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Children with cancer experience fragmented school attendance during treatment. Telepresence robots that connect them with school during treatment periods were explored through an intervention involving participant observation followed by semi-structured interviews from 2020–22 with children with cancer, their class teachers, and classmates. We used an abductive approach, inspired by the Agential R

Objectives To analyse potential biomarkers for vibration-induced nerve damage in a population-based, observational study. Design Prospective cohort study. Setting Malmö Diet Cancer Study (MDCS), Malmö, Sweden. Participants In a subcohort of 3898 individuals (recruited 1991-1996) from MDCS (baseline examination in 28 449 individuals; collection of fasting blood samples in a cardiovascular subcohort

Budd et al. challenge the identity of neural traces reported for the Cambrian lobopodian Cardiodictyon catenulum. Their argumentation is unsupported, as are objections with reference to living Onychophora that misinterpret established genomic, genetic, developmental, and neuroanatomical evidence. Instead, phylogenetic data corroborate the finding that the ancestral panarthropod head and brain is u

Coherent tunneling processes of multiple Cooper pairs across a Josephson junction give rise to high harmonics in the current phase relation. In this work, we propose and study Josephson junctions based on semiconductor-superconductor-ferromagnetic insulator heterostructures to engineer nonsinusoidal current-phase relations. The gate-tunability of the charge carriers' density in the semiconductor,

The new phase Mg7Pt4Ge4 (Mg8□1Pt4Ge4; □ = vacancy) was prepared by reacting a mixture of the corresponding elements at high temperatures. According to single crystal X-ray diffraction data, it adopts a defect variant of the lighter analogue Mg2PtSi (Mg8Pt4Si4), reported in the Li2CuAs structure. An ordering of the Mg vacancies results in a stoichiometric phase, Mg7Pt4Ge4. However, the high content

IntroductionForensic pathologists are frequently confronted with questions about the likelihood that an injury is inflicted by an assault or is self-inflicted. However, little is known of epidemiological variables applicable to differentiate between homicides and suicides in deaths caused by single stab injuries to the trunk. MethodUsing the Swedish forensic autopsy register we identified 94 homic

Phenotypic drug discovery (PDD) enables the target-agnostic generation of therapeutic drugs with novel mechanisms of action. However, realizing its full potential for biologics discovery requires new technologies to produce antibodies to all, a priori unknown, disease-associated biomolecules. We present a methodology that helps achieve this by integrating computational modeling, differential antib

STUDY QUESTION: Which substances and signal transduction pathways are potentially active downstream to the effect of FSH and LH in the regulation of human oocyte maturation in vivo? SUMMARY ANSWER: The regulation of human oocyte maturation appears to be a multifactorial process in which several different signal transduction pathways are active. WHAT IS KNOWN ALREADY: Many studies in animal species

Understanding of mass transfer in gas-liquid slug flow is imperative to design and optimize micro-reactors. There exist extensive studies on symmetric bubbles by the phase volume monitor technique, whereas deformed bubbles are rarely studied due to the limitation of volume calculation methods. In this work, CO2-water and N2-water two-phase flows were investigated in a square microchannel, obtainin

Sleep problems, in particular the difficulty in initiating and maintaining sleep are important comorbidities in children and adolescents with attention deficit hyperactivity disorder (ADHD), accompanied by a range of negative consequences for both patients and their caregivers. Melatonin, a naturally occurring hormone that is important for coordinating the body's sleep-wake cycle, has been used to

Si1−xGex nanowires (NWs) were prepared by gold-supported chemical vapor deposition (CVD) using a single-source precursor with preformed Si–Ge bonds. Besides the tamed reactivity of the precursor, the approach reduces the process parameters associated with the control of decomposition characteristics and the dosing of individual precursors. The group IV alloy NWs are single crystalline with a const

Objectives To develop a protocol for largescale analysis of synovial fluid proteins, for the identification of biological networks associated with subtypes of osteoarthritis. Methods Synovial Fluid To detect molecular Endotypes by Unbiased Proteomics in Osteoarthritis (STEpUP OA) is an international consortium utilising clinical data (capturing pain, radiographic severity and demographic features)

We consider the most energetically favorable symmetry-allowed spin-singlet and spin-triplet superconducting pairing symmetries in twisted bilayer graphene at the magic angle, whose normal state physics is described by a six-band effective tight-binding model. We compute the Chern number as a function of the superconducting order parameter strength and the chemical potential and we find a topologic

The inherently weak chiroptical responses of natural materials limit their usage for controlling and enhancing chiral light-matter interactions. Recently, several nanostructures with subwavelength scale dimensions were demonstrated, mainly due to the advent of nanofabrication technologies, as a potential alternative to efficiently enhance chirality. However, the intrinsic lossy nature of metals an

Estrogen influences T cell development and enhances infection resistance in females, but its immunological effects during gender-affirming hormone therapy (GAHT) remain poorly understood. Here, we characterize immune adaptations in male rhesus macaques (RMs) treated with 17β-estradiol (E2) or placebo over 7 months. E2 therapy suppressed endogenous testosterone production, induced female physical t

High-order harmonic generation (HHG) in gases leads to short-pulse extreme ultraviolet (XUV) radiation that is useful in a number of applications, such as attosecond science and nanoscale imaging. However, this process depends on many parameters, and there is still no consensus on how to choose the target geometry to optimize the source efficiency. We review the physics of HHG with emphasis on the

We aimed to investigate the genetic associations of neuropathic pain in a deeply phenotyped cohort. Participants with neuropathic pain were cases and compared with those exposed to injury or disease but without neuropathic pain as control subjects. Diabetic polyneuropathy was the most common aetiology of neuropathic pain. A standardised quantitative sensory testing protocol was used to categorize