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PURPOSE: Gitelman's syndrome (GS) is an inherited autosomal recessive disorder due to loss of function mutations in the SLC12A3 gene encoding the Na-Cl co-transporter (NCCT), the target of thiazide diuretics. The defective function of the NCCT, which normally is expressed in the apical membrane of the distal convolute tubule in the kidney, leads to mild hypotension, hypokalemia, hyperreninemic hyp
Understanding how drugs work is of great importance, since it can facilitate drug discovery, both time- and costwise. At the same time, it is important to have methods that can help predict how well does a potential drug molecule bind to its target. Computational methods can in many ways contribute to drug design process. In this thesis, we employ different computational approaches to study the biUnderstanding how drugs work is of great importance, since it can facilitate drug discovery, both time- and costwise. At the same time, it is important to have methods that can help predict how well does a potential drug molecule bind to its target. Computational methods can in many ways contribute to drug design process. In this thesis, we employ different computational approaches to study the bi
The overarching objective of this study was to produce a disaggregated SMOS Soil Moisture (SM) product using land surface parameters from a geostationary satellite in a region covering a diverse range of ecosystem types. SEVIRI data at 15 min temporal resolution were used to derive the Temperature and Vegetation Dryness Index (TVDI) that served as SM proxy within the disaggregation process. West A
Nitrogen (N) cycle dynamics and N deposition play an important role in determining the terrestrial biosphere's carbon (C) balance. We assess global and biome-specific N deposition effects on C sequestration rates with the dynamic global vegetation model LPJ-GUESS. Modeled CN interactions are evaluated by comparing predictions of the C and CN version of the model with direct observations of C fluxe
Purpose: To determine the reproducibility of quantitative susceptibility mapping at multiple sites on clinical and preclinical scanners (1.5 T, 3 T, 7 T, and 9.4 T) from different vendors (Siemens, GE, Philips, and Bruker) for standardization of multicenter studies. Methods: Seven phantoms distributed from the core site, each containing 5 compartments with gadolinium solutions with fixed concentra
OBJECTIVE: A randomized controlled trial (RCT) was undertaken to determine the effect of negative pressure wound therapy (NPWT) on closed incisions after inguinal vascular surgery regarding surgical site infections (SSIs) and other wound complications. BACKGROUND: SSIs are a major concern in open vascular procedures involving the inguinal region. Prophylactic NPWT on closed incisions has shown pro
• • • • • • • KURSPLAN Omvårdnad, hälsa och livsvillkor hos äldre, 7,5 högskolepoäng Nursing Science, Elderly Persons Health and Living conditions, 7,5 credits Lärandemål Efter genomgången kurs ska studenten, inom områdena nedan, kunna: Kunskap och förståelse visa fördjupad förståelse för åldrandeprocessen utifrån ett livslopps-, individ- och samhällsperspektiv identifiera biologiska, psykologiska
https://www.student.med.lu.se/sites/student.med.lu.se/files/kursplan-omvardnad-halsa-livsvillkor-hos-aldre.pdf - 2026-06-12
Extern handledare och gästföreläsare i fri konst Kontaktinformation E-post: charif [dot] benhelima [at] khm [dot] lu [dot] seOrganisation Konsthögskolan i Malmö Charif Benhelima är en belgisk konstnär som bor och arbetar i Antwerpen. Benhelima närmar sig frågeställningar kring minne och glömska, tid och rum, ursprung, identitet, representationspolitik och varseblivning. Han fick sitt genombrott m
https://www.khm.lu.se/charif-benhelima - 2026-06-11
Socio-economic gradients are known to exist in cancer but we want to focus on the university-educated population and specifically on physicians to find out whether their special educational background on cancer causation helps them to avoid cancers. The analysis was based on the latest update of the Swedish Family-Cancer Database, in which the educational level was obtained from the national censu
Protein G, the immunoglobin G-binding surface protein of group C and G streptococci, also binds serum albumin. The albumin-binding site on protein G is distinct from the immunoglobulin G-binding site. By mild acid hydrolysis of the papain-liberated protein G fragment (35 kDa), a 28-kDa fragment was produced which retained full immunoglobulin G-binding activity (determined by Scatchard plotting) bu
Surface water is vital resources for terrestrial life, while the rapid development of urbanization results in diverse changes in sizes, amounts, and quality of surface water. To accurately extract surface water from remote sensing imagery is very important for water environment conservations and water resource management. In this study, a new Multi-Band Water Index (MBWI) for Landsat 8 Operational
The present study examines in a quantitative manner the relationship between the attitudes toward gender equality and those toward gender-inclusive language. It also studies how a text written with gender-inclusive language is evaluated and observes what factors can act thereupon. Firstly, statistical analyses show that women have more positive attitudes than men, and that residents in a French-sp
