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Multi-electron donation remains a challenge for CO2 photocatalytic conversion to multi-electron products due to the efficient Auger recombination or annihilation at multiple excitation conditions for conventional molecules or semiconductor photocatalysts. In this paper, we demonstrated possible multi-electron donation within a quantum dot (QD)/metal complex hybrid photocatalyst system when multipl

On March 30, 2022, Inno4Vac, a public-private partnership funded by the IMI2/EU/EFPIA Joint Undertaking (IMI2 JU), organised a hybrid workshop, titled “Regulatory Dialogue for Road Maps of Implementation of New Tools in Chemistry, Manufacturing, and Controls Dossiers.” This event brought together modellers, regulatory experts, and academic and industry professionals specialising in vaccine process

Introduction: Radiographic progression-free survival (rPFS) by Prostate Cancer Working Group (PCWG) criteria is a radiographic endpoint. The automated bone scan index (aBSI) quantifies osseous disease burden on bone scintigraphy as a percentage of total skeletal weight. Using the aBSI, we sought to quantify increase in tumor burden represented by PCWG progression criteria, and to determine the int

This paper presents the results of a global sensitivity analysis (GSA) of a phenomenological model that generates dynamic wastewater treatment plant (WWTP) influent disturbance scenarios. This influent model is part of the Benchmark Simulation Model (BSM) family and creates realistic dry/wet weather files describing diurnal, weekend and seasonal variations through the combination of different gene

The present study aimed to investigate the effects of separate and simultaneous dietary intake of atorvastatin (ATO) and the soluble fiber oat bran on serum and hepatic lipid levels and the degree of atherosclerosis. Ninety female LDL-receptor-deficient (LDLr-/-) mice were fed a Western-type diet containing either low dose (0.0025%), high dose (0.01%) or no ATO, with or without oat bran (27%) (n =

AIMS: Atrial fibrillatory rate (AFR) is considered a non-invasive index of atrial remodelling. Low AFR has been associated with favourable outcome of interventions in patients with persistent atrial fibrillation (AF). However, AFR has never been studied in unselected patients with short duration of AF, prone to regain sinus rhythm (SR) spontaneously. The aim of the study was to assess if AFR can p

Many functions of galectin-3 entail binding of its carbohydrate recognition site to glycans of a glycoprotein, resulting in cross-linking thought to be mediated by its N-terminal non-carbohydrate-binding domain. Here we studied interaction of galectin-3 with the model glycoprotein asialofetuin (ASF), using a fluorescence anisotropy (FA) assay to measure the concentration of free galectin carbohydr

Vegetation is known to have different effects in shallow water environments, including changes in hydrodynamics. This often creates the need to include vegetation in large scale hydrodynamic models, which nowadays can already be achieved using some software packages available in the market. This work, however, had the purpose to test simple methods to simulate vegetation in hydrodynamic models wit

Sera from 25 metastatic breast cancer patients and 25 healthy controls were subjected to affinity chromatography using immobilized galectin-1. Serum from the healthy subjects contained on average 1.2 mg per ml (range 0.7-2.2) galectin-1 binding glycoproteins, whereas serum from the breast cancer patients contained on average 2.2 mg/ml (range 0.8-3.9), with a higher average for large primary tumour

International water resources agreements for transboundary rivers in southern Africa are generally founded in system analysis models for water planning and allocation. The Water Resources Yield Model (WRYM) developed in South Africa has so far been the only model applied in official joint water resources studies aimed to form water-sharing agreements. The continuous discussion around the model per

Environmental conditions and human activities play a significant role in structuring novel assemblages of native and non-native species. Ongoing and future climatic change may alter the performance of native and non-native species and their biotic interactions. In the northern hemisphere, expected climate changes include warmer temperatures and higher precipitation, the latter of which may increas

BACKGROUND/AIM: The value of androgen receptor (AR) in breast cancer has gained renewed interest as a prognostic and treatment predictive biomarker. The aims of this work were to study the associations and the prognostic value of AR in patients from two clinical cohorts.MATERIALS AND METHODS: Cohort 1 included 208 premenopausal, node-negative patients of whom 87% had received no adjuvant medical t

BACKGROUND: Pressure-volume (PV) loops provide a wealth of information on cardiac function but are not readily available in clinical routine or in clinical trials. This study aimed to develop and validate a noninvasive method to compute individualized left ventricular PV loops. METHODS: The proposed method is based on time-varying elastance, with experimentally optimized model parameters from a tr

Rye kernel bread (RKB) evening meals improve glucose tolerance, enhance appetite regulation and increase satiety in healthy volunteers. These beneficial effects on metabolic responses have been shown to be associated with increased gut fermentation. The present study aimed to elucidate if RKB evening meals may cause rapid alterations in microbiota composition that might be linked to metabolic-, im

The purpose of this study was to assess the association between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) in plasma, a biomarker of exposure to polychlorinated biphenyls (PCB), and time to pregnancy (TTP) in a group of women with a varying dietary exposure to PCB. For 121 Swedish east coast fishermen's wives (median year of birth 1956, range 1945-1968), information on selt-reported TTP for the fi

The 3-hydroxy fatty acids (3-OHFAs) in lipopolysaccharides (LPS) play an important role in determining endotoxin activity, and childhood exposure to endotoxin has recently been associated with reduced risk of atopic diseases. To characterize the 3-OHFAs in house dust (HD), we used gas chromatography-mass spectrometry to assay 190 HD samples. Dust from beds, bedroom floors, family rooms, and kitche

OBJECTIVES:: To study the prognostic value of fever in the emergency department in septic patients subsequently admitted to the ICU. DESIGN:: Observational cohort study from the Swedish national quality register for sepsis. SETTING:: Thirty ICU’s in Sweden. PATIENTS:: Two thousand two hundred twenty-five adults who were admitted to an ICU within 24 hours of hospital arrival with a diagnosis of sev

Background: Previous studies showed that lifestyle behaviors (cigarette smoking, alcohol, coffee) are inversely associated with Parkinson's disease (PD). The prodromal phase of PD raises the possibility that these associations may be explained by reverse causation. Objective: To examine associations of lifestyle behaviors with PD using two-sample Mendelian randomisation (MR) and the potential for

In a non-negligible number of patients with metastatic colorectal cancer (mCRC), the peritoneum is the predominant site of dissemination. Cure can be achieved by cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), but this procedure is associated with long-term morbidity and high relapse rates. Thus, there is a pressing need for improved therapeutic strategies and co

Background: Per- and polyfluoroalkyl substances (PFAS) are a large family of persistent industrial chemicals with endocrine disrupting properties. Objectives: To examine biomarkers of reproductive function in young adult males according to current environmental exposure to single and combined PFAS. Methods: The study population consisted of young men (n = 1041, age 18–21) from the Fetal Programmin