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BACKGROUND: Elevated pulmonary vascular resistance (PVR) in the setting of left heart failure may contribute to poor outcomes after pediatric heart transplant (HTx), but peri-transplant management is variable.METHODS: We sought to characterize international practice by surveying physicians at pediatric HTx centers.RESULTS: We received 49 complete responses from 39 centers in 16 countries. Most res

Aims: Drug development for paediatric pulmonary arterial hypertension (PAH) ispressingly needed. Experts from the US Food and Drug Administration, EuropeanMedicines Agency, Health Canada, key opinion leaders, academia, patients, and industry representatives held a workshop on 12th June 2017 dedicated to addressing challenges and unmet needs. This report summarises the approaches proposed during th

We significantly strengthen and generalize the theorem lifting Nullstellensatz degree to monotone span program size by Pitassi and Robere (2018) so that it works for any gadget with high enough rank, in particular, for useful gadgets such as equality and greater-than. We apply our generalized theorem to solve three open problems: •We present the first result that demonstrates a separation in proof

Long term effect of testosterone (T) deficiency impairs metabolism and is associated with muscle degradation and metabolic disease. The association seems to have a bidirectional nature and is not well understood. The present study aims to investigate the early and unidirectional metabolic effect of induced T changes by measuring fasting amino acid (AA) levels in a human model, in which short-term

BACKGROUND: During the past 4 decades, there has been a growing focus on preserving the fertility of patients with childhood cancer; however, no large studies have been conducted of live births across treatment decades during this period. Therefore, the authors estimated the potential birth deficit in female childhood cancer survivors and the probability of live births. METHODS: In total, 8886 wom

Hematopoietic stem cells (HSCs) emerge during development from the vascular wall of the main embryonic arteries. The onset of circulation triggers several processes that provide critical external factors for HSC generation. Nevertheless, it is not fully understood how and when the onset of circulation affects HSC emergence. Here we show that in Ncx1−/− mouse embryos devoid of circulation the HSC l

Context. Gaia Early Data Release 3 (Gaia EDR3) gives trigonometric parallaxes for nearly 1.5 billion sources. Inspection of the EDR3 data for sources identified as quasars reveals that their parallaxes are biased, that is, they are systematically offset from the expected distribution around zero, by a few tens of microarcseconds. Aims. We attempt to map the main dependences of the parallax bias in

NTRU is a lattice-based public-key cryptosystem that has been selected as one of the Round III finalists at the NIST Post-Quantum Cryptography Standardization. Compressing the key sizes to increase efficiency has been a long-standing open question for lattice-based cryptosystems. In this paper we provide a solution to three seemingly opposite demands for NTRU cryptosystem: compress the key size, i

Användningen av artificiell intelligens (AI), det vill säga en rad primärt databeroende metoder och teknologier för bland annat prediktion och automation, tycks bidra till en omvälvande period i den offentliga förvaltningen. Detta skifte föranleder ett styrningsbehov, ofta kopplat till tillitsfrågor, vilket i en internationell kontext inte minst syns i en stor mängd etiska riktlinjer och principie

Cloud drop condensation nuclei (CCN) and ice nuclei (IN) particles determine to a large extent cloud microstructure and, consequently, cloud albedo and the dynamic response of clouds to aerosol-induced changes to precipitation. This can modify the reflected solar radiation and the thermal radiation emitted to space. Measurements of tropospheric CCN and IN over large areas have not been possible an

EUROPRISE is a Network of Excellence sponsored from 2007 to 2011 by the European Commission within the 6th Framework Program. The Network encompasses a wide portfolio of activities ranging from an integrated research program in the field of HIV vaccines and microbicides to training, dissemination and advocacy. The research program covers the whole pipeline of vaccine and microbicide development fr

Objectives: To develop European League Against Rheumatism (EULAR) recommendations for the management of large vessel vasculitis. Methods: An expert group (10 rheumatologists, 3 nephrologists, 2 immunolgists, 2 internists representing 8 European countries and the USA, a clinical epidemiologist and a representative from a drug regulatory agency) identified 10 topics for a systematic literature searc

Understanding the interplay between human brain structure and function is crucial to discern neural dynamics. This study explores the relation between brain structure and macroscale functional activity using subject-specific structural connectome eigenmodes, complementing prior work that focused on group-level models and geometry. Leveraging data from the Human Connectome Project, we assess accura

Utsagor från vittnen är ett väsentligt inslag i en effektiv rättskipning. Hot och våld mot vittnen utgör därför ett stort hinder i det brottsbekämpande ar-betet. Om det allmänna inte kan erbjuda vittnen ett tillräckligt skydd vid så-dana angrepp, finns det risk att vittnen väljer att inte samarbeta med polisen, vilket i sin tur kan få till följd att grova brott förblir ouppklarade. I denna studie Statements by witnesses are an essential element of the efficient administra-tion of justice. The occurrence of serious forms of threats and violence to-wards witnesses and their relatives therefore constitutes a major impediment to the work in combating crime. If the public cannot offer witnesses suffi-cient protection from attacks, there is a risk that they will choose not to co-operate with the

Med hjälp av koncernbidrag, vilket kan ges mellan koncernbolag, uppnår svenska företagsgrupper en utjämning av sina resultat. Att ge koncernbidrag är möjligt bara mellan helägda dotterbolag. Med helägt menas i detta fall att moderbolaget måste äga dotterbolaget till mer än 90 procent. Det uppställs alltså ett så kallat ägandekrav för moderbolaget. Genom aktuell praxis, främst HFD 2021 ref. 66 har Through group contribution Swedish groups can equalize the results of their companies. Giving such contributions is only possible in fully owned groups. The parent company has to own more than 90 percent of the shares in its subsidiary. This is a so called ownership requirement for the parent company. The Swedish supreme administrative court has opened up for a possibility to avoid this ownership

Trots en sedan länge pågående debatt i doktrinen har både 1905 års köplag och dagens köplag tillämpats på företagsförvärv som sker genom en aktieöverlåtelse. Det är dock tydligt att lagstiftaren inte hade företagsförvärv eller aktieköp i åtanke när köplagen skrevs och reglerna tenderar därför att vara mindre lämpliga för aktieöverlåtelser vid företagsförvärv. I många situationer blir detta inget pDespite a long-standing debate in the doctrine, both the 1905 Swedish Sales of Goods Act and the current Swedish Sales of Goods Act have been applied to company acquisitions through share transfers. However, the legislator did not have company acquisitions or share purchases in mind when drafting the Sales of Goods Act and the set of rules therefore tends to be less suitable for share transfers in

In 2023 an operator theoretic approach to the Prime Number Theorem was introduced by Olsen. In this thesis this approach is examined and applied to give a new, operator theoretic, proof of a different version of the Prime Number Theorem and of the Prime Number Theorem for arithmetic progressions. This approach is then expanded and rearranged to focus on the approximation error in the Prime Number

This thesis project explores the significance of public spaces in shaping society, culture, and individual identity, emphasizing their role in promoting democratic values and self-realization. Public spaces, such as squares and marketplaces, serve as platforms for social interaction, economic activity, and cultural continuity. The design of these spaces reflects societal values and historical cont