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Regulated transcription controls the diversity, developmental pathways and spatial organization of the hundreds of cell types that make up a mammal. Using single-molecule cDNA sequencing, we mapped transcription start sites (TSSs) and their usage in human and mouse primary cells, cell lines and tissues to produce a comprehensive overview of mammalian gene expression across the human body. We find
Survival after childhood cancer diagnosis has remarkably improved, but emerging evidence suggests that cancer-directed therapy may have adverse gastrointestinal late effects. We aimed to comprehensively assess the frequency of gastrointestinal and liver late effects among childhood cancer survivors and compare this frequency with the general population. Our population-based cohort study included a
Occupational exposure is an important, global cause of respiratory disease. Unlike many other non-communicable lung diseases, the proximal causes of many occupational lung diseases are well understood and they should be amenable to control with use of established and effective approaches. Therefore, the risks arising from exposure to silica and asbestos are well known, as are the means of their pr
The global movement of bees for agricultural pollination services can affect local pollinator populations via hybridization. When commercial bumblebees are of the same species but of different geographic origin, intraspecific hybridization may result in beneficial integration of new genetic variation, or alternatively may disrupt locally adapted gene complexes. However, neither the existence nor t
Testosterone is a hormone that plays a key role in carbohydrate, fat, and protein metabolism. Testosterone deficiency is associated with multiple comorbidities, e.g., metabolic syndrome and type 2 diabetes. Despite its importance in many metabolic pathways, the mechanisms by which it controls metabolism are not fully understood. The present study investigated the short-term metabolic changes of ph
Our relationships with others structure many aspects of our lives, especially during important moments such as choosing an education, entering the workforce, forming partnerships or starting a family. While the influence of family and parenting has been widely studied, less is known about the role of non-family connections, such as neighbours. One reason is that the data needed to study these rela
Background and objective: Prostate cancer (PC) is the second most common cancer and a leading cause of death among males. In this systematic review we evaluated cohort studies and randomized controlled trials (RCTs) on the relationship between dietary patterns and PC risk, progression, mortality, and biomarkers. Methods: A systematic search of MEDLINE, Embase, and Cochrane Central was conducted th
Introduction Breast cancer-related lymphoedema (BCRL) at the arm and/or trunk/breast is a highly feared complication following breast cancer treatment and can be objectified using the state-of-The-Art criteria based on volume, extracellular water ratio or skin thickness measurements. Although the incidence of objective BCRL is decreasing due to advances in breast cancer treatment, many patients re
Background Breast cancer patients undergoing mastectomy are not well represented in studies evaluating the omission of completion axillary lymph node dissection (cALND) due to sentinel lymph node (SLN) metastases. Methods The prospective multicentre SENOMIC cohort trial included patients with breast cancer and SLN micrometastases between October 2013 and December 2022. Completion ALND was omitted
Somatostatin, produced by pancreatic islet δ cells, is a key intra-islet paracrine factor that regulates the secretion of the glucoregulatory hormones insulin and glucagon from β cells and α cells, respectively. Here, we show that glutamate and glucagon released by α cells cooperatively activate neighbouring δ cells through AMPA and glucagon receptors, thereby enabling spatiotemporal feedback cont
INTRODUCTIONBoreal forests are crucial for mitigating global climate change by capturing and storing large amounts of atmospheric carbon dioxide. However, previously unmanaged primary boreal forests are being rapidly transformed to managed secondary forests to meet the rising global demand for materials and energy. Understanding the effects of boreal primary to managed secondary forest transformat
Herein, we contextualize, problematize, and offer some insights for moving beyond the problem of monolingual comparative normativity in (psycho) linguistic research on bilingualism. We argue that, in the vast majority of cases, juxtaposing (functional) monolinguals to bilinguals fails to offer what the comparison is supposedly intended to do: meet the standards of empirical control in line with th
Climate modeling suggests that achieving international climate goals requires a reduction in current CO2 emissions by over 90%, with any remaining emissions to be addressed through carbon dioxide removal (CDR) solutions. Sixteen CDR strategies are evaluated by integrating technical potential, environmental, social, and governance (ESG) criteria, along with sequestration permanence. This evaluation
This paper examines the development of the Artificial Intelligence (AI) meta-debate in Sweden before and after the release of ChatGPT. From the perspective of agenda-setting theory, we propose that it is an elite outside of party politics that is leading the debate – i.e. that the politicians are relatively silent when it comes to this rapid development. We also suggest that the debate has become This paper examines the development of the Artificial Intelligence (AI) meta-debate in Sweden before and after the release of ChatGPT. From the perspective of agenda-setting theory, we propose that it is an elite outside of party politics that is leading the debate – i.e. that the politicians are relatively silent when it comes to this rapid development. We also suggest that the debate has become
Background: Small airway dysfunction (SAD) is associated with impaired asthma control, but small airway physiology is not routinely assessed in clinical practice. Previously, we demonstrated impulse oscillometry (IOS)-defined small airway dysfunction (SAD) in dual responders (DRs) upon bronchoprovocation with various allergens. Aim: To compare lung physiology using spirometry and IOS following bro
MOS Variabellista inkl frekvenser - Halvtidskontroll (2018-06-13) Sida 1 av 50 Nr Name Format Variable label File Checked #B #BB Deltagare 1 lopnrMOS Numeric Löpnummer vid MOS baslinjeundersökning (Numerisk) MOS_Deltagare_halvtid.savAD 1326 1321 2 lopnrMOS_str8 String Löpnummer vid MOS baslinjeundersökning (Sträng, utan mellanstreck)MOS_Deltagare_halvtid.savAD 1326 1321 3 lopnrMOS_str9 String Löpn
DESCRIPTIVE ANALYSIS OF PERSONALITY AND DEFENSE IN DRUG ABUSERS ACCORDING TO DEFENSE MECHANISM TECHNIQUE MODIFIED (DMTm) Psychoanalytic Conceptions of the Mind in Relation to Personality Disorders of Drug Abusers Kristian Aleman Department of Psychology, Lund University The purpose was to investigate whether signs of DMTm (Defense Mechanism Technique modified) could discriminate between the ten gr
https://www.psy.lu.se/sites/psy.lu.se/files/vol7no2.pdf - 2026-06-12
Distinct Growth Phases in Early Life Associated With the Risk of Type 1 Diabetes: The TEDDY Study Distinct Growth Phases in Early Life Associated With the Risk of Type1Diabetes:TheTEDDYStudy Diabetes Care 2020;43:556–562 | https://doi.org/10.2337/dc19-1670 OBJECTIVE This study investigates two-phase growth patterns in early life and their association with development of islet autoimmunity (IA) and
https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-04/116_MP208_Liu_Diab%20Care.%20Growth%20pattern_2020.pdf - 2026-06-12
DEVRES 2024: Reaching the Sustainable Development Goals in a polarized world: Abstracts Reaching the Sustainable Development Goals in a polarized world Abstracts PARALLEL RESEARCH SESSIONS, WORLD CAFÉ AND SDG IMPACT STORIES Table of content PARALLEL RESEARCH SESSIONS ...........................................................................................................3 DATE: 22ND OCT | TIME:
https://www.lucsus.lu.se/sites/lucsus.lu.se/files/2024-10/DEVRES%202024%20-%20ABSTRACTS.pdf - 2026-06-12
