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The remarkable advancements in basic stem cell research with implications for several central nervous system disorders have so far not been translated into clinically effective therapies. Here I discuss some of the underlying problems and how they could be overcome.
The objective was to identify inflammatory biomarkers that predict risk of 90-day mortality in patients with acute dyspnea.
Orthostatic hypotension (OH) increases the risk of incident cardiovascular disease (CVD) and all-cause mortality in population-based cohort studies. Whether OH is associated with development of cardiac anomalies has not been sufficiently explored.
OBJECTIVE: Insulin-like growth factor-1 (IGF-1) is essential for the pubertal growth spurt and for normal mammary gland development. IGF-1 increases premenopausal breast cancer risk. Oral contraceptives (OCs) decrease IGF-1 in most women. The endogenous estrogens and their metabolites also influence IGF-1 levels. Glutathione S-transferases (GSTs) are involved in estrogen metabolism. We aimed to st
DELLSON P., NILBERT M., BENDAHL P-O., MALMSTROM P. & CARLSSON C. (2010) European Journal of Cancer Care Towards optimised information about clinical trials; identification and validation of key issues in collaboration with cancer patient advocates Clinical trials are crucial to improve cancer treatment but recruitment is difficult. Optimised patient information has been recognised as a key iss
The human fetal ventral mesencephalon-derived stem cell line, hVM1, yields high number of tyrosine hydroxylase-expressing presumed dopaminergic neurons upon in vitro differentiation. Here we report that cells generated from this line differentiate into a neuronal phenotype, express electrophysiological properties of functional neurons and respond to neurotransmitters in vitro. However, the electro
Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by a functional haploinsufficiency of genes encoding for ribosomal proteins. Recently, a case study reported a patient who became transfusion-independent in response to treatment with the amino acid L-leucine. Therefore, we have validated the therapeutic effect of L-leucine using our recently generated mouse model for RPS19-
Ischemic stroke affecting the adult brain causes increased progenitor proliferation in the subventricular zone (SVZ) and generation of neuroblasts, which migrate into the damaged striatum and differentiate to mature neurons. Meteorin (METRN), a newly discovered neurotrophic factor, is highly expressed in neural progenitor cells and immature neurons during development, suggesting that it may be inv
Excitation energy transfer between photosynthetic light-harvesting complexes is vital for highly efficient primary photosynthesis. Controlling this process is the key for advancing the emerging artificial photosynthetic systems. Here, we experimentally demonstrate the enhanced excitation energy transfer between photosynthetic light-harvesting 2 complexes (LH2) mediated through the Fabry-Pérot opti
Green ammonia synthesis from nitrogen via photocatalysis and electrocatalysis has emerged as a pivotal research focus in sustainable chemical processes. The efficient catalytic reduction of nitrogen necessitates concurrent nitrogen activation and hydrogen evolution suppression, representing a significant challenge. In this study, CuAu bimetallic-modified TiO2 catalysts were developed and engineere
By combining ultrashort laser pulses with PEEM, time-resolved photoemission electron microscopy (TRPEEM) provides a powerful approach for investigating ultrafast charge carrier dynamics with simultaneous femtosecond temporal resolution and nanometer spatial precision. It has evolved into a versatile methodto study a wide range of phenomena, including charge carrier dynamics, surface plasmons, scat
Two-level systems (TLSs) are the basic units of quantum computers but face a trade-off between operation speed and coherence due to shared coupling paths. Here, we investigate a TLS given by a singlet-triplet (ST+) transition. We identify a magnetic-field configuration that maximizes dipole coupling while minimizing total dephasing, forming a compromise-free sweet spot that mitigates this fundamen
Developing novel organic photovoltaic materials for organic solar cells (OSCs) requires precise characterization of their charge transfer states to optimize the photoinduced charge transfer mechanisms within the photoactive layer. The microscopic photoelectric properties of the S-shaped (DYA-I-S) and O-shaped (DYA-I-O) conformations of dimeric small molecule acceptors (DSMAs) are analyzed through
Magic Angle Spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy is limited in spectral resolution by the spinning frequency of rotors that hold the analyte. Traditional yttria-stabilized zirconia (YSZ) rotors have mechanical constraints that typically limit spinning frequencies of 0.7 mm rotors to ωr/2π ∼ 110 kHz. These frequencies are not sufficient to achieve resolution comparable to th
With the development of ultrafast laser technology, time-resolved spectroscopy has become an essential tool to study the microscopic photophysical mechanisms on ultrafast time scales in the field of solar energy conversion and utilization. Transient absorption spectroscopy (TAS), as an essential technology for studying photoinduced ultrafast electron transfer and photo-induced carrier dynamics, ha
Background. Post-traumatic chondral and osteochondral lesions can be treated with autologous chondrocyte implantation (ACI), but the high cost of autologous cell expansion under strict Good Manufacturing Practice (GMP) regulations limits patient access. Stem cell–based advanced therapy medicinal products (ATMPs) offer more cost-effective alternatives, with human induced pluripotent stem cells (iPS
Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy1. They are implicated in multiple neurological disorders, including stroke, epilepsy and neurodegeneration, and can regulate neuronal excitability through interactions with ion channels2. Polyamines have been linked to pain, showing altered levels in human persistent pain states and mo
Solar-driven hydrogen production stores renewable energy chemically but suffers from efficiency limitations due to the slow hole transport-dominated recombination, which caused by high valence band degeneracy and hole effective mass. Targeted hole trap regulation is essential to minimize these losses and enhance photocatalytic H2 evolution performance for practical applications. This study address
Background: The eco-corona, consisting of environmental biomolecules formed around engineered nanomaterials (ENMs) when released to the environment, has gained increasing focus in the scientific literature and its role for ENM fate and toxicity is now widely acknowledged. The European chemicals legislation, REACH, entails reporting requirements when it comes to the transformation of nanoforms. Gui
Perovskites have attracted widespread attention for laser applications due to their excellent optoelectronic properties. However, perovskite lasers typically exhibit a wavelength shift as pump density increases. Here, we report a pump-induced wavelength shift-free laser achieved using a perovskite nanoplatelet with mixed orthorhombic and tetragonal phase. At 293 K, the tetragonal-phase perovskite
