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Associations between APOE Genotypes and Disease Susceptibility, Joint Damage and Lipid Levels in Patients with Rheumatoid Arthritis

Objective: Apolipoprotein E (APOE) genotypes are associated with cardiovascular disease (CVD) and lipid levels. In rheumatoid arthritis (RA), an association has been found with disease activity. We examined the associations between APOE genotypes and disease susceptibility and markers of disease severity in RA, including radiographic joint damage, inflammatory markers, lipid levels and cardiovascu

Ställningsfullmakt utifrån ett rättssäkerhetsperspektiv

10 § 2 st. AvtL reglerar den s.k. ställningsfullmakten. Enligt bestämmelsen kan en fullmäktig som intar en viss ställning rättshandla i en huvudmans namn. Gränserna för fullmäktigens behörighet avgörs genom den behörighet som enligt lag eller sedvänja följer av den ställning fullmäktigen intar. I praktiken har bestämmelsen om sedvänja störst betydelse, då det finns förhållandevis få antal ställnin

Anställdas yttrandefrihet och kritikrätt. En komparativ studie av rättsläget rörande whistleblowing i Sverige, Norge och England

Uppsatsen har två huvudsakliga syften. Dels att utreda rättsläget rörande anställdas yttrandefrihet och kritikrätt på svensk och europeisk nivå, dels att undersöka vilket skydd svensk rätt ger anställda som avslöjar missförhållanden på arbetsplatsen, s.k. whistleblowing. Bedömningen av det senare sker mot bakgrund av den särskilda whistleblowinglagstiftningen i Norge och England. I svensk rätt äThe thesis has two main purposes. The first one aims at establishing the current legal situation for employees’ freedom of expression and right to criticize the organization in which they work. This is done on a national level as well as on a European level. The second purpose is to investigate the level of protection that Swedish law provides for so called whistleblowers; employees who reveal pos

The freedom of establishment and German corporation tax - an analysis of the Saint-Gobain judgement

Non-harmonized direct taxes fall within the Member States' competence. This means that the Member States are free to develop their own tax systems, as long as there is no Community harmonisation. But since the freedom of establishment (and other rights under the EC Treaty) could be disturbed by national tax law, this competence must be exercised in consistency with Community law to avoid any d

Personlig integritet i arbetslivet - Den nya teknikens ökade möjligheter till kontroll av anställda

Detta är en uppsats om personlig integritet i arbetslivet. Många arbetsgivare känner ett behov av att kontrollera sina anställda, men i vissa fall kan dessa kontroller innebära en kränkning av arbetstagarens integritet. Kontrollmöjligheterna har ökat i och med den tekniska utvecklingen men frågan är om skyddet för den enskilde arbetstagarens personliga integritet ökat i samma takt. Jag har i denna

Beslutanderätt vid gemensam vårdnad - fördelning av föräldraansvar och tvistlösning i ett komparativt perspektiv

I princip alla beslut som rör barnets angelägenheter vid gemensam vårdnad ska fattas gemensamt av föräldrarna. Konsensuskravets omfattning kan dock ge upphov till en statisk relation mellan föräldrarna där barnets intresse inte tillgodoses på grund av föräldrarnas oenighet. En utredning har tillsatts för att undersöka vilka nackdelar som kan uppkomma för barnet när föräldrarna inte når konsensus i

Tvistemålens rättegång i hovrätt - onödig repris eller nödvändig omprövning?

I Västeuropa har ett omdiskuterat ämne länge varit hur tillgången och prövningen till den andra instansen skall se ut. Problemet med måltillströmningen i domstolarna i många länder är inte nytt och frågan på vilket sätt tillgången till den andra instansen kan begränsas är inte ovanlig. I Sverige är för närvarande frågan om hovrättens funktion och prövning viktig då det råder ett missnöje med hur h

The Classified Information Procedures Act:(CIPA) and Suspected Terrorists in Federal Civilian Courts: Subject to the Most Exacting Demands of Justice?

The condemnation of the specialized procedures of the faulty military commission system, particularly ex parte and in camera hearings to determine the closure of confidential information, has resulted in the contention that terror cases may be properly adjudicated in regularly constituted Article III courts. Proponents of prosecution of terror suspects in federal civilian courts assert that the co

En studie av skadeståndssanktionen vid varumärkesintrång

This paper discusses the sanction for damages upon trademark infringement. The Swedish trademark law, 38 §, is compared to the coming proposal of the Swedish trademark law, 67 §. The final law proposal is yet to be determined; the proposal has not been published in Swedish code of statutes and is therefore not in effect. A central issue is whether the new proposal will improve the, thus far, medio

Models of Scholarly Communication and Citation Analysis

Informetric/bibliometric analyses have to a large extent been relying on an assumption that research is essentially cumulative in its nature, which is not the least visible in the rational for using citation analyses to assess quality of research. However, when reviewing both the theoretical literature on how research is organized and studies analyzing the structures of research fields through inf

Implementation of Formalin-Fixed, Paraffin-Embedded Cell Line Pellets as High-Quality Process Controls in Quality Assessment Programs for KRAS Mutation Analysis

In recent years, the mutational status of the KRAS oncogene has become incorporated into standard medical care as a predictive marker for therapeutic decisions related to patients with metastasized colorectal cancer. This is necessary, because these patients benefit from epidermal growth factor receptor (EGFR)-targeted therapy with increased progression-free survival only if the tumor does not car

Neutronic analysis of the bi-spectral moderator such as that proposed for ESS

This paper reports on design studies concerning a moderator concept which aims to maximize the time averaged flux. The idea is to provide neutron spectra showing two clear maxima, with peaks at (similar to 1 angstrom) and (similar to 2.5 angstrom) arising from leakage from both cryogenic and thermal moderators. Such a concept known as a bi-spectral moderator (Mezei, 2006 [1]) while proven on a rea

Neonatal resuscitation - studies in piglets

Background and aims: “It’s best to start with air” states the current guidelines on the resuscitation of babies at birth. In a piglet model mimicking severe neonatal asphyxia and circulatory arrest, different aspects of resuscitation were investigated (studies I-III). The hypotheses were that the return of spontaneous circulation (ROSC) would occur faster with the use of oxygen (I and III) or adre

Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials.

Many patients with asthma or chronic obstructive pulmonary disease (COPD) routinely receive a combination of an inhaled bronchodilator and anti-inflammatory glucocorticosteroid, but those with severe disease often respond poorly to these classes of drug. We assessed the efficacy and safety of a novel inhaled dual phosphodiesterase 3 (PDE3) and PDE4 inhibitor, RPL554 for its ability to act as a bro

On the Reliability of Mapping Studies in Software Engineering

Background: Systematic literature reviews and systematic mapping studies are becoming increasingly common in software engineering, and hence it becomes even more important to better understand the reliability of such studies. Objective: This paper presents a study of two systematic mapping studies to evaluate the reliability of mapping studies and point out some challenges related to this type of