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The incidence of trisomy 8 as a sole chromosomal aberration in myeloid malignancies varies in relation to gender, age, prior iatrogenic genotoxic exposure, and morphology

Although trisomy 8 as a sole change is one of the most common chromosomal abnormalities in myeloid malignancies, it is largely unknown if the incidence of this aberration is influenced by other factors of clinical importance. In the present study, the frequencies of isolated +8 in relation to gender, age, previous treatment with chemo- or radiotherapy, and morphologic subtype were ascertained in p

Urban driving patterns - characterisation, variability and environmental implications.

Popular Abstract in Swedish Fordons körmönster, dvs deras hastighets- och accelerationsprofiler, påverkar avgasutsläpp och bränsleförbrukning avsevärt. Detta projekt syftade till att undersöka körmönster i tätort genom att behandla följande delområden: 1) Hur kan körmönster mätas?, 2) Hur kan körmönster beskrivas? – dvs att finna mått för att karakterisera olika egenskaper hos körmönster., 3) Vad Driving patterns, i.e. the speed and acceleration profiles of vehicles affect exhaust emission and fuel consumption considerably. This project was aimed at investigating urban driving patterns by focusing on the following issues: 1) how to measure driving patterns, 2) measures for the description of driving patterns, 3) identification of characteristics of driving patterns that have significant ef

Cloning and sequencing of the Bet v 1-homologous allergen Fra a 1 in strawberry (Fragaria ananassa) shows the presence of an intron and little variability in amino acid sequence

The Fra a I allergen in strawberry (Fragaria ananassa) is homologous to the major birch pollen allergen Bet v 1, which has numerous isoforms differing in terms of amino acid sequence and immunological impact. To map the extent of sequence differences in the Fra a I allergen, PCR cloning and sequencing was applied. Several genomic sequences of Fra a 1, with a length of either 584, 591 or 594 nucleo

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Popular Abstract in Swedish Reklamen är ett oundvikligt inslag i vår vardagsmiljö och en viktig del av vår dagliga massmediekonsumtion. I den här studien har jag använt mig av tre italienskspråkiga reklambudskap för olivolja (Carapelli), pasta (Voiello) och kaffe (Lavazza) . I syfte att kunna belysa vilken viktig roll mottagarens sociokulturella bakgrund och encyklopediska kunskapsnivå spelar för The aim of this study is to describe how Italian advertising for olive oil, pasta and coffee reflects traditions, customs and culturally specific patterns regarding the ways in which these products are used in Italy, and how these culturally specific patterns are interpreted by native readers and non-native readers (Swedish students). The study is based on 22 Italian and 22 Swedish interpretations

U-Pb geochronology and paleomagnetism of the Westerberg Sill Suite, Kaapvaal Craton - Support for a coherent Kaapvaal-Pilbara Block (Vaalbara) into the Paleoproterozoic?

Precise geochronology, combined with paleomagnetism on mafic intrusions, provides first-order information for paleoreconstruction of crustal blocks, revealing the history of supercontinental formation and break-up. These techniques are used here to further constrain the apparent polar wander path of the Kaapvaal Craton across the Neoarchean-Paleoproterozoic boundary. U-Pb baddeleyite ages of 2441

Cytokines induce increased endothelin ET(B) receptor-mediated contraction

The effect of cytokines on the induction of contractile endothelin ET(B) receptors during organ culture was examined. Ring segments of rat superior mesenteric artery were used fresh or incubated for 24 h in Dulbecco's modified Eagle's medium alone, or with either interleukin-1beta, tumor necrosis factor-alpha (TNF-alpha) or interleukin-2. In fresh arterial segments there was no endothelin ET(B) re

Comparison of genotyping methods by application to Salmonella livingstone strains associated with an outbreak of human salmonellosis

During 2000 and 2001, an outbreak of human salmonellosis occurred in Sweden and Norway, caused by Salmonella livingstone. In this study, the genotypic differences between three strains obtained from food sources during the outbreak, two human strains and 27 more or less unrelated strains were analysed, using the three methods; automated ribotyping, pulsed field get electrophoresis (PFGE) and rando

