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Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this risk, we performed a genome-wide association study in 1,193 individuals with BRCA1 mutations who were diagnosed with invasive breast cancer under age 40 and 1,190 BRCA1 carriers without breast cancer diagnosis over age 35. We took forward 96 SNPs for replication in another 5,986 BRCA1 carriers (2,974 indivi
Popular Abstract in Swedish Syfte: Att undersöka den prediktiva precisionen hos ålder för missbruksdebut, MAO-B aktiviteten i blod, samt olika kombinationer av kriminologiska och kliniska riskfaktorer med avseende på återfall i våldsbrott hos tidigare våldsbrottsdömda i en prospektiv svensk uppföljningsstudie. Studiepopulation: Hundra våldsbrottslingar, konsekutivt intagna för rättspsykiatrisk undObjective: To test the predictive accuracy for violent recidivism of the age at onset of substance abuse, the platelet MAO-B activity, and various combinations of criminological and clinical risk factors among violent offenders in a prospective Swedish follow-up study. Subjects: One hundred violent offenders, consecutively admitted for forensic psychiatric investigations between 1998 and 2001 (bas
Objective: To analyse if predictors of radiographic progression differ between patients treated with or without prednisolone in early rheumatoid arthritis (RA). Radiographs of hands and feet were assessed using the modified Sharp/van der Heijde score and radiographic progression was defined as an increase in the total Sharp score above 5.8 (the smallest detectable change). Design: Prospective, ran
Background: Laryngo-pharyngeal reflux (LPR) is assumed to be the most common cause of posterior laryngitis (PL). Since LPR is found in healthy subjects, and PL patients are not improved by acid-reducing therapy, other aetiologies to PL must be considered. The aims of this study in PL were to investigate the prevalence of acid reflux in the proximal oesophagus and functional gastrointestinal sympto
Recent studies on young men from the general population have demonstrated geographic and ethnic differences in semen quality. The aim of this study was to investigate whether reported ethnic differences in semen quality might be associated with the maternally derived CAG and GGN polymorphisms in the androgen receptor gene or paternal ethnicity. In total 114 military conscripts from Latvia were inc
To be able to robustly propagate P. falciparum at optimal conditions in vitro is of fundamental importance for genotypic and phenotypic studies of both established and fresh clinical isolates. Cryo-preserved P. falciparum isolates from Ugandan children with severe or uncomplicated malaria were investigated for parasite phenotypes under different in vitro growth conditions or studied directly from
Background: Little is known of the association between thyroid hormones in the central nervous system and Alzheimer's disease (AD). We determined thyroid hormone levels in serum and cerebrospinal fluid (CSF) in a well-defined homogeneous mono-center population. Methods: Fifty-nine consecutive patients under primary evaluation for cognitive impairment were recruited. The participants included patie
Background. Islet allograft rejection in sensitized recipients is difficult to control by costimulation blockade using anti-CD154 and cytotoxic T-lymphocyte antigen-4 immunoglobulin (CTLA4Ig). Because leukocyte function antigen (LFA) 1 is highly expressed on memory T cells, adding an LFA-1 blockade may inhibit memory T-cell activities. We examined the effects on islet allograft survival of triple
Introduction: Apolipoprotein M (apoM) is present in 5% of high-density lipoprotein (HDL) particles in plasma. It is a carrier of sphingosine-1-phosphate (S1P), which is important for vascular barrier protection. The aim was to determine the plasma concentrations of apoM during sepsis and systemic inflammatory response syndrome (SIRS) and correlate them to levels of apolipoprotein A-I (apoA1), apol
The present study examined plasma lipoprotein, lipoprotein lipase, hepatic lipase, and insulin levels in men with borderline hypertension (diastolic blood pressure 85 to 94 mm Hg) compared with age-matched normotensive control subjects (diastolic blood pressure less than or equal to 80 mm Hg, n = 75 + 75). High-density lipoprotein (HDL) subclasses were determined in a subset (n = 45 + 45). While t
Dedicated clinics have been established for the early diagnosis and treatment of women at risk for inherited breast cancer, but the effects of such interventions are currently unproven. This second report on prospectively diagnosed inherited breast cancer from the European collaborating centres supports the previous conclusions and adds information on genetic heterogeneity and the effect of oophor
A new member of the human cystatin superfamily, called cystatin E, has been found by expressed sequence tag (EST) sequencing in amniotic cell and fetal skin epithelial cell cDNA libraries. The sequence of a full-length amniotic cell cDNA clone contained an open reading frame encoding a putative 28-residue signal peptide and a mature protein of 121 amino acids, including four cysteine residues and
This investigation determined the effects of fermented oat-based products containing both native and microbial beta-glucans on plasma lipids and on fecal total bacterial count and Bifidobacterium ssp. The study was randomized, double blind with 3 parallel groups. Sixty-two free-living volunteers with moderately increased plasma cholesterol levels were recruited. In the final analysis, 56 subjects
The DyDOC model simulates the C dynamics of forest soils, including the production and transport of dissolved organic matter (DOM), on the basis of soil hydrology, metabolic processes, and sorption reactions. The model recognizes three main pools of soil C: litter, substrate (an intermediate transformation product), and humic substances. The model was used to simulate the behavior of C in the 0 ho
Universitetslektor Kontaktinformation E-post: vladislava [dot] stoyanova [at] jur [dot] lu [dot] se Telefon: +46 46 222 11 51Organisation Juridiska institutionen Rumsnummer: 231 Hämtställe: 56 WebbplatsVladislava Stoyanovas profil i Lunds universitets forskningsportalAndra roller Forskare Mänskliga rättigheter Profilområdesmedlem LU profilområde: Mänskliga rättigheter Forskare Folkrätt Forskare EU
https://www.jur.lu.se/vladislava-stoyanova - 2026-07-04
Affilierad forskare Kontaktinformation E-post: jon [dot] bertilsson [at] fek [dot] lu [dot] se Telefon: +46 46 222 78 16Organisation Marknadsföring Rumsnummer: Alfa1:3062 Hämtställe: 10 WebbplatsJon Bertilssons profil i Lunds universitets forskningsportalAndra roller Affilierad forskare Centrum för handel och logistik (REAL) Docent Marknadsföring Publikationer Visar av publikationer. Sorterade eft
https://www.real.lu.se/jon-bertilsson - 2026-07-04
Affilierad forskare Kontaktinformation E-post: joakim [dot] kembro [at] tlog [dot] lth [dot] seOrganisation Teknisk logistik Besöksadress: Ole Römers väg 1, Rumsnummer: 5114 Hämtställe: 9 WebbplatsJoakim Kembros profil i Lunds universitets forskningsportalAndra roller Affilierad forskare Centrum för handel och logistik (REAL) Universitetslektor Teknisk logistik Publikationer Visar av publikationer
https://www.real.lu.se/joakim-kembro - 2026-07-04
BACKGROUND: Asthma may be defined either as wheeze within the previous 12 months (current wheeze) doctor-diagnosed asthma (DDA), or current wheeze plus confirmed airway hyperresponsiveness (AHR). AIMS: We wanted to estimate asthma prevalence in randomly selected adolescents based on different criteria for asthma diagnosis, study gender differences in reported asthma-like symptoms vs DDA, and relat
Purpose: To study the effect of inhaled corticosteroid (ICS) on bone mineral density (BMD) in an observational longitudinal study. Methods: In 1995-97, as part of the Nord-Trondelag Health Study, Norway, 10,941 subjects aged 20yr or more, either reporting asthma diagnosis/asthma-related symptoms or randomly selected, were interviewed, underwent spirometry and had their forearm BMD assessed. Among
