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In 2009, the European Paediatric Study Group for Haemolytic Uraemic Syndrome (HUS) published a clinical practice guideline for the investigation and initial therapy of diarrhea-negative HUS (now more widely referred to as atypical HUS, aHUS). The therapeutic component of the guideline (comprising early, high-volume plasmapheresis) was derived from anecdotal evidence and expert consensus, and the a

Background: Novel peritoneal dialysis solutions are characterized by a minimal content of glucose degradation products and a neutral pH. Many studies have shown the biocompatibility of neutral lactate-buffered solutions; however, until now, the effect of purely bicarbonate-buffered solutions has not been intensively studied in vivo. Methods: This study was an open label, prospective, crossover mul

We utilized femtosecond time-resolved resonant inelastic X-ray scattering and ab initio theory to study the transient electronic structure and the photoinduced molecular dynamics of a model metal carbonyl photocatalyst Fe(CO)5 in ethanol solution. We propose mechanistic explanation for the parallel ultrafast intra-molecular spin crossover and ligation of the Fe(CO)4 which are observed following a

Primary astrocytomas of grade 3 or 4 according to the classification system of the World Health Organization (high-grade astrocytomas or HGAs) are preponderant among adults and are almost invariably fatal despite the use of multimodal therapy. Here we show that the juvenile brain has an endogenous defense mechanism against HGAs. Neural precursor cells (NPCs) migrate to HGAs, reduce glioma expansio

For a level scheme investigation of Gd-142 an experiment with the gamma -spectrometer EUROBALLIII has been carried out and lifetimes have been measured with EUROBALL IV using the Doppler-shift attenuation method. The high-spin states have been populated in these experiments by means of the(99)Ru(Ti-48, 2p3n) reaction at a beam energy of 240MeV and the Sn-114(S-32, 2p2n) reaction at 160MeV, respect

Background Progression of joint destruction in rheumatoid arthritis (RA) is partly heritable; knowledge of genetic factors may increase our understanding of the mechanisms underlying joint destruction. The activity of the Wnt/beta-catenin pathway influences osteoblast differentiation. Dickkopf-1 (Dkk-1) and sclerostin (Sost) are negative regulators and lipoprotein receptor-related protein-5 (LRP-5

Background Interleukin (IL)-15 levels are increased in serum, synovium and bone marrow of patients with rheumatoid arthritis (RA). IL-15 influences both the innate and the adaptive immune response; its major role is activation and proliferation of T cells. There are also emerging data that IL-15 affects osteoclastogenesis. The authors investigated the association of genetic variants in IL15 with t

Detta arbete behandlar frågan om vilken betydelse samtycke har i dagens våldtäktslagstiftning. För att försöka besvara frågan, eller åtminstone belysa problematiken, har jag utgått från vissa förutsättningar i form av lagstiftning, både svensk såväl som engelsk, praxis och en dom från Europa-domstolen. Olika åsikter inom doktrinen presenteras fortlöpande i texten. I den svenska lagstiftningen stäl

Det är svårt att tänka sig ett samhälle utan banker. Ett samhälle där vi skulle få lönen direkt i handen, där vi skulle spara pengar i madrassen och där vi skulle betala räkningar genom att skicka pengar i ett kuvert. En god betalningsförmedling är högt prioriterad i varje modernt samhälle. Vissa risker kan uppstå vid betalningsförmedling. Typexempel på risker är att betalningen sker för sent, att

På den sociala dimensionens område har EU endast kompetens att reglera i form av minimidirektiv. På grund av dessa minimiregler ser arbetsmiljörätten olika ut på nationell nivå i medlemsstaterna, så också i Sverige och Danmark. Syftet med uppsatsen är därför att utreda arbetsgivaransvaret för arbetsmiljön i Sverige respektive Danmark genom en komparativ studie, med betoning på skillnader och med b

Jag har valt att författa mitt examensarbete om när missbruksrelaterad misskötsamhet på arbetsplatserna utgör saklig grund för uppsägning och avsked. Till att börja med utgör sen ankomst, otillåten frånvaro och olika former av olämpligt uppträdande med mera exempel på när misskötsel föreligger. Studiens huvudsakliga mål är att avgöra när alkohol- och narkotika missbruk leder till att arbetstagaren

Summary The paper aims to clarify the rules regarding the personal liability for company representatives and its shareholders. This set of rules can be found in the 25th chapter 13-20 a §§ ABL. Furthermore the aim of the essay is to present news from the legislator and courts, for the area in question. This presentation will provide the basis for answering the question in which direction the appli

Denna uppsats behandlar unga lagöverträdares roll i svensk straffrätt. Syftet med arbetet är att skildra straffbarhetsåldern i svensk rätt. Skildra hur regleringen kommer till uttryck i gällande rätt samt ur ett rättshistoriskt perspektiv. Frågeställningarna för att besvara syftet: Är 15 år en lämplig straffbarhetsålder? Uppfylls förutsägbarhetsprincipen för barn under 15 år vad gäller påföljdssyThis paper deals with young offenders role in Swedish criminal law. The aim is to portray the age of criminal liability in Swedish law. Depict how the regulation is enshrined in the law as well as from a correct historical perspective. The questions to answer the purpose are: Is 15 years an appropriate age of criminal responsibility? Is the principle of predictability fulfilled for children under

Plasma phosphorylated-tau217 (p-tau217) has been shown to be one of the most accurate diagnostic markers for Alzheimer's disease. No studies have compared the clinical performance of p-tau217 as assessed by the fully automated Lumipulse and single molecule array (SIMOA) AlZpath p-tau217. The study included 392 participants, 162 with Alzheimer's disease, 70 with other neurodegenerative diseases wit

Objectives: IgA vasculitis (IgAV) in adults has been relatively under-investigated. Since outcomes are worse in other forms of vasculitis with increasing age, we investigated the outcomes of IgAV comparing younger adults (18-34), middle-aged adults (35-64) and elderly patients (≥64 years) focusing on kidney outcomes. Methods: We identified patients with renal biopsy-confirmed IgAV nephritis and co

Aim: This study aimed to develop a universally applicable core set of quality indicators for Hirschsprung's disease care through a consensus-driven process, to standardise and improve care quality across Europe. Methods: A modified Delphi method was used to achieve consensus among healthcare professionals (HPs) and patient representatives (PRs) across Europe. Participants completed three rounds of

In 2020, fecal (stool) testing was recommended for diagnosing Mycobacterium tuberculosis complex (MTBC) infection in children by using the Cepheid Xpert MTB/RIF assay; since then, countries have begun implementing stool-based testing, often as part of a comprehensive strategy to enhance TB case finding among children. On the basis of an experience-sharing workshop in November 2023, we determined i

We exhibit supercritical trade-off for monotone circuits, showing that there are functions computable by small circuits for which any small circuit must have depth superlinear or even super-polynomial in the number of variables, far exceeding the linear worst-case upper bound. We obtain similar trade-offs in proof complexity, where we establish the first size-depth trade-offs for cutting planes an

Background: Perioperative myocardial injury (PMI) is associated with increased short-term major adverse cardio- and cerebrovascular events (MACCE) and mortality. We evaluated how different phenotypes of PMI based on timing of injury impact long-term MACCE and mortality among patients undergoing major noncardiac surgery (NCS). Methods: A prospective, observational study was carried out in 1290 pati