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Proteolysis of purified IgGs by human and bacterial enzymes in vitro and the detection of specific proteolytic fragments of endogenous IgG in rheumatoid synovial fluid
A comparative in vitro survey of physiologically relevant human and microbial proteinases defined a number of enzymes that induced specific hinge domain cleavage in human IgG1. Several of these proteinases have been associated with tumor growth, inflammation, and infection. A majority of the identified proteinases converted IgG to F(ab')(2), and a consistent feature of their action was a transient
A 24-GHz Automotive Radar Transmitter with Digital Beam Steering in 130-nm CMOS
Pigment dispersion processing, optimization for higher pigmentation
One way to make a UV curable ink is to mix a pigment dispersion with monomers, oligomers, photoinitiators and additives. Creating a pigment dispersion is in many cases the first processing step of making a UV curable ink and is of large importance. To process pigment dispersions of Pigment red 2 and Pigment red 122 a premixing step with a dissolver is used followed by a grinding step employing a t
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Exercise restores decreased physical activity levels and increases markers of autophagy and oxidative capacity in myostatin/activin-blocked mdx mice
Factor H–IgG chimeric proteins as a therapeutic approach against the gram-positive bacterial pathogen Streptococcus pyogenes
Bacteria can cause life-threatening infections, such as pneumonia, meningitis, or sepsis. Antibiotic therapy is a mainstay of treatment, although antimicrobial resistance has drastically increased over the years. Unfortunately, safe and effective vaccines against most pathogens have not yet been approved, and thus developing alternative treatments is important. We analyzed the efficiency of factor