Blue straggler production in globular clusters

Recent Hubble Space Telescope observations of a large sample of globular clusters reveal that every cluster contains between 40 and 400 blue stragglers.The population does not correlate with either stellar collision rate (as would be expected if all blue stragglers were formed via collisions) or total mass (as would be expected if all blue stragglers were formed via the unhindered evolution of a s

Bezafibrate-induced anaphylactic shock: unusual clinical presentation

We report a case of a patient who suffered generalized urticaria, chest tightness, wheezing, nausea, vomiting, hypotension, and loss of consciousness. Two hours earlier she had taken Eulitop Retard following lunch. She had tolerated all the implicated food after the reaction. Allergy evaluation revealed intense positive responses to intradermal tests with bezafibrate active component and Eulitop R

Coulomb excitation of Sn-110 using REX-ISOLDE

In this paper, we report the preliminary result from the first Coulomb excitation experiment at REX-ISOLDE (Habs et al 1998 Nucl. Instrum. Methods B 139 128) using neutron-deficient Sn-beams. The motivation of the experiment is to deduce the reduced transition probability, B(E2; 2(+) -> 0(+)), for the sequence of neutron deficient, unstable, even-even Sn- isotopes from Sn-110 to ultimately Sn-110.

Nuclear targeting of macromolecular polyanions by an HIV-Tat derived peptide: role for cell-surface proteoglycans.

New therapies, based on gene transfer and protein delivery, require a better understanding of the basic mechanisms of macromolecular membrane transport. We have studied cellular uptake of macromolecular polyanions, i.e. DNA and glycosaminoglycans, and a polybasic HIV-Tat derived peptide (GRKKRRQRRRPPQC), using fluorescence assisted cell sorting and confocal fluorescence microscopy. The Tat peptide

Theoretical study of the structural and spectroscopic properties of stellacyanin

The electronic spectrum of the azurin Met121Gln mutant, a model of the blue copper protein stellacyanin, has been studied by ab initio multiconfigurational second-order perturbation theory (the CASPT2 method), including the effect of the protein and solvent by point charges. The six lowest electronic transitions have been calculated and assigned with an error of less than 2400 cm-1. The ground-sta

Healthcare Matching - A Value Creating Service

Background: Long waiting times have been a significant problem in theSwedish health care system. A lack of matching of pathways of care has ledto long waiting times for patients, increasing medical risk and contributingtowards less effective capacity utilisation. There are different pathways into theelective healthcare system in Sweden, some via referral from a physician andothers via referral wri

Oxygen for breathlessness in patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy

Background: Breathlessness is a cardinal symptom of chronic obstructive pulmonary disease (COPD). Long-term oxygen therapy (LTOT) is given to improve survival time in people with COPD and severe chronic hypoxaemia at rest. The efficacy of oxygen therapy for breathlessness and health-related quality of life (HRQOL) in people with COPD and mild or no hypoxaemia who do not meet the criteria for LTOT

Cloning and characterisation of Aspergillus niger genes encoding an alpha-galactosidase and a beta-mannosidase involved in galactomannan degradation

α-Galactosidase (EC 3.2.1.22) and β-mannosidase (EC 3.2.1.25) participate in the hydrolysis of complex plant saccharides such as galacto(gluco)mannans. Here we report on the cloning and characterization of genes encoding an α-galactosidase (AglC) and a β-mannosidase (MndA) from Aspergillus niger. The aglC and mndA genes code for 747 and 931 amino acids, respectively, including the eukaryotic signa

Anatomy and biomechanics of the back muscles in the lumbar spine with reference to biomechanical modeling

Study Design. This article describes the development of a musculoskeletal model of the human lumbar spine with focus on back muscles. It includes data from literature in a structured form. Objective. To review the anatomy and biomechanics of the back muscles related to the lumbar spine with relevance for biomechanical modeling. Summary of Background Data. To reduce complexity, muscle units have be