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Syftet med studien är att utforska det förbättrade upptaget av det radioaktiva spåret Technetium-99m-DTPA (99mTc-DTPA) i råtta Muskelvävnad i Fischer 344 råttor efter applicerad elektriskpulser med 1000 V / cm fältstyrka, 100 μs pulslängd och olika antal pulser.Metoder: 99mTc-DTPA (totalt 150 MBq) administrerades intramuskulärt (i.m.) vidaxel som en bolus i flera fraktioner av 50 l vardera i inte
Background & Purpose: Radiation therapy is an essential treatment for cancer patients with the ultimate goal to deliver radiation doses to the tumour with precision while minimizing exposure to surrounding healthy tissues. Treatment verification is crucial to ensure the accuracy of radiation delivery, for instance by measuring the radiation dose distribution. Among various dosimetry techniques
Popular Abstract in English 111-Indium is a radioactive isotope that can be chemically linked to different molecules. When this compound is given to patients is distributed heterogeneously within the structures that build up the testicle. Different parts of the so-called germ cells are sensitive to radiation in different ways. Therefore, if a radioisotope that send out electrons with low energies It is well known that the testicles are among the most radiosensitive tissue, and constitute an important critical target for both external and internal radiation during diagnostic and therapeutic use of radionuclides. In systemic radionuclide therapy where very high activities are administered, the testis may become a dose-limiting organ; often with a complex, non-uniform activity distribution an
IMPORTANCE In age-related macular degeneration (AMD), rare variants in the complement system have been described, but their functional consequences remain largely unexplored. OBJECTIVES To identify new rare variants in complement genes and determine the functional effect of identified variants on complement levels and complement regulation in serum samples from carriers and noncarriers. DESIGN, SE
Popular Science SummaryPolymers are giant molecules consisting of a repetition of many small units (monomers) that are linked together by chemical bonds. If we consider a long necklace as a polymer chain, the beads are the monomers and the part of the thread which connects the beads together is the chemical bond. Polymers are important materials in our everyday life and they can be found e.g., in This thesis incorporates studies on the aqueous systems of two types of thermoresponsive amphiphilic block copolymers; a series of nonionic triblock copolymers comprising blocks of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) denoted as PEO-PPO-PEO block copolymers, and a series of ionic diblock copolymers consisting of one charged block and one block of poly(N-isopropylacrylamide) (
Popular Abstract in Swedish Undersøkelsen omfatter 44 skandinaviske personer med Laurence-Moon-Bardet-Biedl syndrom. Disse personer hadde netthinne degenerasjon og minst ytterligere 2 av de øvrige tradisjonelle tegn på lidelsen: overvekt, overtallige fingre og tær, mangelfullt utviklede kjønnsorganer og nedsatt intelligens. Undersøkelsen viste at pasientene fikk nattblindhet og avtagende syn i barThe study included 44 Scandinavian individuals with the autosomal recessive inherited Laurence-Moon-Bardet-Biedl syndrome. Inclusion criteria were retinal dystrophy plus at least 2 more of the remaining traditional cardinal signs of the syndrome: obesity, polydactyly, hypogenitalism and mental retardation. The study showed that the patients had an early onset of night blindness and a poor visual p
Popular Abstract in Swedish Identifiering av ärftlig äggstockscancer har stor klinisk relevans för att förhindra nya tumörer hos individen och i familjen. Möjligheten att förhindra bröstcancer i BRCA familjer genom kontrollprogram och profylaktisk kirurgi är välkänd, medan möjligheten att förhindra tarmcancer och livmodercancer i HNPCC familjer är mindre känd. Studierna i denna avhandling har kunnOvarian cancer is a leading cause of gynecological cancer death and in Sweden nearly 700 cases are diagnosed annually. Ovarian cancer has one of the highest frequencies of hereditary cancer. This thesis focuses on estimates of the contribution of hereditary breast and ovarian cancer (HBOC) and hereditary nonpolyposis colorectal cancer (HNPCC) to the development of ovarian cancer and investigates t
Inhaled corticosteroid (ICS) therapy is central to the long-term management of asthma and is extensively used in the management of chronic obstructive pulmonary disease (COPD). While administration via inhalation limits systemic exposure compared with oral or injected corticosteroids and, therefore, the risk of systemic corticosteroid-related adverse effects, concerns over the long-term safety of
BACKGROUND: Because hemodilution decreases the oxygen-carrying capacity of blood, it was hypothesized that severe hemodilution would decrease the tolerance to alveolar hypoxia. METHODS: Hemodynamics, oxygen transport, and blood lactate concentrations were compared in ten pigs with normal hematocrit (33 +/- 4%), and ten hemodiluted pigs (hematocrit 11 +/- 1%; mean +/- SD) anesthetized with ketamine
