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We aimed to study the incidence, predictors, and outcome of chronic kidney disease (CKD) after heart transplantation (HT). All our HT patients 1988-2010 were considered for inclusion. Of these, 134 came for annual follow-ups including evaluation of glomerular filtration rate (GFR) using iohexol clearance measurements, and the CKD-EPI (adults) or Schwartz (children) formulae. Median GFR (Q1-Q3)(mL/
OBJECTIVES: To map out-patients with Chronic Obstructive Pulmonary Disease (COPD) with special reference to patients suffering from acute exacerbations, and to describe COPD health care structure and process in Swedish clinical practice in a real life setting. DESIGN: Retrospective, non-interventional, epidemiological survey. SETTING: 141 hospital based out patient clinics (OPC, n=30) and primary
Aims: The Swedish National Inpatient Registry is an important source of data for numerous epidemiological studies, amongst them studies on chronic obstructive pulmonary disease (COPD). General validation studies indicate that in general 85-95% of diagnoses reported are correct, but this is not true for all groups of diseases, why specific validation studies are of great importance. Methods: Charts
OBJECTIVE: This study examined the relationship between leukocyte telomere length (LTL), a marker of cell aging, and psychiatric disorders in adults compared with controls using meta-analytic methods. METHODS: Data were abstracted from studies examining the relationship between LTL and adult psychiatric disorders. In addition to an overall estimate of effect size, subgroup analyses and meta-regres
In the twelfth century the Norbertine order was introduced in parts of Scandinavia. One initiator in the north was Eskil, the powerful archbishop of Lund. However, in the beginning of the thirteenth century the mendicant orders were introduced by successors to the archbishopric. This led to a general decline of other orders. In spite of that the Norbertines managed to prosper in Bäckaskog, an abbeIn the twelfth century the Norbertine order was introduced in parts of Scandinavia. One initiator in the north was Eskil, the powerful archbishop of Lund. However, in the beginning of the thirteenth century the mendicant orders were introduced by successors to the archbishopric. This led to a general decline of other orders. In spite of that the Norbertines managed to prosper in Bäckaskog, an abbe
Purpose To explore the association of baseline trabecular bone structure with incident tibiofemoral (TF) osteoarthritis (OA) and with increase in joint space narrowing (JSN) score. Methods The Multicenter Osteoarthritis Study (MOST) includes subjects with or at risk for knee OA. Knee radiographs were scored for Kellgren–Lawrence (KL) grade and JSN at baseline, 30, 60 and 84 months. Knees (KL ≤ 1)
Previous studies have suggested that a high intake of sugar-sweetened beverages is positively associated with the risk of a coronary event. However, a few studies have examined the association between sucrose (the most common extrinsic sugar in Sweden) and incident coronary events. The objective of the present study was to examine the associations between sucrose intake and coronary event risk and
Context: We have previously found that visceral fat is a stronger predictor for cardiovascular risk factors than body mass index (BMI). Objective: This study sought to investigate the prevalence of diabetes in elderly men and women in relation to objectively assessed visceral fat volume. Design and Setting: The cohort consisted of a population-based sample of 705 men and 688 women, all age 70 y at
Objective: Adipocyte hypertrophy has been suggested to be causally linked with inflammation and systemic insulin resistance. The aim of the study was to determine whether increased adipocyte size is associated with increased liver fat content due to nonalcoholic fatty liver disease (NAFLD) in humans independent of obesity, fat distribution and genetic variation in the patatin-like phospholipase do
Research article 2928 The Journal of Clinical Investigation http://www.jci.org Volume 122 Number 8 August 2012 Identification of embryonic stem cell–derived midbrain dopaminergic neurons for engraftment Yosif M. Ganat,1,2,3 Elizabeth L. Calder,1,2,3 Sonja Kriks,1,2 Jenny Nelander,4 Edmund Y. Tu,1,2,5 Fan Jia,6 Daniela Battista,1,7 Neil Harrison,6 Malin Parmar,4 Mark J. Tomishima,1,2,5
https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/jci58767.pdf - 2026-07-25
Background: The thorough assessment of familial prostate cancer (PCa) risk is as important as ever to provide a basis for clinical counselling and screening recommendations. Objective: Our aim was to determine the age-specific risks of PCa and the risk of death from PCa according to the number and the age of affected first-degree relatives. Design, setting, and participants: The nationwide Swedish
Att jag intresserar mig för stranden som plats för mitt examensarbete är kanske inte så konstigt. Som vågsurfare har jag tillbringat mycket tid på stranden och ute bland vågorna. Genom surfingen har jag upplevt många olika kuststräckor och vågor på jorden, men just stranden och surfingen i Sverige har fångat mitt intresse. Här är årstidernas förändringar och havets stormar de största utmaningarna,It is not that surprising that I chose the beach as the subject of my thesis. As a surfer, I have spent a lot of time on the beach and among the waves. Through surfing I have experienced a wide variety of coastlines around the world, but the beaches of Sweden have peaked my interest. The changing of the seasons and the ocean´s storms are the biggest challenges here for a surfer, not the size of th
The chaperone DNAJB6b (JB6) plays important roles in increasing amyloid protein solubility and inhibiting amyloid fibril formation, a causative factor for neurodegenerative diseases like Alzheimer's and Parkinson's disease. Insights into the biophysical properties of JB6, including its structure, self-assembly and stability towards denaturation, may enhance the understanding of the physicochemical
Testing models of macroevolution, and especially the sufficiency of microevolutionary processes, requires good collaboration between molecular biologists and paleontologists. We report such a test for events around the Late Cretaceous by describing the earliest penguin fossils, analyzing complete mitochondrial genomes from an albatross, a petrel, and a loon, and describe the gradual decline of pte
The aim of this thesis was to study annually laminated (varved) Holocene lake sediment in Sweden, their formation and their potential as chronological and palaeoecological archives. Five lakes with continuous Holocene varved lake sediment sequences in northern (Västerbotten) and west central Sweden (Värmland) were investigated. Three of these sequences were discovered during this study, which iden
Objective. To examine the appropriateness and necessity of colonoscopy across Europe. Design. Prospective observational study. Setting. A total of 21 gastrointestinal centers from 11 countries. Participants. Consecutive patients referred for colonoscopy at each center. Intervention. Appropriateness criteria developed by the European Panel on the Appropriateness of Gastrointestinal Endoscopy, u
Background Breathlessness is associated with major adverse health outcomes and is twice as common in women as men in the general population. We evaluated whether this is related to their lower absolute lung volumes. Methods Cross-sectional analysis of the population-based Swedish CardioPulmonarybioImage Study (SCAPIS) Pilot, including static spirometry and diffusing capacity (n = 1,013; 49% women)
