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Reversible phosphorylation is an important regulatory mechanism. Regulation of protein phosphorylation in β-cells has been extensively investigated, but less is known about protein dephosphorylation. To understand the role of protein dephosphorylation in β-cells and type 2 diabetes (T2D), we first examined mRNA expression of the type 2C family (PP2C) of protein phosphatases in islets from T2D dono

Instituting (Athens, 2021)What could processes of self-organizing and collective making look like in the current landscape? In what ways might they affect public processes of social improvisation? How might such forms of “instituting” give rise to other forms of institutions? Inviting theoretical as well as practical approaches, this edition of the New Alphabet School studies “instituting” as an i

Objective: Non-coding RNAs constitute a major fraction of the β-cell transcriptome. While the involvement of microRNAs is well established, the contribution of long non-coding RNAs (lncRNAs) in the regulation of β-cell functions and in diabetes development remains poorly understood. The aim of this study was to identify novel islet lncRNAs differently expressed in type 2 diabetes models and to inv

Et segment af danske muslimer med rødder i lande, der anvender islamisk lov, anser den islamiske vielse (nikah) og den borgerlige vielse for at være to separate vielser, der kræver to separate skilsmisser. I den forbindelse anses Familieretshusets domsmyndighed for utilstrækkelig i forhold til at opløse nikahen, eftersom en nikah-opløsning ifølge nogle muslimer kun kan foretages af en islamisk dom

Non-germinal center (non-GC) phenotype, high level expression of the transcription factor forkhead box protein P1 (FOXP1) and anti-apoptotic protein Bcl-2 have been identified as unfavorable prognostic factors for diffuse large B-cell lymphoma (DLBCL) patients treated with chemotherapy. Our aim was to re-evaluate the prognostic impact of these biologic factors on the survival of the patients treat

Objective: Copy number variation is a common polymorphic phenomenon within the human genome. Although the majority of these events are non-deleterious they can also be highly pathogenic. Herein we characterize five families with parkinsonism that have been identified to harbor multiplication of the chromosomal 4q21 locus containing the a-synuclein gene (SNCA). Methods: A methodological approach us

Performance audit has become increasingly common in the public administration and every western democracy has today an independent National Audit Office (NAO). However, although the external requirements may be met, the functioning of these agencies may be jeopardized by internal and more subtle cultural factors relating to the role of the performance auditor. In Sweden, a new NAO called Riksrevis

Popular Abstract in Swedish I denna avhandling har jag undersökt hur man kan utöka det dynamiska omfånget utan att öka noggrannheten i en analog-till-digital omvandlare med en flyttalsliknande lösning. Den valda lösningen går ut på att man förstärker en analog insignal med flera oberoende analoga förstärkare med skilda förstärkningar. Sedan väljs den förstärkare som ger den starkaste utsignalen s

Oxidative stress has been implicated as an important factor in the progression of many diseases. An imbalance in the redox-system may cause oxidation of cells and molecules, which might subsequently lead to tissue damage. The research presented in this thesis has focused on elucidating a possible involvement of the human protein alpha-1-microglobulin in the defence against pathological oxidation.

The present thesis is aimed to examine the hypothesis that the degree of vascular inflammation correlates with the expression of vascular endothelin and angiotensin receptors. The receptor changes were studied in subcutaneous resistance arteries in patients with different degrees of ischemic heart disease (IHD). In addition, patients with giant cell arteritis (GCA) were also investigated because o

What conformations do protein molecules populate in solution? Crystallography provides a high-resolution description of protein structure in the crystal environment, while NMR describes structure in solution but using less data. NMR structures display more variability, but is this because crystal contacts are absent or because of fewer data constraints? Here we report unexpected insight into this

Tadpoles from two types of ponds, temporary and permanent, were raised in a common garden experiment. There was no clear effect of pond type on development rate (time for metamorphosis). From each sibship, one group was raised under a constant water regime (deep tanks) and one was subject to simulated pond drying (shallow tanks). The tadpoles exhibited a plastic response to pond drying: they metam

The Department of English in Lund: Working Papers in Linguistics is an annual volume produced by the English Department at Lund University in Sweden. Its main aim is to publicize research being carried out by staff and post-graduate students in the department, but we are also pleased to include contributions from members of neighbouring departments and universities. The contributions in volume 3

This thesis is based upon four original papers describing the characterisation of mantle cell lymphoma (MCL) tumours and cell lines in comparison with different populations of normal B cells. Gene expression profiling, which were used in the studies, has during recent years developed as an important tool in characterisation of different types of malignancies. In this thesis, the technique is used