Objective: To evaluate under- and overreporting and their determinants in the EPIC :24-hour diet recall (24-HDR) measurements collected in the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: Cross-sectional analysis. 24-HDR measurements were obtained by means of a standardised computerised interview program (EPIC-SOFT). The ratio of reported energy intake (EI) to estim
The European spruce bark beetle is considered as one of the most destructive forest insects to Norway spruce trees in Europe. Climate change may increase the frequency and intensity of bark beetle outbreaks. It is therefore of vital importance to detect the bark beetle outbreaks and take it under control to prevent further damages. Remote sensing techniques may provide a cost-efficient solution to
Salinisation is a global issue which leads to desertification and soil degradation and exposure to salt is also known to inhibit microbial activity and plant growth. This study was conducted to determine the influence of salinity on microbial activity of a non- saline soil. By using Salt Induced Community Tolerance (SICT) concept I found that microbial community tolerance to salt can be induced in
The ever increasing data rates in wireless communication require analog to digital converters (ADCs) with greater requirements on speed and accuracy, while being power efficient to prolong battery life. This dissertation contains an introduction to the field and five papers that focus on the continuous-time (CT) Delta-Sigma modulator (DSM) as ADC. Paper I analyses the performance degradation of d
Sammanfattning Bakgrund: Axelsmärta är vanligt förekommande inom handboll med en rapporterad punktprevalens mellan 19-36% innan säsongsstart och medelprevalens under en träningsvecka när det är säsong på 28%. Olika riskfaktorer har diskuterats där inskränkt rörlighet i axelleden är en av dem. Ett handbollskast kan uppmäta 130km/h med en boll som väger nästan ett halvt kilo och detta ställer stora
Anaerobic digestion (AD) of wastes and residues is a widely applied and explored process. However, when the process is not optimized, inadequate concentrations of nutrients and inhibitory compounds are common and can lead to low maximum organic loading rates and increased risk of process problems, low organic dry solids degradation rate and reduced methane yields. To overcome process instability a
Background: One of the polymer gel dosimeters available today is the N-isopropylamide (NIPAM) polymer gel dosimeter which has a less toxic monomer compared to other polymer gels and the advantage of being able to be manufactured under normal oxygen levels. Polymer gel dosimeters in general are advantageous independent dosimeters to use for verification of new radiation treatment techniques due to
Populärvetenskaplig sammanfattning Kalksten är en av våra viktiga geologiska resurser och har genom historien använts till byggnadsmaterial, jordbruk och inom modern industri. Kalksten i alla dess former har varit en viktig del av människans kulturella och teknologiska utveckling. Ett av alla dess användningsområden är som flussmedel vid bearbetning av järnmalm; bränd kalk tillsätts när malmen smäQuicklime (CaO) is an important geological resource with a wide variety of industrial uses. It is a base chemical produced from the burning of limestone or dolomite. This process is referred to as calcination, during which the limestone is heated to temperatures of 900 °C or higher, resulting in the discharge of CO₂, leaving a yield of quicklime. The formula can be written as follows: Limestone:
Intracerebral haemorrhage and small vessel ischaemic stroke (SVS) are the most acute manifestations of cerebral small vessel disease, with no established preventive approaches beyond hypertension management. Combined genome-wide association study (GWAS) of these two correlated diseases may improve statistical power to detect novel genetic factors for cerebral small vessel disease, elucidating unde
Vehicles equipped with sensors can participate in mobile crowdsourcing applications. Vehicular Ad Hoc Networks (VANETs) based on Dedicated Short Range Communication (DSRC) are used to carry sensing data. However, multi-hop transmissions for gathering data to Road Side Units (RSUs) in VANETs suffer from low data rate and long end-to-end delay, which can hardly meet the QoS requirements of delay-senVehicles equipped with sensors can participate inmobile crowdsourcing applications. Vehicular Ad Hoc Networks(VANETs) based on Dedicated Short Range Communication(DSRC) are used to carry sensing data. However, multi-hoptransmissions for gathering data to Road Side Units (RSUs) inVANETs suffer from low data rate and long end-to-end delay,which can hardly meet the QoS requirements of delay-sensitive
Background: Dietary advice remains the cornerstone of prevention and management of type 2 diabetes (T2D). However, understanding the efficacy of dietary interventions is confounded by the challenges inherent in assessing free living diet. Here we profiled dietary metabolites to investigate glycaemic deterioration and cardiometabolic risk in people at risk of or living with T2D. Methods: We analyse
