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Nitrogenase is the only enzyme that can cleave the strong triple bond in N2, making nitrogen available for biological lifeforms. The active site is a MoFe7S9C cluster (the FeMo cluster) that binds eight electrons and protons during one catalytic cycle, giving rise to eight intermediate states E0–E7. It is experimentally known that N2 binds to the E4 state and that H2 is a compulsory biproduct of t
Physics classrooms are still clearly marked by practices belonging to a certaineducational past, while teachers are increasingly being asked to teach in lignment with current equality, diversity and inclusion agendas. At the core of this temporal disconnect are teachers’ practices, which are strongly marked by normative regimes in terms of gender, race, ethnicity, class and other social factors. M
Background: Few longitudinal studies investigate predictors of substance use incidence among immigrants. The current study describes substance use disorders in immigrants to Sweden, focusing on drinking culture in the country of origin and socioeconomic status (SES), and how these intersect with generational status to influence risk. Methods: Using pseudonymized Swedish population registry data, w
Background Alcohol use disorder (AUD) is clinically heterogeneous. We examine its potential genetic heterogeneity as a function of sex, age, clinical features and mode of ascertainment. Methods In the Swedish population born 1932-1995 (n = 5 829 952), we examined the genetic risk profiles for AUD, major depression (MD), anxiety disorders, bipolar disorder, drug use disorder (DUD), attention defici
Accessible housing plays a crucial role in supporting aging in place, yet Japan lacks adequate tools for assessing housing accessibility among older adults. This study describes the process of translating and adapting the environmental component checklist of the Swedish Housing Enabler instrument for valid use in Japan. During translation to the Japanese language, technical terms and specification
Background: There is no consensus or clinical guidelines for screening routines of autoimmune disease in individuals with juvenile idiopathic arthritis (JIA), since results are conflicting whether the risk for such conditions is increased or not among individuals with JIA. The aim of this study was to investigate if the frequency of comorbid autoimmune conditions is increased after JIA diagnosis i
Ageing societies are facing major housing challenges. Understanding and addressing older adults' diverse housing needs and preferences are crucial. Having access to suitable and sustainable housing options can improve social cohesion, independence, health, and well-being. Participatory processes in housing development can enhance inclusion and democratic participation. This study uses Ramlösa Port
BACKGROUND: A large proportion of skeletal muscle insulin resistance in type 2 diabetes (T2D) is caused by environmental factors.METHODS: By applying multiomics mRNA, microRNA (miRNA), and DNA methylation platforms in biopsies from 20 monozygotic twin pairs discordant for T2D, we aimed to delineate the epigenetic and transcriptional machinery underlying non-genetic muscle insulin resistance in T2D
Introduction: No national recommendation for antibiotic prophylaxis for planned caesarean section in Sweden exists. Swedish delivery units have chosen different strategies. Some units routinely administer antibiotic prophylaxis to all women for whom a caesarean section is planned, while other units give prophylactic antibiotics to risk groups only. We took advantage of this “natural experiment” to
Background: Management of traumatic spinal cord injury is complex and depends on a multidisciplinary approach involving pre-hospital services, spinal surgery, intensive care unit treatment and specialized rehabilitation. International clinical practice guidelines for the handling of these patients offer specific recommendations regarding transportation, radiological investigations, timing of surge
Men with a low prostate-specific antigen (PSA) level (<1 ng/ml) in midlife may extend the rescreening interval (if aged 40–59 yr) or forgo future PSA screening (if aged >60 yr) owing to their low risk of aggressive prostate cancer (PCa). However, there is a subset of men who develop lethal PCa despite low baseline PSA. We investigated how a PCa polygenic risk score (PRS) in addition to baseline PS
The updated Consolidated Health Economics Evaluation Reporting Standards, CHEERS 2022, is considered the most comprehensive publication to assess reporting quality of economic evaluations (EEs) incorporating criteria of trial- and model-based studies, including emerging methods. However, it holds multiple criteria per item without clear decision rules on minimum requirements for complete reporting
Background: The optimal timing of pharmacological treatment for patent ductus arteriosus (PDA) in extremely pre-term infants is unknown. Objective: To investigate whether timing of pharmacological PDA treatment is associated with a risk of secondary PDA surgery or death before 3 months of age, or bronchopulmonary dysplasia (BPD) in extremely preterm infants. Methods: In this population-based cohor
Popular Abstract in Swedish Målet med kollektivtrafik är bl a att anordna transportförsörjning för alla samhällsgrupper på ett samhällsekonomiskt effektivt vis. En grupp medborgare är rullstolsburna resenärer, vars speciella förutsättningar ställer särskilda krav på transportsystemets utformning. För att utröna dessa speciella förutsättningar på ett ansvarsfullt sätt, är det viktigt att man anläggEliciting wheelchair-seated passengers’ perspective of safety and comfort is both useful and mandatory, particularly for researchers, clinicians, transit authorities, and for operators during purchase and use of vehicle technologies in existing and planned future transport systems. Therefore, the overarching objective of this thesis was to delineate the question of safety and comfort as perceived
BACKGROUND & AIMS: Few modifiable risk factors have been implicated in the etiology of pancreatic cancer. There is little evidence for the effects of caffeinated coffee, decaffeinated coffee, or tea intake on risk of pancreatic cancer. We investigated the association of total coffee, caffeinated coffee, decaffeinated coffee, and tea consumption with risk of pancreatic cancer. METHODS: This stu
An initial model in the crystallographic structure determination process, usually contains many errors. To produce an accurate model, one must carry out several cycles of crystallographic refinement. Because of the limited resolution typically obtained for biomolecules, the experimental data are usually supplemented by some sort of chemical information, typically in the form of a molecular-mechani
Defensive coping (DefS), oxidative stress, inflammation, and related amino acids (phenylalanine [Phe] and tyrosine [Tyr]) have been implicated in cardiovascular disease. This study assessed whether inflammation, oxidative stress, changes in essential amino acids, and altered coping strategies are correlated with subclinical vascular changes in African (n = 82) and Caucasian (n = 100) men from the
Objective: A pay for performance programme was introduced in 2009 by a Swedish county with 1.6 million inhabitants. A process measure with payment linked to coding for medication reviews among the elderly was adopted. We assessed the association with inappropriate medication for five years after baseline.Design and setting: Observational study that compared medication for elderly patients enrolled
