The mechanism of HAMLET-induced cell death - cellular signalling, oncogenes and clinical perspectives
Popular Abstract in Undetermined 1971 förklarade president Richard Nixon, som så många amerikanska presidenter före honom, krig. Nixons fiende var dock något oortodox; Nixon förklarade krig mot cancer. I och med att senaten godkände ”National Cancer Act”, av pressen snabbt döpt till ”War on cancer”, hoppades Nixon att kunna utradera cancer med hjälp av kraftigt ökade anslag till cancerforskning koDespite recent advances in cancer treatment, truly innovative approaches are required to move beyond the modest benefits achieved to date. HAMLET is a human protein-lipid complex originally discovered in breast milk able to kill a wide range of tumour cells while leaving healthy, differentiated cells unaffected. The aim of this thesis was to identify mechanisms dictating HAMLET sensitivity and to
