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Death of a Genre? The Aesopic Fable in Confrontation with Modernity

Scholars of European fable history over and over again have returned to the question of a possible death of the Aesopic genre. Arguments have been brought forward in accordance with mainly two opposing views. On the one hand, it has been claimed that the fable genre towards the end of the eighteenth century reached a stage of crisis and, more or less, perished. On the other hand, it has been asser

U-Pb baddeleyite geochronology of Precambrian mafic dyke swarms and complexes in southern Africa - regional scale extensional events and the origin of the Bushveld Complex

Popular Abstract in Swedish Diabasgångar (eng. dolerite dykes) bildas när järn- och magnesiumrika (mafiska) smältor från manteln transporteras upp genom jordskorpan och så småningom kyls av och kristalliserar i sprickor på djupet. Gångarna kan bli hundratals meter breda och kan uppträda i stort antal och bilda s.k. gångsvärmar vilka är uttryck för perioder då jordskorpan har utsatts för extensioneDolerite dykes are formed when iron- and magnesium-rich (mafic) mantle-derived magmas ascend through the lithosphere (upper part of the mantle) and crystallize as ‘hydro-fractures’ within the crust. Dykes may exist in great numbers to form dyke swarms (linear or radiating), which can be linked to time periods of continental break-up, or attempted break-up events, associated with voluminous volcani

Role of Wnt-5a in breast cancer

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen hos västerländska kvinnor. I Sverige kommer var tionde kvinna att drabbas av bröstcancer, vilket motsvarar drygt 5000 kvinnor om året. Dödligheten i bröstcancer är 30%. Detta innebär att en tredjedel av de som drabbas kommer att dö av sin sjukdom. Det är dock inte själva tumören i bröstet som dödar eftersom denna i princip alltBreast cancer is one of the most common cancer forms in the industrialized world. Only in Sweden, nearly 6000 women are diagnosed with breast cancer each year and 1/3 of them eventually succumb to the disease. Wnts are a family of genes that have been implicated in many human tumours, so far mainly studied in colorectal cancer where activated Wnt signalling occurs in a vast majority of tumours. Wh

The transitional landscape of urbanity - territorial and visual challenges in the urban periphery of Malmö

The greater cities’ outer transitional zones are ephemeral and dynamic. With Malmö (Sweden) as an example this paper discusses how coastal and agricultural landscapes in the urban fringe can develop into something new and closer to actual needs of the inhabitants. This is done by opening up for a use of new concepts when describing these areas, for example among planners/designers and exploiters.

Impact of Left Ventricular Morphology on Adverse Outcomes Following Stage 1 Palliation for Hypoplastic Left Heart Syndrome : 20 Years of National Data From Sweden

BackgroundHypoplastic left heart syndrome is associated with significant morbidity and mortality. We aimed to assess the influence of left ventricular morphology and choice of shunt on adverse outcome in patients with hypoplastic left heart syndrome and stage 1 palliation.Methods and ResultsThis was a retrospective analysis of patients with hypoplastic left heart syndrome with stage 1 palliation b

Conventional and novel anti-seizure medications reveal a particular role for GABAA in a North Sea progressive myoclonus Epilepsy Drosophila model

Objective: North Sea Progressive Myoclonus Epilepsy (NS-PME) is a rare genetic disorder characterized by ataxia, myoclonus and seizures with a progressive course. Although the cause of NS-PME is known, namely a homozygous mutation in the GOSR2 gene (c.430 G>T; p. Gly144Trp), sufficient treatment is lacking. Despite combinations of on average 3–5 anti-seizure medications (ASMs), debilitating myoclo

Facing and dealing with emotional turbulence : Living with newly diagnosed Parkinson's disease

Introduction: The experiences of living with Parkinson's disease (PD) from the perspective of newly diagnosed persons with PD (PwPD) have not been previously described. Aim: This study aimed to gain a better understanding of the impact of living with the early stages of PD. Methods: A qualitative interview study was conducted among nine persons, seven men and two women, from southern Sweden. Parti

Grain boundary strain localization in a CdTe solar cell revealed by scanning 3D X-ray diffraction microscopy

Cadmium telluride (CdTe) solar cell technology is a promising candidate to help boost green energy production. However, impurities and structural defects are major barriers to improving the solar power conversion efficiency. Grain boundaries often act as aggregation sites for impurities, resulting in strain localization in areas of high diffusion. In this study, we demonstrate the use of scanning

Phosphodiesterase 5 and its inhibitors with ischemic heart disease : a Mendelian randomization analysis and a real-world study

BACKGROUND: Accumulating studies reported that several phosphodiesterases (PDEs) inhibitors might have cardiovascular benefits.OBJECTIVES: This study aimed to explore the relationship between genetically-predicted PDEs and ischemia heart disease via drug target Mendelian randomization (MR) approach, and then examine the effect of inhibitors of identified target on the outcomes by using real-world

Hormone receptor mRNA and protein levels as predictors of premenopausal tamoxifen benefit

Background and purpose: Tamoxifen remains an important adjuvant treatment in premenopausal patients with hormone receptor-positive breast cancer. Thus, determination of hormone receptors is important. Here, we compare cytosol-based methods, immunohistochemistry (IHC), and gene expression (GEX) analysis for determining hormone receptor status in premenopausal breast cancer patients from a randomise

Health-related quality of life by type of breast surgery in women with primary breast cancer : prospective longitudinal cohort study

Background: Health-related quality of life and patient-related outcome measures for patients with cancer have gained increased interest over the last decade. However, few prospective studies with longitudinal data evaluated health-related quality of life in patients with breast cancer. This study aimed to investigate how health-related quality of life changed from the time of diagnosis to 1 year a

The natural menstrual cycle revisited – can natural cycle be trusted

Background: The serum progesterone (P4) level during the luteal phase (LP) plays a crucial role in the initiation and maintenance of pregnancy. However, it is unclear whether the natural cycle consistently provides the best endocrine profile and whether mid-luteal serum P4 levels are always sufficient to support implantation and early pregnancy. The question has become more relevant in relation to

High one-year mortality following intensive care among adults with influenza A(H1N1)pdm09, A(H3N2), or B in Southern Sweden : a retrospective observational study

Background: Influenza ranges from a mild and self-limiting infection to a life-threatening disease with high mortality despite intensive care. Conclusive data on the association between influenza type/subtype and mortality among adults treated at intensive care units (ICU) is lacking. Objectives: To investigate the mortality in adults admitted to ICU with laboratory-confirmed influenza during thre

A High Rate of Acute Injuries in Para Alpine Skiing—A Combined Prospective Study of Injuries Reported at the Sochi 2014, PyeongChang 2018, and Beijing 2022 Paralympic Winter Games

Para Alpine skiing is one of the largest sports at the Paralympic Winter Games. Recent studies report high injury rates in this sport. However, limited evidence exists regarding sport-specific injury characteristics, which is essential for targeted prevention. The aim of this study was to describe the overall incidence proportion and incidence of injuries reported by athletes participating in Alpi

Exposome project for health and occupational research night shift cohort (EPHOR-NIGHT) : a unique resource to advance research on night shift work and chronic disease

Purpose The EPHOR-NIGHT cohort was established to investigate how night shift work influences biological pathways and chronic disease risk using a comprehensive working-life exposome approach, focusing on cardiometabolic, mental health, cognitive and biological ageing outcomes. Participant The cohort includes 937 workers aged 20–65 years (88%female), primarily from the healthcare sector (96%) in S