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Accelerated cell aging, indexed in peripheral leukocytes by telomere shortness and in peripheral blood mononuclear cells (PBMCs) by telomerase activity, has been reported in several studies of major depressive disorder (MDD). However, the relevance of these peripheral measures for brain indices that are presumably more directly related to MDD pathophysiology is unknown. In this study, we explored

Background Dehydroepiandrosterone (DHEA) and its sulfated ester DHEA-sulfate (DHEA-S), (together DHEA[S]), are the most abundant adrenal steroids in humans and are found in blood and the brain, where they function as neurosteroids with direct receptor affinities. Preclinical studies suggest that DHEA(S) has antidepressant/neuroprotective properties, and exogenously administered DHEA has shown anti

A housing adaptation (HA) can enable independent living in one's own home, but deciding to change the home environment can be a thought-provoking matter. The aim of this study was to explore the applicant's perspective and decision-making process when applying for an HA grant. Seventeen persons were interviewed about their application for such a grant, and the data were analyzed using a constant c

Grand challenges such as climate change put focus away from innovations and innovation policy as engines of economic growth towards fulfilling societal goals and sighting sustainable development. The literature on the geography of innovation has provided valuable insights on innovation activities of firms and industries and how they are positively influenced by co-location. In particular, short ge

BackgroundPeople with intellectual disability have been found to have higher prevalence of psychiatric disorders than the general population. However, they do not seem to have a corresponding increase in psychiatric care utilization. The aim of the present study was to investigate psychiatric care utilization among older people with intellectual disability.MethodsWe used a cohort of people with in

To reduce greenhouse gas (GHG) emissions and help mitigate climate change, urban water systems need to be adapted so that electrical energy use is minimised. In this study, energy data from 2011 was used to quantify energy use in China’s urban water supply sector. The objective was to calculate the energy co-benefits of urban water conservation policies and compare energy use between China and oth

A study is presented of the impact on science data from extremely large telescopes of a transformation of wavelength base for optimization of actuator architecture from 2 200 to 1250 nm. From the optical path difference (OPD) data for Euro50, we transform to E-ELT OPDs. We compute the corresponding power spectrum, in which we simulate a higher actuator density via high-pass filtering to convert fr

The rapid progress in scanning probe microscopy (SPM) techniques in the last decade has induced an increasing need for manufacturing advanced SPM tips. One important case is conductive and transparent tips. For such tips, only a few techniques have been proposed. which are either expensive or have poor reproducibility. We here propose a simple and cheap sol-gel technique to prepare fibers with a s

In the course of 2000s, the region of Campania in southern Italy and its capital city Naples became global icons of waste mismanagement after the images of piles of rubbish occluding their urban areas hit the headlines. Conventional explanations, in Italy and elsewhere, pointed to administrative failure, cultural backwardness and mafia infiltration as the main causes of waste mishandling. In the s

Structural technologies are an essential component in the design of precision therapeutics. Precision medicine entails the development of therapeutics directed toward a designated target protein, with the goal to deliver the right drug to the right patient at the right time. In the field of oncology, protein structural variants are often associated with oncogenic potential. In a previous proteogen

I review formation channels for blue stragglers. I consider how they may be produced via collisions between two single main-sequence stars, or via collisions during encounters involving binary stars. Further, I discuss how blue stragglers may be produced via the evolution of isolated binaries. Observations of globular clusters suggest that both mechanisms are contributing.

Känslors roll i vår relation till skönlitteratur är ett snabbt växande forskningsfält alltsedan « the affective turn » i början av 2000-talet, bl.a. tack vare forskare som Suzanne Keen (2007), Martha Nussbaum (2001), Jenefer Robinson (2005) och Jean-François Vernay (2013), även om man fortfarande inte vet mycket om verkliga läsares känslor. Ändå har affekter, emotioner och känslor inte alls en sj

The 2010 population and housing census in Ghana revealed that more than half of the Ghanaian population lived in urban centers. Critical to the phenomenon of urbanization is the question of how to sustainably feed the urban population especially the urban poor as rapid urbanization has the tendency to urbanize poverty. This has led to renewed policy debate about the implications of farming in citi

Studiens syfte var att nå en fördjupad förståelse av timeouter i handboll, hur de används och vad som kommuniceras. En fallstudie genomfördes med ett herrhandbollslag i den högsta divisionen i svensk handboll. En kombinerad kvantitativ och kvalitativ metod användes där tränarens kommunikation kategoriserades med hjälp av Hasties (1999) instrument för skattning av tränarkommunikation under timeout.The purpose of this study was to gain a deeper understanding of timeouts in handball, how they are used and what is communicated. A case study was performed with a men’s handball team in the top division in Swedish handball. A combined quantitative and qualitative method was used where the coach’s communication was categorized using Hastie’s (1999) instrument for assessment of coach communication

This report evaluates and compares the methods in fire inspection at Malmø Fire Brigade and Copenhagen Fire Brigade. The report also examines fire safety laws and regulations and the educational differences of the fire inspectors in Malmø and Copenhagen. The investigation is a project for Malmø Fire Brigade and Copenhagen Fire Brigade in co-operation with the Department of Fire Safety Engineering

Syftet med studien var att kvalitativt undersöka kvinnliga fotbollsspelares upplevelse av att nå elitnivå. Semistrukturerade intervjuer användes och totalt intervjuades tre deltagare. Intervjuerna analyserades med IPA (Interpretative Phenomenological Analysis) som metodologisk ansats. Totalt kunde fem teman urskiljas som centrala i upplevelsen av elitnivå: tankar och känslor kopplade till övergångThe purpose of this study was to qualitatively explore the experience of reaching the elite level for women in football. Semi-structured interviews were conducted with three participants. The interviews were analysed using Interpretative Phenomenological Analysis (IPA). In total, five themes emerged: thoughts and feelings associated with reaching the elite level, social support, gender identity, m

I juni 2011 antog ILO konventionen om goda villkor för hushållsarbetare. Konventionen fastställer anställningsvillkor och arbetsrättigheter för hushållsarbetare. Hushållsarbete sker, till skillnad från andra former av arbete, i privata hem utan insyn från det offentliga och är ofta ett ensamarbete. Detta innebär att hushållsarbetare riskerar att bli utsatta för missförhållanden och exploatering. KIn June 2011, the Domestic Workers Convention was adopted in the ILO. The Convention establishes minimum conditions of employment and labour rights for domestic workers. In contrast to other types of work, domestic work takes place in private households, in isolation and hidden from public insight. This makes domestic workers vulnerable to abuse and exploitation. The Domestic Workers Convention ob