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Enhancing a de novo enzyme activity by computationally-focused ultra-low-throughput screening
Directed evolution has revolutionized protein engineering. Still, enzyme optimization by random library screening remains sluggish, in large part due to futile probing of mutations that are catalytically neutral and/or impair stability and folding. FuncLib is a novel approach which uses phylogenetic analysis and Rosetta design to rank enzyme variants with multiple mutations, on the basis of predic
De novo DHDDS variants cause a neurodevelopmental and neurodegenerative disorder with myoclonus
Subcellular membrane systems are highly enriched in dolichol, whose role in organelle homeostasis and endosomal-lysosomal pathway remains largely unclear besides being involved in protein glycosylation. DHDDS encodes for the catalytic subunit (DHDDS) of the enzyme cis-prenyltransferase (cis-PTase), involved in dolichol biosynthesis and dolichol-dependent protein glycosylation in the endoplasmic re
Molecular and Morphological Characteristics of the De-Obstructed Rat Urinary Bladder—An Update
Many patients with outlet obstruction secondary to prostatic enlargement have lower urinary tract symptoms (LUTSs) and an increased frequency of micturition. The standard treatment is transurethral resection of the prostate (TURP), which alleviates obstruction and symptoms. However, after TURP, 20–40 percent of patients continue to experience LUTSs. The aim of the present study in rats was to iden
A new de-airing technique that reduces systemic microemboli during open surgery: a prospective controlled study.
Traditional and Digital Building Archaeology, a Balance Between Old and New: A case study of the abbey Saint-Mathieu de Fine-Terre
This thesis aimed to work with different techniques of building archaeology, both traditional and digital. The goal was to define the possibilities offered by the “traditional” and the “digital” building archaeology but also to show the limits of these two methods. The main issue of discussing methodological problems in building archaeology was the need to define digital building archaeology, espe
A literature review of two approaches to ontology within anthropology: a juxtaposition between the ‘ontological turn’ and Marisol de la Cadena’s Earth Beings
Hörmander's inequality and point evaluations in de Branges space
DOGMA : de novo assembly of densely labelled optical DNA maps using a matrix profile approach
Lauréats du Concours Nicati : Concert – SMC Société de Musique Contemporaine, Lausanne (CH)
Concert with Orchestre Philharmonique de Radio France, Festival d'Automne, Paris (FR)
Violaxanthin de-epoxidase, the xanthophyll cycle enzyme, requires lipid inverted hexagonal structures for its activity
Zeros of random functions generated with de branges kernels
The effect of age and emphysematous and fibrotic injury on the re-cellularization of de-cellularized lungs
Paris and Stockholm in the novels Illusions Perdues de Balzac and The Red Room by August Strindberg
De novo synthesis of thiamine (vitamin B1) is the ancestral state in Plasmodium parasites – evidence from avian haemosporidians
Comparison of the effectiveness and safety of a new de-airing technique with a standardized carbon dioxide insufflation technique in open left heart surgery: A randomized clinical trial.
De minimis exception when using applied art in marketing materials
1. In order to prove a copyright exception not contemplated in the Act but based on long-standing practice the defendant must show strong evidence that goes beyond a usual practice in the business.2. The use of a copyright-protected work even in a commercial or marketing context can be of such secondary importance that – notwithstanding that the rights holder has not permitted the use – it would n
