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Incretin-based therapy is associated with low risk of hypoglycemia in type 2 diabetes mellitus (T2DM) possibly due to its glucose-dependency in stimulating insulin secretion and a sustained glucagon response during hypoglycemia. This is of special relevance when it is combined with insulin or given to elderly patients since both insulin therapy and high age are associated with impaired glucagon co

Background: Endometriosis and irritable bowel syndrome (IBS) have similar symptoms, pathogenesis, and risk factors. These diagnoses often coexist and are frequently misdiagnosed leading to diagnostic delays. This study of a population-based cohort aimed to investigate associations relating to endometriosis and IBS and to compare gastrointestinal symptoms between endometriosis and IBS. Method: The

Chronic pain including temporomandibular disorder (TMD) pain involves a complex interplay between peripheral and central sensitization, endogenous modulatory pathways, cortical processing and integration and numerous psychological, behavioral and social factors. The aim of this study was to compare spectroscopic patterns of N-Acetyl-aspartate (NAA), total creatine (tCr), choline (Cho), myo-inosito

At synchrotron light storage rings there is demand for serving high-brilliance users requesting multibunch operation while simultaneously serving timing users who require single-bunch operation. One method to accomplish this is PPRE developed and currently in user operation at BESSY II. In the method, the transverse emittance of one of the bunches in the bunch train is increased by an incoherent b

The human lung is a complex tissue consisting of a heterogeneous mix of different structures and cells, each which a specific role that together contribute to the primary function of the organ: the gas exchange. Different mesenchymal cells populate the interstitial areas around airways and blood vessels and form the connective tissue together with the extracellular matrix. Fibroblasts constitute o

Objective: To study the impact of GH dose and age at GH start in girls with Turner syndrome (TS), aiming for normal height and age at pubertal onset (PO) and at adult height (AH). However, age at diagnosis will limit treatment possibilities. Methods: National multicenter investigator-initiated studies (TNR 87-052-01 and TNR 88-072) in girls with TS, age 3–16 years at GH start during year 1987–1998

Background: Various factors modulate circulating testosterone in men, affecting interpretation of testosterone measurements. Purpose: To clarify factors associated with variations in sex hormone concentrations. Data Sources: Systematic literature searches (to July 2019). Study Selection: Prospective cohort studies of community-dwelling men with total testosterone measured using mass spectrometry.

Purpose: The purpose of this study is to investigate the effects of film holes’ arrangements and jet Reynolds number on flow structure and heat transfer characteristics of jet impingement conjugated with film cooling in a semicylinder double wall channel. Design/methodology/approach: Numerical simulations are used in this research. Streamlines on different sections, skin-friction lines, velocity,

Background: Previous studies have investigated [18F]-fluorocholine (FCH) positron emission tomography with computed tomography (PET/CT) in primary staging of men with intermediate or high-risk prostate cancer and have generally shown high specificity and poor sensitivity. FCH PET/CT is not recommended for the primary staging of metastases in the European guidelines for prostate cancer. However, it

Surrogate measures of safety (SMoS) are meant to function as tools to investigate traffic safety. The term surrogate indicates that these measures do not rely on crash data; instead, they focus on identifying safety critical events (or near-crashes) in traffic, which can be used as an alternative to crash records. The overall aim of this thesis is to explore which SMoS are suitable when analysing

Ett av Sveriges klimat- och energipolitiska mål avser effektivare energianvändning. Ett sätt att uppnå målet är genom kravställning på energihushållning vid renovering av byggnader. I de fall då det med hänsyn till byggnadens kultur- och arkitektoniska värde inte går att tillämpa beprövade metoder får andra alternativa metoder sökas. En sådan annan alternativ metod är en dubbelskalfasad och innebäOne of Sweden's political objective is to increase energy efficiency. One way to achieve the objective is by making demands on the use of energy after a building has been renovated. Regarding the building's cultural and architectural values there are cases where it is not possible to apply proven methods to meet the demands, and other alternative methods must be sought. Such an alternative

A trademark owner's exclusive right means a right to prevent others from using the protected trademark. However, the exclusive right only covers use in the course of trade in relation to goods or services. Trademark law contains only examples of which actions a trademark owner may object to. For this reason, the courts’ interpretation of the necessary conditions "use", "in relat

Purpose: The purpose is to improve the understanding of the process of applying blockchain technology in the financial services industry through information published by the most representative companies and institutions in the global landscape. Methodology: Qualitative research has been conducted through secondary data, which has been analyzed by employing thematic analysis. Theoretical perspec

The baobab is among the commonly consumed wild fruits found in the semi-arid regions of sub-Saharan Africa. It has a wide application in food systems and folk medicine and has an advantage of surviving even in harsh environmental conditions. While the fruit pulp is packed with a lot of essential nutrients and has gained much interest in recent past on the international market as a healthy ‘superfo