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Germ layer formation and primary axis development rely on Fibroblast growth factors (FGFs). In Xenopus, the secreted serine protease HtrA1 induces mesoderm and posterior trunk/tail structures by facilitating the spread of FGF signals. Here, we show that the serpin Protease nexin-1 (PN1) is transcriptionally activated by FGF signals, suppresses mesoderm and promotes head development in mRNA-injecte
SimSWE is a library of components for modeling and simulation of software engineering processes. It consists of a generic, implementation independent description of the components and a reference implementation using the MATLAB® / Simulink® environment. By providing ready-to-use building blocks for typical functionality, the library should facilitate and ease the use of simulation to analyze softw
The lack of human resources is one of the main bottlenecks to achieving the Millennium Development Goals on maternal and child health. A coherent national policy, recognized across government, needs to be in place to overcome this especially in countries severely affected by HIV/AIDS. Such a policy should cover selection of pre-service students, the qualifications of trainers and training sites, s
Aim: Does metabolic control improve in children with insulin dependent diabetes mellitus (IDDM), when modifying the quality of carbohydrates by introducing low glycaemic index (GI) foods? Methods: The inclusion criteria for the study was children with diabetes mellitus type 1, age from 7 to 11 years old, they should have a moderate glucose control with HbA1c between 7,5 to 8,5 and no allergy to ce
A study is presented of the impact on science data from extremely large telescopes of a transformation of wavelength base for optimization of actuator architecture from 2 200 to 1250 nm. From the optical path difference (OPD) data for Euro50, we transform to E-ELT OPDs. We compute the corresponding power spectrum, in which we simulate a higher actuator density via high-pass filtering to convert fr
The rapid progress in scanning probe microscopy (SPM) techniques in the last decade has induced an increasing need for manufacturing advanced SPM tips. One important case is conductive and transparent tips. For such tips, only a few techniques have been proposed. which are either expensive or have poor reproducibility. We here propose a simple and cheap sol-gel technique to prepare fibers with a s
GABA is the major inhibitory neurotransmitter in the CNS and changes in GABAergic neurotransmission affect the overall activity of neuronal networks. The uptake of GABA into synaptic vesicles is mediated by the vesicular GABA transporter (VGAT), and changes in the expression of the transporter directly regulate neurotransmitter release. In this work we investigated the changes in VGAT protein leve
Mucosal surfaces of the reproductive tract as well as their secretions have important roles in preventing sexual transmission of HIV-1. In the current study, the majority of the intrinsic anti-HIV-1 activity of human seminal plasma (SP) was determined to reside in the cationic polypeptide fraction. Antiviral assays utilizing luciferase reporter cells and lymphocytic cells revealed the ability of w
This report evaluates and compares the methods in fire inspection at Malmø Fire Brigade and Copenhagen Fire Brigade. The report also examines fire safety laws and regulations and the educational differences of the fire inspectors in Malmø and Copenhagen. The investigation is a project for Malmø Fire Brigade and Copenhagen Fire Brigade in co-operation with the Department of Fire Safety Engineering
In the course of 2000s, the region of Campania in southern Italy and its capital city Naples became global icons of waste mismanagement after the images of piles of rubbish occluding their urban areas hit the headlines. Conventional explanations, in Italy and elsewhere, pointed to administrative failure, cultural backwardness and mafia infiltration as the main causes of waste mishandling. In the s
Structural technologies are an essential component in the design of precision therapeutics. Precision medicine entails the development of therapeutics directed toward a designated target protein, with the goal to deliver the right drug to the right patient at the right time. In the field of oncology, protein structural variants are often associated with oncogenic potential. In a previous proteogen
I review formation channels for blue stragglers. I consider how they may be produced via collisions between two single main-sequence stars, or via collisions during encounters involving binary stars. Further, I discuss how blue stragglers may be produced via the evolution of isolated binaries. Observations of globular clusters suggest that both mechanisms are contributing.
Känslors roll i vår relation till skönlitteratur är ett snabbt växande forskningsfält alltsedan « the affective turn » i början av 2000-talet, bl.a. tack vare forskare som Suzanne Keen (2007), Martha Nussbaum (2001), Jenefer Robinson (2005) och Jean-François Vernay (2013), även om man fortfarande inte vet mycket om verkliga läsares känslor. Ändå har affekter, emotioner och känslor inte alls en sj
The 2010 population and housing census in Ghana revealed that more than half of the Ghanaian population lived in urban centers. Critical to the phenomenon of urbanization is the question of how to sustainably feed the urban population especially the urban poor as rapid urbanization has the tendency to urbanize poverty. This has led to renewed policy debate about the implications of farming in citi
Today, innovation is a key word for many universities, as it constitutes an important part of most universities’ public and scientific interaction with society. Many universities are striving to increase the number of innovations spun out. At many universities, innovations are thought of as being sprung from research projects and generated by researchers. However, Sandström (2014) claims that whil
Aviation fuel is a petroleum product that fulfills the Standard Specification for Aviation Turbine Fuels. Crude oil has been the raw material for production of aviation fuels for many years. Since the availability of crude oil is predicted to be limited in the future, alternative raw materials for aviation fuels are highly desirable. A Swedish company, Oroboros AB, has developed a novel clean synt
