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Molecular and Structural Biomarkers of Inflammation at Two Years After Acute Anterior Cruciate Ligament Injury Do Not Predict Structural Knee Osteoarthritis at Five Years

Objective: To determine the role of inflammatory biomarkers at 2 years post–anterior cruciate ligament (ACL) injury to predict radiographic knee osteoarthritis (OA) and magnetic resonance imaging (MRI)–defined knee OA at 5 years postinjury, with a secondary aim of estimating the concordance of inflammatory biomarkers assessed by MRI and synovial fluid (SF) analysis. Methods: We studied 113 patient

Cardiometabolic Polygenic Risk Scores and Osteoarthritis Outcomes : A Mendelian Randomization Study Using Data From the Malmö Diet and Cancer Study and the UK Biobank

Objective: To investigate the causal role of cardiometabolic risk factors in osteoarthritis (OA) using associated genetic variants. Methods: We studied 27,691 adults from the Malmö Diet and Cancer Study (MDCS) and replicated novel findings among 376,435 adults from the UK Biobank. Trait-specific polygenic risk scores for low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol

Towards classification criteria for early-stage knee osteoarthritis : A population-based study to enrich for progressors

Objective: To facilitate a greater likelihood of favorable response to new disease-modifying therapies, recruitment of patients at an earlier stage of their disease into clinical trials may be an attractive strategy. Hence, there is a need to develop widely accepted classification criteria for early-stage knee osteoarthritis (OA). We have proposed a set of classification criteria for early-stage k

Characterization of male breast cancer : Results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program

Background: Male breast cancer (BC) is rare, managed by extrapolation from female BC. The International Male BC Program aims to better characterize and manage this disease. We report the results of part I, a retrospective joint analysis of cases diagnosed during a 20-year period. Methods: Patients with follow-up and tumor samples, treated between 1990 and 2010, in 93 centers/9 countries. Samples w

Protein S100 as outcome predictor after out-of-hospital cardiac arrest and targeted temperature management at 33 °C and 36 °C

Background: We aimed to investigate the diagnostic performance of S100 as an outcome predictor after out-of-hospital cardiac arrest (OHCA) and the potential influence of two target temperatures (33 °C and 36 °C) on serum levels of S100. Methods: This is a substudy of the Target Temperature Management after Out-of-Hospital Cardiac Arrest (TTM) trial. Serum levels of S100 were measured a posteriori

Clinical aspects of molecular profiles in metastatic malignant melanoma

Malignant melanoma is a heterogeneous, malignant neoplastic disease, most often originating in the skin. Melanoma is characterized by a high mutational load and has a vastly variable prognosis, depending on disease stage. Genetic aberrations in the mitogen-activating protein kinase (MAPK) pathway are important in melanoma, of which mutations in BRAF and NRAS are the most common. Additionally, recu

Racial and Ethnic Differences in the Association Between Classical Cardiovascular Risk Factors and Common Carotid Intima-Media Thickness : An Individual Participant Data Meta-Analysis

BACKGROUND: The major risk factors for atherosclerotic cardiovascular disease differ by race or ethnicity but have largely been defined using populations of European ancestry. Despite the rising prevalence of cardiovascular disease in Africa there are few related data from African populations. Therefore, we compared the association of established cardiovascular risk factors with carotid-intima med

Monte Carlo Simulations of a Clinical PET system using the GATE Software

Monte Carlo-simuleringar har fått en ökad betydelse som forskningsverktyg inom nuklearmedicinsk bildgivning eftersom man på ett mycket kontrollerat sätt kan studera nästan vad man vill. I denna studie har datorsimuleringar av ett PET-system gjorts med ett program som heter GATE. PET (Positron Emission Tomography) är en nuklearmedicinsk bildgivningsteknik som används mer och mer inom sjukvården sIntroduction: Monte Carlo simulation is a powerful tool in research in the field of nuclear medicine imaging and there is a wide area of applications. The purpose of this work was (1) to understand the basics of the Monte Carlo simulation software Geant4 Application for Tomographic Emission (GATE); (2) to create a model of Philips Gemini TF PET/CT system; (3) to run a number of simulations to comp

Analysis of vibrations in high-tech facility

MAX-lab is a national synchrotron radiation facility in Lund. Nowadays, the MAX project consist of three facilities (three storage rings). A new storage ring is needed to improve material science, such as nanotechnology. MAX IV, also in Lund, will be 100 times more efficient than already existing synchrotron radiation facilities. The storage ring is controlled by a large number of magnets that are

Early Ezetimibe Initiation After Myocardial Infarction Protects Against Later Cardiovascular Outcomes in the SWEDEHEART Registry

