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Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fracture applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch individuals aged >55 years; and comprising 329 cases and 2666 controls with radiographic

Background The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain. Methods We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in

Epigenetic variation may contribute to the development of complex metabolic diseases such as type 2 diabetes (T2D). Hepatic insulin resistance is a hallmark of T2D. However, it remains unknown if epigenetic alterations take place in the liver from diabetic subjects. Therefore, we investigated the genome-wide DNA methylation pattern in the liver from subjects with T2D and non-diabetic controls and

Hypoxia hampers eutrophication reduction efforts by enabling high nutrient fluxes from sediment to bottom waters. Oxygenation of hypoxic water bodies is often proposed to reduce benthic ammonium and phosphate release. This study investigates the functional response of benthic nitrate-reducing processes to a long-term engineered oxygenation effort in a density-stratified fjord with euxinic bottom w

The paper is a sounding of Ulrich Beck's and Edgar Grande's conceptual map of the varieties of second modernity - Western and Non-Western, European and beyond - that makes up today's world. Their mapping is examined in the light of two, striking analytical perspectives associated with Ulrich Beck: everyday 'cosmopolitization' and his call for a methodological cosmopolitanism. A line of inquiry exp

The popliteal artery (PA) is, after aorta, the most common site for aneurysm formation. Why the PA is more susceptible than other peripheral muscular arteries is unknown. We hypothesized that the wall composition, which in turn affects wall properties, as well as the circumferential wall stress (WS) imposed on the arterial wall, might differ compared to other muscular arteries. The aim was to stud

. The aim of this article is to provide an up-to-date overview on paediatric haemophilia care in the world, with emphasis on medical treatment, rehabilitation, and orthopaedic surgery. The reason these specific professions caregivers are included is that over 90% of bleeding episodes in people with haemophilia (PWH) occur within the musculoskeletal system; and of these 80% of bleedings occur in jo

The aim of this study was to estimate the prevalence of frequent knee pain in radiographic, symptomatic and clinically defined knee OA in middle-aged and elderly patients and the proportion that seeks medical care.

The influence of temperature, salts, pH, and various pre-treatments and cleaning on the nanofiltration (NF) performance of thin-film polyamide (PA) composite membranes has been investigated. The change in membrane performance was correlated to membrane swelling or/and electroviscous friction. Aspects of costs and energy demand while using NF at elevated temperatures were also evaluated. The increa

Commodity currencies have been stood against fiat money in the discourses on the history of money, implying a development from primitive forms of money – which needed anchor in a real commodity to gain acceptance, for instance gold, silver or copper – to a more sophisticated monetary regime based solely on confidence and trust. This paper argues that the idea of a gradual replacement of the former

In 2019 the first neutrons will be fired at the ESS plant, at least to its present plan, located in the outskirts of Lund, the brightest neutron facility in the world. In the scientists’ self-images, this kind of high technology and international cooperative knowledge production is entitled Big Science or Global Science. The concept “technoscience” isn’t used. This chapter will discuss if the conc

The purpose of this study is to elucidate affordances and meaning-making processes where students in Compulsory lower secondary education learn to play music together in music class. The data consists of a series of observed music lessons, performances and stimulated recall interviews in two 8th form classes, video recorded in the course of one term. The analysis focuses on students’ and their tea

Popular Abstract in Swedish Arbetet i denna avhandling presenteras i 6 olika delarbeten (artiklar I-VI). Artiklarna I-III behandlar två olika enzymer som bryter ner cyklodextriner, vilka är ringformade molekyler med samma beståndsdelar som i stärkelse (dvs sammanlänkade glukosmolekyler). Dessa s.k. cyklodextrinaser kommer ursprungligen från två bakterier som har isolerats i varma källor på Island.

Uppsatsen försöker att ta ett samlat rättssociologiskt grepp om kränkningsersättningen som är den viktigaste formen av brottsskadeersättning (under år 2006 betalade Brottsoffermyndighe-ten ut över 81 miljoner konor i kränkningsersättning). Hur dessa skador värderas och konstrueras speglar samhällets rättskultur och ger upphov till en rad rättssociologiska frågeställningar om rättens roll och samsp

Den här uppsatsen skall undersöka några av företeelserna som har betydelse för ett skapande av en europeisk identitet och ett "gemensamt" Europa. Diskussionen om Europa som gemensam institution handlar oftast om ekonomiska svårigheter, sällan diskuteras t.ex. historiska, normativa, och kulturella mellanmänskliga och mellanstatliga dilemman i större sammanhang. Frågan jag ställer i uppsatsen tar ju

Popular Abstract in Swedish Avhandlingen är en studie av hur stöd och service organiseras kring fyra barn med funktionshinder och deras familjer. I denna service är normalt flera olika formella organisationer involverade, som barnhabilitering, förskola/skola/särskola, hjälpmedelscentral, assistentorganisationer, sjukvård m fl. Dessutom kan barnets och familjens situation vara komplicerad på många This study explores the organising of services for disabled children and their families in Sweden. It is based on 83 interviews with parents and involved staff surrounding four disabled children, with both physical and intellectual disabilities, and between two and nine years old. Further, 15 meetings between parents and staff were observed, primarily serving as background material. The service pr

Popular Abstract in Swedish Hos människan lever en rad mikroorganismer som tillsammans utgör normalfloran. Normalfloran återfinns på alla kroppsytor, det vill säga huden och slemhinnorna i munnen, svalget, magsäcken, tunn- och tjocktarmen, vagina och urinrörsmynningen. Samspelet mellan människokroppen och mikroorganismerna utsätts dagligen för påfrestningar. En sådan naturlig påfrestning är de sjuThis thesis is concerned with a family of bacterial surface proteins expressed by different strains of the anaerobic Gram-positive, commensal and human pathogen Peptostreptococcus magnus. These proteins have been studied with respect to their role in virulence, function, structure, and evolution. Strains isolated from patients with vaginosis have previously been shown to be associated with express

This chapter introduces basic differences between Free/Open Source Enterprise Resources Planning systems (FOS-ERP) and Proprietary ERP (P-ERP), revisiting the previous work of Carvalho (2008). Taking into account that some years has passed and the economic downturn came, it updates key aspects of FOS-ERP under both vendor and adopter perspectives. Like its predecessor, this chapter contributes to