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Management of postmenopausal bleeding in Sweden: a need for increased use of hydrosonography and hysteroscopy.

Background. The objective was to determine how postmenopausal bleeding (PMB) is managed in Sweden today, and to relate the findings to a new evidence-based algorithm for the management of PMB. Methods. A questionnaire regarding the role of ultrasound and the use of different endometrial biopsy methods in the management of PMB was sent to all 61 gynecologic departments in Sweden. Results. Fifty-n

Do spermathecal morphology and inter-mating interval influence paternity in the polyandrous beetle Tribolium castaneum?

In polyandrous insects, postcopulatory sexual selection is a pervasive evolutionary force favouring male and female traits that allow control of offspring paternity. Males may influence paternity through adaptations for sperm competition, and females through adaptations facilitating cryptic female choice. Yet, the mechanisms are often complex, involving behaviour, physiology or morphology, and the

Enhancement of anaerobic batch digestion of sisal pulp waste by mesophilic aerobic pre-treatment

Pre-treatment of sisal pulp prior to its anaerobic digestion was investigated using an activated sludge mixed culture under aerobic conditions in batch bioreactors at 37 degrees C. The progression of aerobic pre-treatment of the residue in relation to the activities of some extracellular hydrolytic enzymes in the slurry was monitored. The highest activity of hydrolytic enzymes was obtained at 9 h

Effects of phasic and tonic activation on contraction dynamics in smooth muscle

Responses to isotonic quick releases of rabbit urinary bladder strips and rat portal veins activated by AC-stimulation and K+-high medium were studied. The AC stimulation was adjusted to give the same tension as th K+-contractures. Releases were performed at peak of the contractions (which was attained after 1.5-4.5 s AC-stimulation or 2-3 min in K+-high solution). The length response consisted of

Phase equilibria of the mixed didodecyldimethylammonium bromide-sodium taurodeoxycholate-water system with a large solution region

The phase behavior over the entire concentration range for the system didodecyldimethylammonium bromide (DDAB)-sodium taurodeoxycholate (STDC)-water, at 25 degrees C, has been investigated, with emphasis on the DDAB-rich part. Polarizing microscopy, SAXS, H-2 NMR and H-1 self-diffusion NMR have been used in combination as probing techniques for phase behavior and microstructure. The system forms f

Inflammation-sensitive plasma proteins are associated with increased incidence of heart failure: A population-based cohort study.

BACKGROUND: Although inflammation has been associated with different cardiovascular diseases, the relationships with future heart failure (HF) are unclear. This population-based study explored whether elevated plasma levels of inflammatory proteins are associated with incidence of HF. METHODS: Five inflammation-sensitive plasma proteins (ISPs, fibrinogen, ceruloplasmin, haptoglobin, orosomucoid, a

A Pharmacokinetic and Dosing Study of Intravenous Insulin-Like Growth Factor-I and IGF-Binding Protein-3 Complex to Preterm Infants.

In preterm infants, low levels of Insulin like growth factor 1 (IGF-I) have been associated with impaired growth and retinopathy of prematurity. Our objective was to study safety and pharmacokinetics of intravenously administered rhIGF-I with its binding protein 3 (rhIGFBP-3) to preterm infants. At 3 days chronological age, an intravenous 3 hours infusion of rhIGF-I/rhIGFBP-3 was administered foll

Design, synthesis and evaluation of spiro-bicyclo[2.2.2]octane derivatives as paclitaxel mimetics

Nature contains an endless supply of natural products and has for long been a source of inspiration for the pharmaceutical industry. Many of the drugs currently in clinical use originate from natural products. Paclitaxel, the active substance in the anti cancer medicine Taxol, was first isolated from the Pacific yew tree (Taxus brevifolia) in the early 1960s during a screening program for novel an

The mucosa-associated bacteria from the sigmoid colon of nine healthy 60 years old individuals, identified by bacterial 16S rDNA

The bacterial flora of the gastro intestinal (GI) tract may be involved in chronic inflammation and colon cancer and affected by antibiotics, cytotoxic drugs and radiotherapy, trauma and intensive care therapy. It is important to map the mucosa-associated flora in healthy individuals to clarify the pathogenic risk under stressed conditions. The aim was to achieve an overview of the mucosa-associat

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Abstract in Undetermined Att skriva kandidatuppsats innebär en stor och spännande utmaning för de flesta studenter. Det är under arbetet med denna som man förväntas ta det sista steget till att bli en självständig kunskapsproducent och belönas med en filosofie kan- didatexamen. Därmed framstår den såväl som det mest krävande som lärorika momentet på grundutbildningen. I den här boken görs en grun

Increased Risks of Coronary Heart Disease and Stroke Among Spousal Caregivers of Cancer Patients.