Background: Combination lipid-lowering therapy (LLT) after myocardial infarction (MI) achieves lower low-density lipoprotein cholesterol (LDL-C) levels and better cardiovascular outcomes vs statin monotherapy. As a result, global guidelines recommend lower LDL-C but, paradoxically, advise treatment through a stepwise approach. Yet the need for combination therapy is inevitable as <20% of patients

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Licentiate Dissertation Structural Mechanics PETER PERSSON REDUCTION IN GROUND VIBRATIONS BY THE USE OF WAVE OBSTACLES Denna sida skall vara tom! DEPARTMENT OF CONSTRUCTION SCIENCES DIVISION OF STRUCTURAL MECHANICS ISRN LUTVDG/TVSM--13/3072--SE (1-102) | ISSN 0281-6679 LICENTIATE DISSERTATION Copyright © 2013 Division of Structural Mechanics Faculty of Engineering (LTH), Lund University, Sweden. P

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm3000/web3072.pdf - 2026-05-24

Improving Climate Resilience and Thermal Comfort in a Complex Building through Enhanced Flexibility of the Energy System

This research evaluates the impacts of flexible demand-side management on electricity load and indoor thermal comfort under extreme weather conditions, focusing on elderly people. For this purpose, an elderly care center in Alesund, Norway is chosen as the pilot building. A high spatiotemporal resolution building energy model is developed including thermal zones and energy systems, verified agains

Advancing a tourist perspective in inclusive place branding: : anticipated constraints of domestic tourists with foreign backgrounds

Research on inclusive place branding has primarily focused on residents, while tourists are yet to be addressed, except in representation studies. Inclusion is, however, more than a matter of representation. It must also consider the needs of the tourists. This study explores people with foreign backgrounds' anticipated constraints to domestic tourism. This article advances knowledge of inclusive

Frånvarande kvinnliga subjekt - en analys av medicinska texter om klimakteriet

The article "Missing female subjects. An analysis of medical texts about menopause" focuses on medical discourses about women and middle age. More concretely, it presents an analysis of articles in Läkartidningen from 1990 through 2001. Läkartidningen is the official journal of the Swedish Medical Association and has a distribution of nearly 30 000 copies. The analysis is based upon three qualitat

Introducing patient-reported outcome in the acute leukemia quality registries in Sweden

Objectives: The use of patient-reported outcome (PRO) measured outside clinical trials is not well defined. We report the first analysis of the prospective PRO study within the Swedish acute myeloid leukemia (AML) and the acute lymphoblastic leukemia (ALL) registries. Methods: PRO was requested 6 months after diagnosis. The EORTC Quality of life Questionnaire Core 30-item, the Patient Health Quest

A Study of Human Perception of Intonation in Domestic Cat Meows

This study examined human listeners’ ability to classify domestic cat vocalisations (meows) recorded in two different contexts; during feeding time (food related meows) and while waiting to visit a veterinarian (vet related meows). A pitch analysis showed a tendency for food related meows to have rising F0 contours, while vet related meows tended to have more falling F0 contours. 30 listeners judg

Interesting, funny, weird or just incomprehensible? A study on Swedish Japanese learning students’ comprehension, thoughts and attitudes towards Wasei-eigo

This thesis investigates to what extent Swedish students of Japanese can understand wasei-eigo, as well as their thoughts and attitudes toward it. It further investigates if some word categories are more incomprehensible than others and what aspects can determine their comprehension. The survey consisted of a questionnaire with 30 words, divided into 4 different categories, which the participants

Nya Södergård

År 2016 flyttade min syster och hennes familj till en gård vid namn Södergård med tillhörande 30 hektar mark på landsbygden utanför småländska Älmhult. Gårdens byggnader är klassiskt faluröda med vita knutar och ligger i ett idylliskt landskap där mörk skog möter öppen betesmark. Familjens livssituation på gården har ändrats och idag är de i behov av en bostad med andra krav än Södergård kan erbjuIn 2016, my sister and her family moved to a farm called Södergård with 30 hectares of land in the countryside outside Småland's Älmhult. The farm's buildings are classically Faluröda with white corners and are located in an idyllic landscape where dark forest meets open pasture land. The family's life situation on the farm has changed and today they are in need of a home with other re

Vuxna fosterbarn: hur påverkar barndomen deras vuxenliv

The purpose was to investigate "adult foster childrens" view on their childhood and how it may have been influencing their adulthood. The importance of relationships were mostly in focus in the essay. The method was qualitative deepinterviews with three adult foster children between 30-42 years of age. Important themequestions was about: origin family, the time in foster home, relations