointegrative material for vertebroplasty in osteoporotic vertebral fractures regarding pain relief, safety aspect

Retinal Vein Occlusion A clinical study of electrophysiology, certain prognostic factors and treatment.

Popular Abstract in Swedish Påverkan av faktor V Leiden-mutationen på risk för utveckling av neovaskulära komplikationer efter centralvenstrombos studerades. Hos patienter med mutationen var risken nästan tre gånger högre att utveckla neovaskulära komplikationer än hos patienter utan mutationen. Synnervssvullnad , som nyligen har presenterats som en indikator på god prognos vid centralvenstrombosThe influence of the factor V Leiden mutation on the development of neovascular complications in central retinal vein occlusion was studied. The presence of the mutation was found to enhance the risk of developing neovascular complications almost threefold compared to in patients without the mutation. Optic nerve head swelling, which recently has been presented as an indicator of good prognosis i

Multi-Sided Platforms: Understand their strengths and weaknesses

Title: Multi-Sided Platforms: Understanding their strengths and weaknesses Seminar date: 2014-05-22 Course: FEKN90 Företagsekonomi: Examensarbete på Civilekonomprogrammet (30 ECTS) Authors: Lucas Ehrenstråhle and Elin Mathies Supervisor: Magnus Johansson Five keywords: MSP, activities, resources, differentiation and platforms The purpose: is to investigate why small actors use multi-sided pl

Real-time imaging of cerebrospinal fluid flow physiology at 7T

Ryggmärgsvätskan, eller cerebrospinalvätskan, är en klar, plasmaliknande vätska som fyller ventriklarna (hålrum i hjärnan) och rummen innanför kraniet och ryggraden. Ryggmärgsvätskan hjälper till att upprätthålla immunförsvaret och balansen av viktiga ämnen. Det agerar även som transportsystem för slaggprodukter ut ur det centrala nervsystemet för lösa ämnen som inte kan passera genom blod-hjärnbaBackground The cerebrospinal fluid (CSF) is involved in several diseases and patho- physiological states, such as Alzheimer’s disease and hydrocephalus. Previous studies CSF dynamics in the brain show that the flow of the CSF depends on cardiac pulsation, time of day and respiration. Methods In this thesis, the validity of using real time phase contrast MRI in order to study CSF flow is evaluated