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Streptococcus pyogenes is one of the most common bacteria infecting humans. One of the factors contributing to the disease-causing properties is the secreted streptococcal cysteine proteinase, SpeB, which degrades several host proteins in connective tissue and circulation. SpeB activity depends on the transformation from an inactive precursor, zymogen, into a mature proteinase. We show that

Background: Ocrelizumab is a humanized anti-CD20 antibody with increased antibody-dependent cellular cytotoxicity compared with rituximab. This phase I/II study evaluated its safety and efficacy in patients with relapsed/refractory follicular lymphoma (FL) after prior rituximab therapy. Design and methods: Forty-seven patients were treated in three dose cohorts and received eight infusions every 3

Streptococcus pyogenes (Group A streptococcus; GAS) is an important human pathogen responsible for mild to severe, life-threatening infections. GAS expresses a wide range of virulence factors, including the M family proteins. The M proteins allow the bacteria to evade parts of the human immune defenses by triggering the formation of a dense coat of plasma proteins surrounding the bacteria, includi

Primary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder associated with autosomal recessive variants in genes required for perforin-mediated lymphocyte cytotoxicity. A rapid diagnosis is crucial for successful treatment. Although defective cytotoxic T lymphocyte (CTL) function causes pathogenesis, quantification of natural killer (NK)–cell exocytosis triggered by K562 targe

Recent epidemiological data on diseases caused by beta-hemolytic streptococci belonging to Lancefield group C and G ( GCS, GGS) underline that they are an emerging threat to human health. Among various virulence factors expressed by GCS and GGS isolates from human infections, M and M-like proteins are considered important because of their anti-phagocytic activity. In addition, protein G has been i

INTRODUCTION: Synaptic dysfunction and loss are pathological hallmarks of neurodegenerative diseases. Neuronal pentraxin 2 (NPTX2), a presynaptic protein involved in synaptic plasticity, has been linked to cognitive decline in Alzheimer's disease (AD) and other neurodegenerative disorders. METHODS: We developed and validated a novel single molecule array (Simoa) for NPTX2 in cerebrospinal fluid, w

Preliminärt schema 171213 Miljöpolitik och förvaltning De tider där inget anges om rum gäller helklass i föreläsningssal Mossen Ö/V i Ekologihuset, Sölvegatan 37. Kursansvarig: Åsa Knaggård (ÅK) Övriga lärare: Tobias Nielsen (TN), Elias Isaksson (EI) och Maja Tejre (MT). Närvaro: Seminarier är i de flesta fall obligatoriska. Obligatoriska moment är markerade med fetstil i schemat. Om man ej kan de

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/mveb15_prel_schema_vt18.pdf - 2026-05-23

https://www.ehl.lu.se/sites/ehl.lu.se/files/2025-02/Tentaschema%20VT%202025%20%20februari%20-%20augusti%202025%20extern%20hemsida%202025-02-06.pdf - 2026-05-23

Den här artikeln är över 5 år gammal, och informationen kan därför vara inaktuell. Lunds universitet och avdelningen Forskningsservice bjuder in till mingel med några av de lundaforskare som erhållit ERC-anslag, det kanske mest prestigefulla forskningsanslaget i Europa. Minglet äger rum på Pufendorfinstitutet den 15 mars, klockan 16:00. ERC, European Research Council, tilldelar löpande ut anslag t

https://www.lu.se/artikel/lunds-universitet-bjuder-till-mingel-med-toppforskare - 2026-05-23

Brevmall Sektionen HR Avgifter fr.o.m. 1 januari 2022 Personer födda 1937 eller tidigare Personer födda 1938 -- 1956 Personer födda 1957 -- 1987 Personer födda 1988-- Arbetsgivaravgift 31,42 % 31,42 % (10,21 % för de födda 2004-2006 och 19,73% för de födda 1999-2003. 19,73% är tillfälliga regler som gäller t o m 31 mars 2023. Båda ålderskategorierna gäller lön upp till 25 000 kr/mån, 31,42% för er

https://www.hr-webben.lu.se/sites/hr-webben.lu.se/files/2025-12/211220%20Avgifter%202022%20SLUTLIG.pdf - 2026-05-23

The gene for an IgA-binding protein from a group A streptococcal strain was cloned and expressed in Escherichia coli. The IgA-binding protein, called protein Arp, was purified on IgA-Sepharose, allowing complete purification in a single step. Analysis of protein Arp by Western immunoblotting demonstrated a major IgA-binding band, with an apparent molecular weight of 42 kD. The purified protein was