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30th Nordic Medical History Congress (in Gothenburg)

21 april 2027 09:00 till 23 april 2027 16:00 | Konferens The Nordic Congress on the History of Medicine will take place in Gothenburg in April 2027 for its 30th meeting. Main Theme: Water in Health and Disease. The Nordic Congress on the History of Medicine, first convened in Gothenburg in 1967, will return to Gothenburg in April 2027 for its 30th meeting.Time: Wednesday April 21 - Friday April 23

https://www.medicinhistoria.lu.se/evenemang/30th-nordic-medical-history-congress-gothenburg - 2026-04-29

Treatment Preferences for Acute Allergic Reactions : A Discrete Choice Experiment

Background: Timely treatment of acute allergic reactions (AARs) is important to minimize reaction severity. Corticosteroid tablets dissolved in water are commonly used in mainstay treatment. A new oral film that dissolves on the tongue provides a faster and less cumbersome alternative to tablets for corticosteroid administration during AARs. This study evaluated patients' preferences for attribute

Frequent finding of the androgen receptor A645D variant in normal population.

Background: The androgen receptor A645D mutation has been described in one patient with ambiguous genitalia and one boy with normal phenotype. Objective: Because of this phenotypic variation, we screened a cohort of men from the general population (n = 293) as well as men with the following disorders of the genital tract for the mutation: men with prostate cancer (n = 89), testicular cancer (n = 8

A comparison of the effects of carvedilol and metoprolol on well-being, morbidity, and mortality (the "patient journey") in patients with heart failure - A report from the Carvedilol or Metoprolol European Trial (COMET)

OBJECTIVES This study was designed to investigate the loss of well-being, in terms of lift-years, overall and in patients randomized to metoprolol versus carvedilol in the Carvcdilol Or Metoprolol European Trial (COMET). BACKGROUND The ultimate objectives of treating patients with heart failure are to relieve suffering and prolong life. Although the effect of treatment on mortality is usually desc

Longitudinal movements and resulting shear strain of the arterial wall

There has been little interest in the longitudinal movement of the arterial wall. It has been assumed that this movement is negligible compared with the diameter change. Using a new high-resolution noninvasive ultrasonic method, we measured longitudinal movements and diameter change of the common carotid artery of 10 healthy humans. During the cardiac cycle, a distinct bidirectional longitudinal m

Prevention of oral mucositis with cryotherapy in children undergoing hematopoietic stem cell transplantations—a feasibility study and randomized controlled trial

Purpose: To evaluate the feasibility of oral cryotherapy (OC) in children and to investigate if OC reduces the incidence of severe oral mucositis (OM), oral pain, and opioid use in children undergoing hematopoietic stem cell transplantation (HSCT). Methods: Fifty-three children, 4–17 years old, scheduled for HSCT in Sweden were included and randomized to OC or control using a computer-generated li

Susceptibility to osteoporotic fracture is determined by allelic variation at the Sp1 site, rather than other polymorphic sites at the COL1A1 locus

Previous studies have identified an association between osteoporotic fracture and a polymorphism affecting a Sp1 binding site in the first intron of the collagen type I alpha 1 gene (COL1A1). It is currently unclear, however, whether this association is direct or the result of linkage disequilibrium with other polymorphisms situated nearby. In this study we analyzed the relationship between four w

Frequency of Achilles Tendon Xanthoma in Patients with Acute Coronary Syndrome

AIM: We studied the frequency of Achilles tendon xanthoma (ATX) in patients with acute coronary syndrome (ACS). Furthermore, we investigated the differences in clinical findings between ACS patients with and without ATX.METHODS: Patients with ACS (n=335) were admitted to the coronary care unit of Nippon Medical School between July 2011 and December 2014. Informed consent for the measurement of Ach

Maximally effective dosing regimens of meropenem in patients with septic shock

Objectives: To use a population pharmacokinetic approach to define maximally effective meropenem dosing recommendations for treatment of Acinetobacter baumannii and Pseudomonas aeruginosa infections in a large cohort of patients with septic shock. Methods: Adult patients with septic shock and conserved renal function, treated with meropenem, were eligible for inclusion. Seven blood samples were co

Prospective registration of symptoms and times to diagnosis in children and adolescents with central nervous system tumors : A study of the Swedish Childhood Cancer Registry

BACKGROUND: The elapsed time taken to diagnose tumors of the central nervous system in children and adolescents varies widely. The aim of the present study was to investigate such diagnostic time intervals at a national level in Sweden as they correlate with clinical features.METHODS: Data prospectively accumulated over a 4-year period in the Swedish Childhood Cancer Registry from patients aged 0-

Interobserver delineation variation in lung tumour stereotactic body radiotherapy

Objectives: In radiotherapy, delineation uncertainties are important as they contribute to systematic errors and can lead to geographical miss of the target. For margin computation, standard deviations (SDs) of all uncertainties must be included as SDs. The aim of this study was to quantify the interobserver delineation variation for stereotactic body radiotherapy (SBRT) of peripheral lung tumours

Quantification of human cytomegalovirus DNA by a new capture hybrid polymerase chain reaction enzyme-linked immunosorbent assay in plasma and peripheral blood mononuclear cells of bone marrow transplant recipients

OBJECTIVES: Quantitative monitoring of human cytomegalovirus infections is helpful in determining appropriate antiviral management in patients who receive bone marrow transplants. We sought to design and evaluate a new cytomegalovirus capture hybrid polymerase chain reaction enzyme-linked immunosorbent assay (PCR-ELISA) in plasma and peripheral blood mononuclear cells to monitor cytomegalovirus in

Proteomics and Phosphoproteomics of High-Grade Serous Ovarian Carcinoma Models Investigating Ferroptosis Induction and MTDH-SND1 Inhibition

High-grade serous ovarian carcinoma (HGSOC) is the most common subtype of ovarian cancer, often discovered in advanced stages and linked to poor survival. Due to high mortality rates, there is a need for novel treatment strategies. A promising new strategy is induction of ferroptosis, which has recently been shown to synergistically induce cell death in HGSOCs in combination with MTDH-SND1 protein

Signal and Background Studies at 8 GeV for the Light Dark Matter eXperiment

Light dark matter is a hypothesized form of dark matter in the 1 MeV to 1 GeV mass range. The Light Dark Matter eXperiment (LDMX) is an upcoming experiment to test the existence of light dark matter, by colliding an electron beam with a tungsten target and assembling a set of events that potentially indicate the existence of light dark matter. The three main detector components of the LDMX are a s

Recombinant FVIIa in elective non-orthopaedic surgery of adults with haemophilia and inhibitors : A systematic literature review

Aim: To assess available evidence on the use of rFVIIa in non-orthopaedic surgery including dental surgery in adult patients with congenital haemophilia with inhibitors (PWHI). Methods: A systematic literature search was performed according to a prespecified search string; prespecified criteria were used to select applicable studies including PWHI ≥18 years of age who underwent any non-orthopaedic