BACKGROUND: Spousal caregivers of cancer patients suffer psychological and physical burdens, which may affect their risk of subsequently developing coronary heart disease (CHD) and stroke. METHODS AND RESULTS: Cancer patients were identified in the Swedish Cancer Registry, and information on their spouses was retrieved from the Swedish Multi-Generation Register. Follow-up of caregivers was carri

The effect of increased experience on complications in robotic hysterectomy for malignant and benign gynecological disease.

The study objective was to assess the effect of increased experience on complications in robotic hysterectomy for malignant and benign gynecological disease. This is a retrospective cohort study. It is a Canadian Task Force classification II-2 study conducted at the University Hospital, Sweden. The patients were 949 women planned for robotic hysterectomy for malignant (75 %) and benign (25 %) gyne

Patellofemoral osteoarthritis coexistent with tibiofemoral osteoarthritis in a meniscectomy population.

Objectives: To evaluate the frequency of patellofemoral osteoarthritis and its relevance to symptoms and function in a meniscectomy population. Methods: 317 patients with no cruciate ligament injury were evaluated (mean (SD) age, 54 (11) years). They had undergone meniscal resection 15 to 22 years earlier (follow up rate 70%). Standing tibiofemoral and skyline patellofemoral radiographs were grade

Interactions of N2O5 and Related Nitrogen Oxides with Ice Surfaces: Desorption Kinetics and Collision Dynamics

The detailed interactions of nitrogen oxides with ice are of fundamental interest and relevance for chemistry in cold regions of the atmosphere. Here, the interactions of NO, NO2, N2O4, and N2O5 with ice surfaces at temperatures between 93 and 180 K are investigated with molecular beam techniques. Surface collisions are observed to result in efficient transfer of kinetic energy and trapping of mol

Injuries in STS travel – a multi methodology approach to estimate incidence and societal costs

Objective: Previous research has shown that elderly and disabled travelers using Special Transportation Services (STS) are injured without being involved in a vehicle crash. In order to estimate the true costs for these vehicle-related injuries, the focus needs to be adjusted towards an incident/traveler-oriented perspective. The aim of the project was thus to utilize such a perspective, in order

Time delay between symptom and surgery in patients with carotid artery stenosis.

Andgren S, Sjöberg L, Norrving B, Lindgren A. Time delay between symptom and surgery in patients with carotid artery stenosis. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2010.01478.x. © 2011 John Wiley & Sons A/S. Objectives - Many severe strokes are preceded by warning signs such as a transient ischemic attack or stroke with minor deficits. Carotid endarterectomy (CEA) of a symptomatic carot

The prevalence of atrial fibrillation in a geographically well-defined population in Northern Sweden: implications for anticoagulation prophylaxis.

Objectives: The aims of this study were to evaluate the community-based prevalence of atrial fibrillation (AF) in a western society using a geographically well-defined population in the northern part of Sweden as a reference and to estimate the proportion of patients eligible for oral anticoagulation (OAC) prophylactic therapy according to the stroke risk indices CHADS(2) and CHA(2) DS(2) -VASc. B

Finite codimensional invariant subspaces in Hilbert spaces of analytic functions

Let $\scr H$ denote a Hilbert space consisting of functions analytic on a bounded, open, connected subset $\Omega$ of the complex plane. Given certain natural hypotheses on $\scr H$, the author characterizes the finite-codimensional subspaces of $\scr H$ that are invariant under multiplication by $z$, showing that all such subspaces have the form $(p\scr H)^-$, where $p$ is a polynomial whose zero

Laparoscopic extended pelvic lymphadenectomy for staging can be performed with limited morbidity and short hospital stay in patients with prostate cancer.

Objective: Assessing lymph-node status in prostate cancer patients with high accuracy is only possible with surgical staging, despite the evolution of modern imaging techniques. The use of surgical staging has to be balanced against the complications of the procedure, the individual patient's risk for harbouring metastasesand the consequences for the treatment of the patient if such metastases are