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BACKGROUND: Humans differ in the metabolism of the neurotoxicant methyl mercury (MeHg). This variation may be partially due to variation in genes encoding the transcription factor Nuclear factor E2-related factor 2 (NRF2) and its negative regulator Kelch-like ECH-Associated Protein 1 (KEAP1), which regulate glutathione and related transporter and antioxidant proteins that play a role in the metabo
BackgroundThe global distribution of HIV-1 subtypes is evolving, which is reflected in the Swedish HIV cohort. The subtype HIV-1A6, which may be prone to developing resistance to cabotegravir, is the most common subtype in Ukraine.AimWe aimed to examine trends in HIV-1 subtype distribution in Sweden, with a special focus on HIV-1A6, and to describe the virology, demography and treatment of Ukraini
Background: Therapies that could further prevent the development of heart failure (HF) and other cardiovascular and metabolic events in patients with recent myocardial infarction (MI) represent a large and unmet medical need. Methods: DAPA-MI is a multicenter, parallel-group, registry-based, randomized, double-blind, placebo-controlled phase 3 trial in patients without known diabetes or establishe
In this study, we investigated the prosody of domestic cat meows produced in different contexts. Prosodic cues – i.e., variation in intonation, duration, voice quality and fundamental frequency – in humans as well as in nonhuman animals carry information about idiosyncratic traits of the signaller, including sex, age, and physical and mental state. The duration, fundamental frequency (F0) and into
CD40-targeting therapies can enhance the dendritic cell priming of tumor-specific T cells and repolarize intratumoral macrophages to alleviate the tumoral immunosuppressive environment and remodel the extracellular matrix. Mitazalimab is a potent agonistic CD40 monoclonal IgG1 antibody currently under clinical development. This study used RNA sequencing of blood samples from a subset of patients f
The technological push for hydrogen-based steel production has become a flagship project of the Swedish state for advancing its global environmental leadership and becoming the world's first fossil free welfare state. The new production process has the potential to drastically cut emissions in a heavy polluting industry. The plans also entail a drastic upscale in steel production, energy and iron
Machine Learning (ML) is a fundamental part of modern perception systems. In the last decade, the performance of computer vision using trained deep neural networks has outperformed previous approaches based on careful feature engineering. However, the opaqueness of large ML models is a substantial impediment for critical applications such as in the automotive context. As a remedy, Gradient-weighte
Introduction: Antimicrobial resistance (AMR) is a global public health threat. Worse still, there is a paucity of data from low-and middle-income countries to inform rational antibiotic use. Objective: Assess the feasibility of setting up microbiology capacity for AMR testing and estimate the cost of setting up microbiology testing capacity at rural district hospitals in Rwanda. Methods: Laborator
BackgroundA concussion is a common injury in many sports, including para sport. Aside from a more comprehensive need for concussion education, clinicians face difficulties applying concussion assessment and management guidelines to para athletes.1 At present, there is a lack of para-sport concussion research, and prior International Concussion in Sport (CIS) consensus papers have not addressed thi
Hippocampal atrophy is endemic in ‘normal aging’ but it is unclear what factors drive age-related changes in medial temporal lobe (MTL) structural measures. We investigated cross-sectional (n = 191) and longitudinal (n = 164) MTL atrophy patterns in cognitively normal older adults from ADNI-GO/2 with no to low cerebral β-amyloid and assessed whether white matter hyperintensities (WMHs) and cerebro
The role of natural marine aerosols in the global climate system remains understudied and uncertain. This is true for the emissions of natural volatile compounds over the ocean, the oxidation of said compounds and their impact on particle formation and particle growth. In this thesis, the emission, chemistry and aerosol particle processes relating to these compounds were studied using different pr
Energy conservation measures (ECMs) are often chosen for their immediate benefits, such as suitability to past/current climate conditions and rapid economic returns. However, the longevity of these ECMs poses a risk of becoming outdated or ineffective as climate change alters the very climatic parameters they were designed for. This paper provides insight into the foresight required when selecting
Microorganisms play a crucial role in various physiological processes, including metabolism, immune defense, nutrition absorption, defense against cancer, and protection against pathogen colonization. Changes in microbial communities serve as potential biomarkers for diseases, offering significant insights into disease treatment and diagnosis. However, the association between microorganisms and di
None of the global targets for protecting nature are currently met, although humanity is critically dependent on biodiversity. A significant issue is the lack of data for most biodiverse regions of the planet where the use of frugal methods for biomonitoring would be particularly important because the available funding for monitoring is insufficient, especially in low-income countries. We here dis
Objectives To investigate the prevalence of axial spondyloarthritis (axSpA) in patients with chronic back pain (CBP) of less than 2 years (2y) duration referred to the rheumatologist, the development of diagnosis over time, and patient characteristics of those developing definite (d-)axSpA over 2y. Methods We analysed the 2y data from SPondyloArthritis Caught Early, a European cohort of patients (
Background: Tourette syndrome (TS) and chronic tic disorder (CTD) may be associated with an increased risk of mortality, but specific causes of death are poorly understood. Objectives: In this matched cohort and sibling cohort study, we estimated the risk of all-cause and cause-specific mortality in individuals with TS/CTD, compared with unaffected matched individuals and unaffected full siblings.
In this Letter, we aim to address a knowledge gap in the intersection, and boundaries, between law(s) and circular policies, business models, and practices. By exploring the existing literature and real-life examples across the world, this work provokes further research towards a deeper understanding of the necessary changes in the legal paradigm to enable circular innovation and achieve more circ
The intricate relationship between climate change and the building sector is characterized by a self-reinforcing loop. Rising temperatures driven by global warming will inevitably impact heating and cooling energy, while buildings simultaneously contribute significantly to carbon emissions throughout their lifecycle, further exacerbating climate change. However, current knowledge regarding the int
Background: The carba mix is used to screen rubber chemical allergy and consists of three rubber sensitising chemicals: 1% (w/w) zinc diethyldithiocarbamate (ZDEC), 1% (w/w) zinc dibutyldithiocarbamate (ZDBC) and 1% (w/w) 1,3-diphenylguanidine (DPG), all in petrolatum. However, carba mix patch test results can be difficult to interpret, which may be linked to so-called ‘cocktail’ effects. Objectiv
Losses and damages from climate change are not just a future risk but already a present reality, and “Loss and Damage” (L&D) as a policy domain has been formalised under the United Nations Framework Convention on Climate Change (UNFCCC), alongside mitigation and adaptation. While climate services currently provide strong support for adaptation and disaster recovery, here we propose that an exp
