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The meninges are important for brain development and pathology. Using single-cell RNA sequencing, we have generated the first comprehensive transcriptional atlas of neonatal mouse meningeal leukocytes under normal conditions and after perinatal brain injury. Weidentified almost all known leukocyte subtypes and found differences between neonatal and adult border-associated macrophages, thus highlig
To conduct a survey across European cardiac centres to evaluate the methods used for cerebral protection during aortic surgery involving the aortic arch.
Sperm DNA damage is a useful biomarker for male infertility diagnosis and prediction of assisted reproduction outcomes. It is associated with reduced fertilization rates, embryo quality and pregnancy rates, and higher rates of spontaneous miscarriage and childhood diseases. This review provides a synopsis of the most recent studies from each of the authors, all of whom have major track records in
Universities have long used internationalization to prepare students for a highly interconnected world. Although internationalization has often been associated with mobility, current calls for equity, diversity, and inclusion, and climate consciousness, among other things, require institutions to change this strategy. As a response, curriculum internationalization emerges as a more inclusive and s
Optical genome mapping (OGM) enables high-resolution detection of structural variants (SVs) and copy number aberrations (CNAs) using ultralong DNA molecules and minimal bioinformatics processing. Its diagnostic utility in solid tumors remains underexplored. Whole-genome sequencing (WGS) offers comprehensive variant detection but is resource intensive. This study presents a technical benchmarking o
The global rise in youth mental ill-health is exacerbated by a shortage of clinicians trained in evidence-based care, making it difficult to translate research into effective practice – especially for body dysmorphic disorder (BDD), an adolescent-onset condition that often goes undetected and untreated. This study aimed to explore clinicians’ experiences of participation in an online educational p
Background Hypochondriasis, or health anxiety disorder, is associated with increased mortality, mainly from potentially preventable causes. Substance misuse is a well-known contributor to premature death, yet its relationship with hypochondriasis remains unclear. We assessed the risk of broadly defined substance-related problems in individuals diagnosed with hypochondriasis. Methods This Swedish r
Differences between men and women in cognitive impairment and neurodegeneration are not yet well understood. Although sex differences in brain structure abnormalities, including white matter hyperintensities (WMH) and grey matter (GM) atrophy, have been associated with cognitive decline in the ageing population, the evidence is limited and inconclusive. Therefore, we explored sex differences in br
Study region: The Paranapanema River Basin, located in southeastern Brazil, is characterized by a cascade of large hydropower plants regulated by a nationally coordinated dispatch system. This basin is a representative case of reservoir-regulated rivers in the country, where multiple dams interact to supply electricity while reshaping natural flow regimes. Study focus: This study examines hydropow
Partial-volume effects (PVEs) arise from the limited spatial resolution of PET and SPECT imaging systems, causing the systematic underestimation of activity concentration in structures that may hold critical diagnostic, treatment, or dosimetric information that impacts patient management. Recovery coefficient (RC)-based partial-volume correction (PVC) is one of the simpler approaches used to corre
Background Obsessive-compulsive disorder (OCD) is associated with an increased risk of cardiometabolic disorders. We developed a lifestyle intervention, named LIFT, aimed at improving lifestyle habits (physical activity, diet, alcohol and tobacco use, stress, sleep) and reducing cardiometabolic risk factors in OCD. Aims This study aimed to establish the feasibility and acceptability of LIFT, evalu
Many animals undergo irreversible ontogenetic color changes (OCCs), yet these changes are often overlooked despite their potential ethological relevance. The problem is compounded when OCCs involve wavelengths invisible to humans. Wall lizards can perceive ultraviolet (UV) light, and their conspicuous ventral and ventrolateral coloration—including UV-reflecting patched—likely serves social communi
Background: Patients undergoing allogeneic haematopoietic stem cell transplantation (allo-HCT) often face complex and evolving needs throughout recovery. Person-centred nursing (PCN) is essential in this context yet remains underexplored in specialised care settings. In Sweden, the Assessment of Rehabilitation Needs Checklist (ARNC) is commonly used in cancer care, but its role in supporting perso
The Sulu Archipelago, nestled between Mindanao and Borneo, has been a melting pot of people and cultures for thousands of years. Major sociopolitical changes marked its history, attracting groups of people or forcing drastic dispersals. Today, the islands host various ethnolinguistic groups, including Sama-Badjaw and Tausug-speaking communities. We surveyed the literature from multiple disciplines
1. Responses of zooplankton to nutrient enrichment and fish predation were studied in 1998 and 1999 by carrying out parallel mesocosm experiments in six lakes across Europe. 2. Zooplankton community structure, biomass and responses to nutrient and fish manipulation showed geographical and year-to-year differences. Fish had a greater influence than nutrients in regulating zooplankton biomass and es
Smoking is widely considered a risk factor for future fracture. The aim of this study was to quantify this risk on an international basis and to explore the relationship of this risk with age, sex and bone mineral density (BMD). We studied 59,232 men and women (74% female) from ten prospective cohorts comprising EVOS/EPOS, DOES, CaMos, Rochester, Sheffeld, Rotterdam, Kuopio, Hiroshima and two coho
Abstract in Spanish A pesar de que el mercado laboral sueco ha permanecido relativamente intacto durante la crisis económica en los últimos seis años, la integración de personas con capacidad laboral reducida a causa de discapacidades es significativamente menor que la de otros grupos sociales. La legislación sueca sobre discapacidad y trabajo cubre varios aspectos en medidas de integración, antidEven though the Swedish labour market has been more or less intact during the financial crisis in the past six years, persons with reduced working capacity due to disabilities are significantly less integrated in the labour market than other groups in society. Swedish legislation on disability and work provides for a number of different aspects of integrative measures, anti-discrimination and prov
The etiology of Langerhans cell histiocytosis (LCH), a disease characterized by uncontrolled proliferation of Langerhans cells, is unknown. Although some believe that LCH is reactive, others support a neoplastic origin. We tested the hypothesis that LCH is neoplastic by investigating potential consistent chromosomal aberrations in LCH cells. We used multiparameter DNA flow cytometry to analyze the
The interest in phasor measurement technology has reached a peak in recent years, as the need for the best estimate of the power system's state is recognized to be a crucial element in improving its performance and its resilience in the face of catastrophic failures. In most countries installing the phasor measurement units (PMUs) and getting to know the PMU system behavior through continuous obse
