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Treatment with anti-CD20 antibodies is only moderately efficient in chronic lymphocytic leukemia (CLL), a feature which has been explained by the inherently low CD20 expression in CLL. It has been shown that CD20 is epigenetically regulated and that histone deacetylase inhibitors (HDACis) can increase CD20 expression in vitro in CLL. To assess whether HDACis can upregulate CD20 also in vivo in CLL

Fuel and load flexibility have been increasingly important features of industrial gas turbines in order to meet the demand for increased utilization of renewable fuels and to provide a way to balance the grid fluctuations due to the unsteady supply of wind and solar power. Experimental investigations were performed using a standard 3rd generation dry low emission (DLE) burner under atmospheric pre

The mental health of the health workforce has been receiving more attention, especially since the pandemic. Levels of burnout, moral injury, and mental disorders, including suicide, among physicians are cause for concern. Healthcare leadership in workplaces plays a crucial role in addressing this important issue, which is also related to the ability to attract and retain physicians. This chapter p

Manganese tetra-pyridyl-porphyrins are found to self-organize in an ordered monolayer on graphene. Moreover, post deposition of cobalt ad-atoms steers the geometric reordering of the layer, yielding the formation of a self-assembled bimetallic network, where both Mn and Co are tetra-coordinated with nitrogen. While manganese shifts from Mn(ii) towards the +2/+3 oxidation state range, depending on

Nickel (Ni) is the key component in ohmic contacts for Mg-doped p-GaN, but the detailed formation mechanisms of the ohmic contact have not yet been understood. In this work, the effect of potassium hydroxide (KOH)-based chemical treatment on the surface of p-GaN is investigated using X-ray photoelectron spectroscopy (XPS), scanning tunneling microscopy (STM), and low-energy electron diffraction (L

Introduction: Residual cognitive deficits are commonly reported by individuals in remission from depression, often affecting daily life functioning and mental health. To provide tailored and personalized cognitive enhancement interventions for this population, there is a need for a better understanding of the characteristics of those who benefit from such interventions. Therefore, this study aimed

Artificiell intelligens har under de senaste åren fått en allt större betydelse inom hälso- och sjukvården. En framväxande tillämpning är AI-verktyg för journalföring, som automatiserar delar av det administrativa arbetet genom att omvandla tal till text, strukturera anteckningar och i vissa fall föreslå diagnoser eller remisser. Verktygen kan effektivisera vårdpersonalens arbete, men väcker samtiIn recent years, artificial intelligence has gained increasing importance within the healthcare sector. One emerging application is AI medical scribes, which automate parts of administrative work by converting speech to text, structuring clinical notes, and in some cases suggesting diagnoses or referrals. These tools have the potential to improve the efficiency of healthcare professionals, but at

Membrane bioreactor (MBR) has been recognized as an advanced water treatment technology to remove diverse impurities from various water resources (such as wastewater, surface water, groundwater, and rainwater). In MBRs, membrane separation and biodegradation are synergized to enhance pollutant removals in order to achieve treated water of superior quality. Pressure-driven microfiltration (MF)/ultr

We propose data-driven surrogate models to solve systems of time-dependent differential equations coupled with noise. Using a feedforward neural network, we separately learn the noise and solution, tackling approximations across regimes with bifurcations and rare events. Focusing on irregular data generated by a stochastic noise model on a one-dimensional spatial lattice coupled to a differential

This article examines the overlaps between the AI Act and the GDPR, analysing their overall relationship, conceptual similarities and differences, as well as specific provisions in the AI Act that explicitly overlap with the GDPR. The primary focus of this article lies on AI data governance, with a detailed analysis of the requirements set out in Article 10 AI Act. This provision establishes quali

Purpose: Genital malformations are increasingly recognized when a VACTERL is present, but remain insufficiently described in children with esophageal atresia (EA). This study aimed to determine the prevalence and spectrum of genital and urinary tract malformations in children with EA, and to describe associated morbidity, need for additional surgery, and association with Gross classification. Meth

Lifestyle factors are important for clinical outcome. Systematic and early identification of these factors is important in order to offer relevant lifestyle intervention programmes. The objective was to evaluate whether basic registration of risk factors was understandable, applicable and sufficient in the clinical workday.

This paper is based on a roundtable discussion held in September 2016 as part of the Pedagogical Inspiration Conference for teachers at the Faculties of Humanities and Theology at Lund University (LU). The roundtable was meant to focus specifically on the consequences of the lack of permanent teaching positions for the quality of the pedagogical work carried out at LU. However, as will be discusse

Purpose: This study aims to focus on the surface curvature, jet to target spacing and jet Reynolds number effects on the heat transfer and fluid flow characteristics of a slot jet impinging on a confined concave target surface at constant jet to target spacing. Design/methodology/approach: Numerical simulations are used in this research. Jet to target spacing, H/B is varying from 1.0 to 2.2, B is

This article presents the results of a questionnaire survey carried out during the spring of 2000. The results are based on the answers provided by a total of 99 respondents. Among other results the survey revealed that more than half of the responding companies have a formally documented strategy for product development work. Regarding disciplinary competencies, it is shown that design engineers

The transmembrane protein Dystroglycan is a central element of the dystrophin-associated glycoprotein complex, which is involved in the pathogenesis of many forms of muscular dystrophy. Dystroglycan is a receptor for multiple extracellular matrix (ECM) molecules such as Laminin, agrin and perlecan, and plays a role in linking the ECM to the actin cytoskeleton; however, how these interactions are r