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OBJECTIVE-The incretin hormone GIP (glucose-dependent insulinotropic polypeptide) promotes pancreatic beta-cell function by potentiating insulin secretion and beta-cell proliferation. Recently, a combined analysis of several genome-wide association studies (Meta-analysis of Glucose and Insulin-Related Traits Consortium [MAGIC]) showed association to postprandial insulin at the GIP receptor (GIPR)
Data on the role of dietary factors in endometrial cancer development are limited and inconsistent. We applied a "nutrient-wide association study" approach to systematically evaluate dietary risk associations for endometrial cancer while controlling for multiple hypothesis tests using the false discovery rate (FDR) and validating the results in an independent cohort. We evaluated endometrial cance
In contrast to the upfront setting in which the role of high-dose therapy with autologous hematopoietic cell transplantation (HCT) as consolidation of a first remission in patients with multiple myeloma (MM) is well established, the role of high-dose therapy with autologous or allogeneic HCT has not been extensively studied in MM patients relapsing after primary therapy. The International Myeloma
Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2
Reproducible climate reconstructions of the Common Era (1 CE to present) are key to placing industrial-era warming into the context of natural climatic variability. Here we present a community-sourced database of temperature-sensitive proxy records from the PAGES2k initiative. The database gathers 692 records from 648 locations, including all continental regions and major ocean basins. The records
Background: Diet- and physical activity-based interventions in pregnancy have the potential to alter maternal and child outcomes. Objectives: To assess whether or not the effects of diet and lifestyle interventions vary in subgroups of women, based on maternal body mass index (BMI), age, parity, Caucasian ethnicity and underlying medical condition(s), by undertaking an individual patient data (IPD
Background: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glyca
Atmospheric carbon dioxide enrichment (eCO2) can enhance plant carbon uptake and growth1–5, thereby providing an important negative feedback to climate change by slowing the rate of increase of the atmospheric CO2 concentration6. Although evidence gathered from young aggrading forests has generally indicated a strong CO2 fertilization effect on biomass growth3–5, it is unclear whether mature fores
Type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD) often co-occur. Defining causal pathways underlying this relationship may help optimize the prevention and treatment of both diseases. Thus, we assessed the strength and magnitude of the putative causal pathways linking dysglycemia and fatty liver, using a combination of causal inference methods.Measures of glycemia, insulin dynam
During the last glacial–interglacial cycle, Arctic biotas experienced substantial climatic changes, yet the nature, extent and rate of their responses are not fully understood1–8. Here we report a large-scale environmental DNA metagenomic study of ancient plant and mammal communities, analysing 535 permafrost and lake sediment samples from across the Arctic spanning the past 50,000 years. Furtherm
Recent epidemiological studies have suggested a positive association between ultra-processed food consumption and breast cancer risk, although some studies also reported no association. Furthermore, the evidence regarding the associations between intake of food with lower degrees of processing and breast cancer risk is limited. Thus, we investigated the associations between dietary intake by degre
Known risk loci for endometrial cancer explain approximately one third of familial endometrial cancer. However, the association of germline copy number variants (CNVs) with endometrial cancer risk remains relatively unknown. We conducted a genome-wide analysis of rare CNVs overlapping gene regions in 4115 endometrial cancer cases and 17,818 controls to identify functionally relevant variants assoc
Context: The role of glucagon-like peptide-1 (GLP-1) in type 2 diabetes (T2D) and obesity is not fully understood. Objective: We investigate the association of cardiometabolic, diet, and lifestyle parameters on fasting and postprandial GLP-1 in people at risk of, or living with, T2D. Methods: We analyzed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on P
Here we report the results from exploratory analysis using a Bayesian network approach of data originally derived from a large North European study of type 2 diabetes (T2D) conducted by the IMI DIRECT consortium. 3029 individuals (795 with T2D and 2234 without) within 7 different study centres provided data comprising genotypes, proteins, metabolites, gene expression measurements and many differen
A Human Rights-Based Approach to Just Energy Transition in Indonesia POLICY BRIEF The Raoul Wallenberg Institute of Human Rights and Humanitarian Law (RWI) is a research and academic institution committed to the education and development of human rights throughout the world. With more than 30 years of research and program implementation experience, our organizational strategy currently focuses on
https://rwi.lu.se/wp-content/uploads/2024/06/HRBA-to-Just-Energy-Transition.pdf - 2026-05-11
Master’s Dissertation Engineering Acoustics LOVE KLASSON Report TV BA -5054 LO V E K LA SSO N STU D IE O M EN FÖ R B Ä TTR A D TA LU PPFA TTN IN G I K LA SSR U M M ED A V SEEN D E PÅ B A R N M ED C O C H LEA IM PLA N TA T STUDIE OM EN FÖRBÄTTRAD TALUPPFATTNING I KLASSRUM MED AVSEENDE PÅ BARN MED COCHLEAIMPLANTAT TVBA-5054HO.indd 1TVBA-5054HO.indd 1 2018-11-07 18:12:112018-11-07 18:12:11 DEPARTMENT
https://www.akustik.lth.se/fileadmin/tekniskakustik/publications/tvba5000/webTVBA5054.pdf - 2026-05-11
Modelling Ground Vibrations in Abaqus using Python Master’s Dissertation Structural Mechanics Report TV SM -5278 A RG ETA JU PO LLI M O D ELLIN G G R O U N D V IB R A TIO N S IN A B A Q U S U SIN G PY TH O N ARGETA JUPOLLI MODELLING GROUND VIBRATIONS IN ABAQUS USING PYTHON DEPARTMENT OF CONSTRUCTION SCIENCES DIVISION OF STRUCTURAL MECHANICS ISRN LUTVDG/TVSM--25/5278--SE (1-74) | ISSN 0281-6679 MAS
https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5278.pdf - 2026-05-11
Electroweak measurements performed with data taken at the electron positron collider LEP at CERN from 1995 to 2000 are reported. The combined data set considered in this report corresponds to a total luminosity of about 3 fb(-1) collected by the four LEP experiments ALEPH, DELPHI, 13 and OPAL, at centre-of-mass energies ranging from 130 GeV to 209 GeV. Combining the published results of the four L
Popular Abstract in Swedish Min avhandling handlar om flyttning, det vill säga hur levande organismer rör sig mellan olika områden för att utnyttja resurser, undvika födobrist och som en anpassning till klimat- och miljöfaktorer. Vi begränsar det hela till fåglar's flyttning och bland dem ska vi koncentrera os's på rovfåglar. Rovfåglar är beroende av sina bytesdjur, som till exempel kan vara andraMy dissertation is about bird migration and addresses questions about how raptors adapt to the fluctuating environments during the transition seasons between breeding and wintering. The migration is highly affected by local prey abundance, foraging strategies, weather conditions and landscape patterns along the migration routes as well as navigation and orientation mechanisms and cues. Interesting
Popular Abstract in Swedish Det är idag välkänt att patienter med kärlsjukdom i benen har en rad problem som kan påverka deras livskvalitet. Studier har visat att de vanligaste problemen för dessa patienter är trötthet, smärta och begränsad rörelseförmåga. Det är även välkänt att en lyckad kärlkirurgisk behandling ger en snar förbättring av livskvaliteten. Emellertid är kunskapen om varaktigheten The overall aim of this thesis was to investigate quality of life and the meaning of living with peripheral arterial disease (PAD) before and after revascularization in a long-term and methodological perspective. The sample in the first study consisted of 142 patients with PAD who were planned for a revascularization. Quality of life (QoL) assessment with the Nottingham Health Profile (NHP) was ma
