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This paper describes the diagnostic criteria for presbyvestibulopathy (PVP) by the Classification Committee of the Bárány Society. PVP is defined as a chronic vestibular syndrome characterized by unsteadiness, gait disturbance, and/or recurrent falls in the presence of mild bilateral vestibular deficits, with findings on laboratory tests that are between normal values and thresholds established fo

Background Isolated (sub)acute chorea in young patients is a relatively rare movement disorder with a broad differential diagnosis, including drug-induced, post-infectious, auto-immunological and vascular aetiologies. Case presentation We describe an adolescent girl with Down's syndrome presenting with chorea due to oral contraceptive usage. After discontinuation of the oral contraceptive it took

Phosphohydroxylysinuria has been described in two patients with neurological symptoms, but the deficient enzyme or mutated gene has never been identified. In the present work, we tested the hypothesis that this condition is due to mutations in the AGXT2L2 gene, recently shown to encode phosphohydroxylysine phospholyase. DNA analysis from a third patient, without neurological symptoms, but with an

Case: A 34-year-old woman was referred to our hospital with progressive movement disorders and neurodegeneration with brain iron accumulation and enlargement of the frontal diploe on the MRI. Metabolic testing revealed that she had α-mannosidosis (AMD), a lysosomal storage disorder. Background: AMD is a rare genetic disorder that causes α-mannosidase deficiency resulting in lysosomal accumulation

The issue of Critical Raw Materials (CRMs) and potential interruptions to their availability due to shortages, trade restrictions or other factors in their supply are topics that are relatively unknown to the general public. For this reason, education has been promoted as a key enabler of a circular economy. One key intervention point is the movement of electronic repair events. Repair events alre

Sex differences in ecologically important traits are common in animals and plants, and prompted Darwin to first propose an ecological cause of sexual dimorphism. Despite theoretical plausibility and Darwin's original notion, a role for ecological resource competition in the evolution of sexual dimorphism has never been directly demonstrated and remains controversial. I used experimental evolution

During vertebrate embryonic development, cellular senescence occurs at multiple locations. To date, it has been accepted that when there has been induction of senescence in an embryonic tissue, β-galactosidase activity is detectable at a pH as high as 6.0, and this has been extensively used as a marker of cellular senescence in vivo in both whole-mount and cryosections. Such senescence-associated

We prove that for k ≫; 4√n regular resolution requires length nω(k) to establish that an ErdÅ's-Rényi graph with appropriately chosen edge density does not contain a k-clique. This lower bound is optimal up to the multiplicative constant in the exponent and also implies unconditional nω(k) lower bounds on running time for several state-of-the-art algorithms for finding maximum cliques in graphs.

U-Pb geochronology on baddeleyite is a powerful technique that can be applied effectively to chronostratigraphy. In southern Africa, the Kaapvaal Craton hosts a well-preserved Mesoarchean to Paleoproterozoic geological record, including the Neoarchean Ventersdorp Supergroup. It overlies the Witwatersrand Supergroup and its world-class gold deposits. The Ventersdorp Supergroup comprises the Klipriv

Dimethyl sulfide (DMS) is the dominant biogenic sulfur compound in the ambient marine atmosphere. Low-volatility acids from DMS oxidation promote the formation and growth of sulfur aerosols and ultimately alter cloud properties and Earth's climate. We studied the OH-initiated oxidation of DMS in the Aarhus University Research on Aerosol (AURA) smog chamber and the marine boundary layer (MBL) with

The dynamical evolution of globular clusters (GCs) is tied to their binary population, as binaries segregate to the cluster centre, leading to an increased binary fraction in the core. This central overabundance of mainly hard binaries can serve as a source of energy for the cluster and has a significant effect on the observed kinematics, such as artificially increasing the observed line-of-sight

Partially premixed combustion using gasoline-like fuels on compression ignition engines shows great potentials to break the soot-nitrogen oxides trade off and reduce both emissions simultaneously. By simply adjusting the dilution strategies and injection events, the control of partially premixed combustion is relatively easier compared to other low-temperature combustion concepts. However despite

The recently funded, five-year, project Melody in Human–Cat Communication (Meowsic) has received vast media attention, both nationally and around the world. In this paper we summarize how our activities got started, our published results so far, the present situation and how we envision our planned, future research, including some of the core hypotheses to be addressed by the project.

Resting energy expenditure (REE) was investigated in 8 children with propionic and methylmalonic acidaemias because a lowered REE has been reported in the literature. We observed a marginally elevated REE and think that adequate caloric intake and the use of a synthetic amino acid mixture are responsible for this.

Hemolysins are cytolytic proteins which have been extensively characterized at the molecular level, however, their in vivo functions remain unclear. This study analyzed the association of hemolysin production with the inflammatory response in patients with urinary tract infection (UTI). Infants and children with their first episode of UTI (n = 644) were followed prospectively. The body temperature

Machine Learning (ML) applications shape, and are shaped by, human values. In the last decade classificatory models have become the most widely applied type of ML. However, since the invention of Generative Adverserial Networks (GANs) in 2014, the field of generative ML is likely to become equally prolific in the years to come. GANs can generate convincing fakes of video footage, pictures, graphic

IntroductionSelf efficacy (SE) relates to pupils' beliefs about their own capacities within a given field. It has been shown that an overestimation of one's own SE beliefs affects learning outcomes negatively. In the present study we examine SE beliefs in writing skills in two groups of secondary school pupils, one with hearing impairment, the other without.PurposeText writing is a complex skill,

The electronic spectra of three rhombic type 1 blue copper proteins, nitrite reductase, pseudoazurin, and cucumber basic protein, have been studied by ab initio multiconfigurational second-order perturbation theory (the CASPT2 method). The six lowest excitations have been calculated and assigned with an error of less than 1800 cm-1. The singly occupied orbital in the ground-state forms a strongly