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The value of bone mineral density (BMD) measurements to stratify fracture probability can be enhanced in a case-finding strategy that combines BMD measurement with independent clinical risk indicators. Putative risk indicators include age and gender, BMI or weight, prior fracture, the use of corticosteroids, and possibly others. The aim of the present study was to develop a mathematical framework

The challenges for creating a greener economy and the institutional framework for sustainable development pass necessarily, or mostly, through cities, as they concentrate a large and growing part of the world’s economy and population, as well as decision-making power. With the processes of urbanization and rural-urban transformation, the economy in cities, especially in cities of developing countr

The systemic vasculitides are multisystem disorders with considerable mortality and morbidity and frequent relapses. In the absence of reliable serological markers, accurate clinical tools are required to assess disease activity and damage for treatment decisions, and for the performance of clinical trials. This article reviews and summarises the development and use of disease assessment tools for

Background and Objectives Antibodies to antigens in the Kell blood group system, especially anti-KEL1, are involved in both haemolytic disease of the newborn and foetus and haemolytic transfusion reactions. Correct typing results are important and discrepancies between serologic and genetic typing must be resolved. Here, we describe the investigation of three healthy individuals who were initially

In this paper, we consider both algebraic crossed products of commutative complex algebras A with the integers under an automorphism of A, and Banach algebra crossed products of commutative C*-algebras A with the integers under an automorphism of A. We investigate, in particular, connections between algebraic properties of these crossed products and topological properties of naturally associated d

Weak convergence of the multivariate point process of upcrossings of several high levels by a stationary Gaussian process is established. The limit is a certain multivariate Poisson process. This result is then used to determine the joint asymptotic distribution of heights and locations of the highest local maxima over an increasing interval. The results are generalized to upcrossings and local ma

Det är många maskiner och människor engagerade i en avverkning där man tar ut virke, grot och stubbar. En serie djupintervjuer med olika intressenter och aktörer visar att det finns stora brister i planering, logistik och kommunikation mellan de olika leden i kedjan, speciellt då flera olika entreprenörer är inblandade. Svaren visar också att det finns ett behov av bättre utbildning – och att man

Positive allosteric modulators of the ionotropic glutamate receptor-2 (GluA2) are promising compounds for the treatment of cognitive disorders, e.g. Alzheimer's disease. These modulators bind within the dimer interface of the LBD (ligand-binding domain) and stabilize the agonist-bound conformation slowing receptor desensitization and/or deactivation. In the present study, we employ isothermal titr

BACKGROUND/AIMS: Mobility disability (MD) and obesity are conditions which have been associated with weaker labour market attachment. This study investigates whether the combined burden of MD and obesity increase the risk of disability pension compared with having only one of these conditions (the reference group).METHODS: A nationwide cohort study, based on national surveys made between 1996 and

I bokens åttonde kapitel relaterar Gregor Noll bokens tema om nya säkerhetshot till den aktuella frågan om EU:s hantering av flyktingar och asylsökande. Kapitlets tes är att EU:s invandrings- och asylpolitik ytterst utgör en protektionistisk ordning med utgångspunkt i nationalstatens kontrollbehov. Noll menar att denna ordning manifesterade sig redan vid unionens tillkomst under femtiotalet. De nu

The struggle for equality is fundamental to the reduction of poverty in Central America. Besides, one of the foremost goals of urban spatial planning, when implementing social policies, is to contribute to the reduction of poverty. This is done by producing a list of territorially-based actions and selecting those suitable for the implementation of social policies developed at national level. Howe

The electronic spectrum of the azurin Met121Gln mutant, a model of the blue copper protein stellacyanin, has been studied by ab initio multiconfigurational second-order perturbation theory (the CASPT2 method), including the effect of the protein and solvent by point charges. The six lowest electronic transitions have been calculated and assigned with an error of less than 2400 cm-1. The ground-sta

Definitive hematopoiesis emerges via an endothelial-to-hematopoietic transition in the aorta-gonad-mesonephros (AGM) region and placenta. We have recently demonstrated the induction of hematopoietic stem/progenitors (HSPCs) from mouse fibroblasts with a combination of transcription factors progressing through endothelial-like precursors. Here, guided by our in vitro programming experiments we anal