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Impact of site-specific conjugation strategies on the pharmacokinetics of antibody conjugated radiotherapeutics

Antibody radionuclide conjugates are an emerging modality for targeted imaging and potent therapy of disseminated disease. Coupling of radionuclides to monoclonal antibodies (mAbs) is typically achieved by applying non-site-specific labelling techniques. With the ambition of reducing variability, increasing labelling efficacy and stability, several site-specific conjugation strategies have been de

Sensorless method of detecting plunger position in solenoid actuators

This thesis investigates if it is possible to measure the plunger position in a Ledex 282352-023 solenoid actuator without the use of external sensors. To do this, various different methods, all based on comparing the current response to the applied voltage were evaluated from different categories such as calculation time, reliability and distinct position levels. The method that performed best in

Engineering of pyranose 2-oxidase: Improvement for biofuel cell and food applications through semi-rational protein design

Pyranose 2-oxidase (P20x) has several proposed biotechnological applications such as a bio-component in biofuel cells or for carbohydrate transformations. To improve some of the catalytic properties of P20x from Trametes multicolor, we selected a semi-rational approach of enzyme engineering, saturation mutagenesis of active-site residues and subsequent screening of mutant libraries for improved ac

Family caregivers of persons with dementia. Experiences of burden, satisfaction and psychosocial intervention.

Popular Abstract in Swedish När en familjemedlem drabbas av en demenssjukdom påverkas även de övriga familjemedlemmarna på något sätt. Allt mer vård och omsorg flyttar in i hemmen och de närståendes roll och funktion blir mycket centrala. Syftet med denna doktorsavhandling var att undersöka hur närstående till demenssjuka personer mår, och att planera, genomföra och undersöka effekten av en 5-vec

Monte Carlo simulations of a clay inspired model suspension: the role of rim charge

We present a theoretical investigation of a model clay dispersion in 1-1 salt solutions by varying the particle volume fraction and ionic strength as well as the charge distribution on the clay platelets. The platelets are modeled as discs with charged sites distributed on a hexagonal lattice. The edge sites can be positively charged while the remaining sites are negative giving rise to a strong c