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Background Colon cancer incidence is rising globally, and factors pertaining to urbanization have been proposed involved in this development. Traffic noise may increase colon cancer risk by causing sleep disturbance and stress, thereby inducing known colon cancer risk-factors, e.g. obesity, diabetes, physical inactivity, and alcohol consumption, but few studies have examined this. Objectives The o

To prevent diseases arising from exposure to toxic metals, more knowledge about their temporal changes is needed, especially in children, the most vulnerable group. This study follows temporal changes in blood lead (BPb), mercury (BHg) and cadmium (BCd) levels in schoolchildren (8–11 years old) from two cities in southern Sweden. One blood sample per 773 children was used for time trend analyses b

Background: An accurate medication list at hospital admission is essential for the evaluation and further treatment of patients. The objective of this study was to describe the frequency, type and predictors of errors in medication history, and to evaluate the extent to which standard care corrects these errors.Methods: A descriptive study was carried out in two medical wards in a Swedish hospital

Background. Whether disease burden in patients with metastatic castration-sensitive prostate cancer (mCSPC) predicts treatment outcomes is unknown. We assessed apalutamide treatment effect in TITAN patients with mCSPC by disease volume, metastasis number and timing of metastasis presentation. Methods. These protocol-defined and post hoc analyses of the phase III randomised TITAN study evaluated cl

Introduction: Galectin-3 is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human KD = 25 nM; rabbit KD = 12 nM) and high oral bioavailability in rabbits and man. In this study the efficacy of

Atrial fibrillation (AF) is the most common arrhythmia in the world, leading to a significant burden to patients and the healthcare system. It is characterised by rapid and irregular atrial contractions stemming from disorganised electrical activity in the atria. The atrioventricular (AV) node regulates heart rate during AF by filtering electrical impulses from the atria.However, for persistent AF

Popular Abstract in Swedish Byggbranschen står inför stora utmaningar i att möta behovet av nya bostäder samtidigt som renoveringsbehovet av flerbostadshus är stort. Man beskylls ofta för bristande kvalitet och höga kostnader. Industriellt byggande har framförts som en lösning till problemen. I ett projekt på Lunds Universitet har två tillämpningar för industriellt byggande studerats: trähusbygganIndustrialized construction has over the years taken different expressions and gone through different phases depending on where inspiration has come from. In this project, industrialized construction has been studied in two applications: timber house manufacturing and renovation of multi-family houses. In Sweden industrialized production of timber houses is relatively strong in the housing sector

Introduction: Previous studies have demonstrated that common breast cancer susceptibility alleles are differentially associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumou

A building-integrated multifunctional PV/T solar window was suggested and developed by Andreas Fieber. The solar window is constructed of PV cells laminated on solar absorbers placed in a window behind the glazing. To reduce the costs of solar electricity, tiltable reflectors have been introduced in the construction to focus radiation onto the solar cells. The reflectors make it possible to contro

The overall aim of the work presented in this thesis was to evaluate the incidence, outcome and consequences within the 1st year of acute ACL injury of the knee. The KANON-study, a randomized controlled clinical trial comparing surgical and non-surgical treatment after acute ACL injury, was initiated and some results are included in this thesis. 642 subjects with acute knee injury were assessed in

This article investigates verb placement, especially verb second (V2), in post-puberty L2 learners of two closely related Germanic V2-languages, Swedish and German. Håkansson, Pienemann & Sayehli (2002) have adduced data from L1 Swedish-speaking learners of German in support of the claim that the syntactic property of V2 never transfers from the L1 to L2 interlanguage grammars. Regardless of L

Exposure to organic dust originating from biofuels can cause adverse health effects. In the present study we have assessed the dustiness in terms of microbial components and particles of various biofuels by using a rotating drum as a dust generator. Microbial components from straw, wood chips, wood pellets and wood briquettes were quantified by several methods. Excellent correllations (r greater t

Natural product chemistry is a main research area in Cameroon, as well as for the division of Bioorganic Chemistry at Lund Institute of Technology. A review of the results obtained recently with Cameroonian medicinal plants shows that a large number of compounds, many with complex structures, have been isolated and characterised, and the work presented in this thesis is part of this effort. Based

Introduction: Per- and polyfluoroalkyl substances (PFAS) concentration limits in drinking water have been decreased or are going to be decrease worldwide. Drinking water is the single largest input to our bodies, with 2-2.5 L/day for adults. However, current water treatment techniques are inefficient to remove PFAS from drinking water. Therefore, there is an urgent need to develop sustainable inno

Background: Whether disease burden in patients with metastatic castration-sensitive prostate cancer (mCSPC) predicts treatment outcomes is unknown. We assessed apalutamide treatment effect in TITAN patients with mCSPC by disease volume, metastasis number and timing of metastasis presentation. Methods: These protocol-defined and post hoc analyses of the phase III randomised TITAN study evaluated cl

BACKGROUND: Maintenance of the botanical integrity of cereal kernels and the addition of acetic acid (as vinegar) in the product or meal has been shown to lower the postprandial blood glucose and insulin response and to increase satiety. However, the mechanism behind the benefits of acetic acid on blood glucose and satiety is not clear. We hypothesized that the gastric emptying rate could be invol

Hybrid vehicles have attracted tremendous attention during the last years. Increasing environmental concern and a steady increase in fuel prices are key factors for the growing interest. Hybrid vehicles, which benefits from having at least two different energy converters and two different energy storage systems, have proven to have significant potential to improve fuel economy without reducing the

The demand for energy in the world is increasing steadily. As the standard of living for people in the developing countries is increasing so is the net energy use per capita. The main contributor to the energy consumption is the use of fossil fuels, which is also the major emission source for carbon dioxide. Carbon dioxide is in turn one of the most significant greenhouse gases and will enhance te

In this article, we discuss Swedish crisis management from the perspective that public administration has evolved from a government steering structure to a governance structure. The power to govern crisis policy has been partly transferred from "government" to autonomous policy networks, which may include both public and private actors. Geographic area responsibility is assigned to the Government

BACKGROUND: Concerns remain about the human reproductive toxicity of the widespread per- and polyfluoroalkyl substances (PFAS) during early stages of development. OBJECTIVES: We examined associations between maternal plasma PFAS levels during early pregnancy and male offspring reproductive function in adulthood. METHODS: The study included 864 young men (age range:18.9-21.2 y) from the Fetal Progr