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Targeting the androgen receptor (AR) pathway prolongs survival in patients with prostate cancer, but resistance rapidly develops. Understanding this resistance is confounded by a lack of noninvasive means to assess AR activity in vivo. We report intracellular accumulation of a secreted antigen-targeted antibody (SATA) that can be used to characterize disease, guide therapy, and monitor response. A
In a previous study we presented data indicating that the expanded population of CD4(-)CD8(-) (DN) alphabeta T cells in TCRalpha-chain-transgenic mice was partially if not entirely derived from gammadelta T cell lineage cells. The development of both gammadelta T cells and DN alphabeta T cells is poorly understood; therefore, we thought it would be important to identify the immediate precursors of
In the early Holocene, Mesolithic hunter-gatherer communities inhabiting the Cis-Baikal region of Eastern Siberia were participating in a series of important cultural changes. These included the establishment of large cemeteries in the Angara Valley and on the Southwest shores of Lake Baikal, culminating in the formation of the distinctive Early Neolithic Kitoi cultural pattern ca. 7560 cal. BP. A
Det är ganska enkelt. Vi skickar post och paket till-, från- och inom universitetet. Vi fraktar stort och smått - i ental eller i tusental - och vi gör det snabbt, jättesnabbt eller i expressfart. Det är en lika enkel som viktig uppgift. Vi hoppas kunna göra din arbetsdag lite enklare.Our job is quite simple. We send mail and parcels to, from and within the University. We carry large and small items - singly or in thousands - and we do it fast, extremely fast or at express speed. Our task is as simple as it is essential. Our aim is to make your working day a little easier.
According to medieval canon law, mutual consent was sufficient to create a valid marriage. A marriage contracted secretly could thus be perfectly valid. Such marriages, i.e. clandestine marriages, did however constitute one of the major problems in the marriage legislation of the medieval Catholic Church. This problem was particularly apparent at the local level and practically all synodal statute
Group exhibition.'The horizon is always receding' brings together a selection of works that reflect on the scope and the implications that the term contemporary may have. As the philosopher Giorgio Agamben suggests, contemporaneity can be understood as a term that surpasses temporal demarcations and transcends simultaneity and coexistence. In this sense, this exhibition serves as a symptomatic dis
This article outlines an experimental and numerical study of moisture in concrete subjected to air, water or sealed curing. For this purpose columns of eight qualities of concrete were studied at 3 different ages each over a period of 450 days. Parallel studies of hydration, internal relative humidity, self-desiccation and strength were carried out. Finally the article presents an analysis of the
The tensions between tendencies to support and reject that can be observed in reception measures for newly-arrived students in Sweden are a consequence both of the general climate of hostility towards immigration in Europe, and features particular to Sweden. The paper summarises the historical background to the present situation, from the 1960s onwards, and points to some of the impacts for teache
A model is presented that describes the reemergence of parent spruce bark beetles, Ips typographus, based on breeding density and temperature conditions. Laboratory data obtained at one constant temperature provide the distribution of reemergence time and different combinations of threshold temperatures and degreedays (°D) at mean reemergence. Of these combinations, 167.71 °D above 7.5 °C gave the
