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L'histoire, il s'agit d'une famille en Suede qui veut aller en Italie pour une semaine. Dans la famille il y a Lisa, qui a 15 ans et sa mère. Ca commence un matin. La famille Andersson mange le petit dejuner ensemble et ils parlent de faire un voyage pendant le vacance en avril, c'est le vacance de Paques. Lisa, la petite file dans la famille, a pensé qu'Italie était la meilleure pays en Europe, p

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The Difficult Art of Learning from the Holocaust

Both the connections between then, present and then and the question of how scholarly history (the historical past) can interact or sometimes be replaced by other forms of historical production and dissemination (the practical past) are important components. The fundamental question is whether – and if so, how – we can learn from the atypical and multifaceted Holocaust in many respects. A starting

Functional C1-inhibitor diagnostics in hereditary angioedema: Assay evaluation and recommendations

Hereditary angioedema (HAE) is an autosomal dominant disease characterized by recurrent episodes of potentially life-threatening angioedema. The most widespread underlying genetic deficiency is a heterozygous deficiency of the serine protease inhibitor Cl esterase inhibitor (C1-Inh). In addition to low C4 levels, the most important laboratory parameter for correct diagnosis of HAE or angioedema du

C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain

C(4)-dicarboxylates are the major carbon and energy sources during the symbiotic growth of rhizobia. Responses to C(4)-dicarboxylates depend on typical two-component systems (TCS) consisting of a transmembrane sensor histidine kinase and a cytoplasmic response regulator. The DctB-DctD system is the first identified TCS for C(4)-dicarboxylates sensing. Direct ligand binding to the sensor domain of