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Anaerobic bacteria dominate the human normal microbiota but strikingly little is known about these commensals. Finegoldia magna is a Gram-positive anaerobe found in the skin and at other non-sterile body surfaces, but it is also an opportunistic pathogen. This study describes a novel protein designated FAF (F. magnaAdhesion Factor) and expressed by more than ninety percent of F. magna isolates. Th

BACKGROUND: To elucidate the mechanism by which local delivery of 3-morpholino-sydnonimine (SIN-1) affects intimal hyperplasia after percutaneous transluminal coronary angioplasty (PTCA). METHODS: Porcine coronary arteries were treated with PTCA and immediately afterwards locally treated for 5 minutes, with a selective cytosolic guanylate cyclase inhibitor, 1 H-(1,2,4)oxadiazole(4,3-alpha)quinox

We consider the log-likelihood function of hidden Markov models, its derivatives and expectations of these (such as different information functions). We give explicit expressions for these functions and bound them as the size of the chain increases. We apply our bounds to obtain partial second order asymptotics and some qualitative properties of a special model as well as to extend some results

This article extends the common correlated effects pooled (CCEP) estimator to homogenous dynamic panels. In this setting, CCEP suffers from a large bias when the time span (T) of the dataset is fixed. We develop a bias-corrected CCEP estimator that is consistent as the number of cross-sectional units (N) tends to infinity, for T fixed or growing large, provided that the specification is augmented

Despite many reports of putative stem-cell-based treatments in genetic and degenerative disorders or severe injuries, the number of proven stem cell therapies has remained small. In this Review, we survey advances in stem cell research and describe the cell types that are currently being used in the clinic or are close to clinical trials. Finally, we analyse the scientific rationale, experimental

Enzymatic transglycosylation of lactose into oligosaccharides was studied using wild-type β-glucosidase (CelB) and active site mutants thereof (M424K, F426Y, M424K/F426Y) and wild-type β-mannosidase (BmnA) of the hyperthermophilic Pyrococcus furiosus. The effects of the mutations on kinetics, enzyme activity, and substrate specificity were determined. The oligosaccharide synthesis was carried out

BACKGROUND: Clinical Record (CR) writing is a fundamental skill for healthcare professionals, but the best e-learning methods for teaching it remain unstudied. Therefore, we investigated speech therapy students' differences in the quality production of CR at the placement and their experience after following asynchronous or synchronous e-learning courses.METHODS: A multi-method randomised controll

We consider a version of the Erdős–Rothschild problem for families of graph patterns. For any fixed k≥3, let r0(k) be the largest integer such that the following holds for all 2≤r≤r0(k) and all sufficiently large n: The Turán graph Tk−1(n) is the unique n-vertex graph G with the maximum number of r-edge-colorings such that the edge set of any copy of Kk in G is rainbow. We use the regularity lemma

Despite the increased use of different types of gender-fair forms in French, studies investigating their interpretation in context remain few. To fill this gap, we conducted a pre-registered study using a timed sentence evaluation task to examine speakers' possibilities to establish an anaphoric relationship between a gendered anaphoric expression (women or men) and non-stereotyped role nouns as a

We demonstrate for the first time that seeded harmonic generation on electron storage rings can produce coherent optical pulses in the vacuum ultraviolet spectral range. The experiment is performed at Elettra, where coherent pulses are generated at 132nm, with a duration of about 100fs. The light source has a repetition rate of 1kHz and adjustable polarization; it is very bright, with a peak power

Molecular docking is a computational approach that predicts interactions between ligands and protein targets based on binding energies. In this study, the potential interactions of 1,8-cineole -one of the dominant components of Eucalyptus globulus oil- with the main protease (Mpro) and macrodomain (MacI) of SARS-CoV-2 were studied by molecular docking. Nine Mpro and four ManI structures available

Over the last decades, linguistic gender-fair forms have become increasingly used by individuals and official institutions. In the French-speaking sphere, this has led to heated discussions among politicians and other stakeholders, some of which claim that these forms render texts illegible and inaccessible to the greater public. However, the processing of gender-fair forms in reading has been the

Amelogenin, the most abundant protein in developing enamel, self-assembles into supramolecular structures that serve as templates for apatite growth. Recent studies revealed that amelogenin nanoribbons exhibit hallmark features of functional amyloids, yet the molecular mechanisms governing their formation remain incompletely understood. Here, we combine atomic force microscopy, transmission electr

The precursors, [ 35S]sulfate and [2- 3H]mannose, were used to study the biosynthesis of keratan sulfate and other oligosaccharides on proteoglycans isolated from Day 8 cultures of chick limb bud chondrocytes. After alkaline borohydride treatment, three fractions with sialic acid were separated by molecular sieve chromatography. The first contained keratan sulfate which was purified by digestion w

This paper presents a symbol time offset estimator for coherent OFDM systems. This estimator exploits both the redundancy in the cyclic prefix and the pilot symbols used for channel estimation. The estimator is robust against frequency offsets and is suitable for use in dispersive channels. We base the estimator on the ML estimator for the AWGN channel. Simulations of an example system indicate a

In the beam dynamics design and modelling of the Eu- ropean Spallation Source (ESS) Drift Tube Linac (DTL) simplified models have been used for the focusing and ac- celerating elements. Since the high current requires precise control of the beam to analyze the losses it is useful to per- form the beam dynamics simulations by using accurate field maps of the focusing and accelerating elements. In t