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Det finns runt 100 000 blinda och kraftigt synnedsatta individer (BKSI:er) i Sverige. Sådan synnedsättning leder till en kraftigt minskad förmåga för självständig förflyttning och lägre livskvalité, med ökad risk för arbetslöshet, trafikolyckor, en stillasittande livsstil och depression. Hälften av alla käpp- och hundanvändare är med om en huvudkollision årligen, och drygt var tredje för en fallolReduced independent mobility of blind and low-vision individuals (BLVIs) cause considerable societal cost, burden on relatives, and reduced quality of life for the individuals, including increased anxiety, depression symptoms, need of assistance, risk of falls, and mortality. Despite the numerous electronic travel aids proposed since at least the 1940’s, along with ever-advancing technology, the m

Background: Women with breast cancer have different chances of surviving their disease, depending on where they live. Variations in survival may stem from unequal access to prompt diagnosis, treatment and care. Implementation of the right to health may help remedy such inequalities. The right to health is enshrined in international human rights law, notably Article 12 of the International Covenant

Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity. It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority of SCLCs exhibit neuroendocrine features, an important subset of tumors lacks these properties. Genomic profiling of SCLC reveals genetic instability, almost universal inactivation of the tumor suppressor genes TP5

Background and aims: Several different scoring systems for early risk stratification after out-of-hospital cardiac arrest have been developed, but few have been validated in large datasets. The aim of the present study was to compare the well-validated Out-of-hospital Cardiac Arrest (OHCA) and Cardiac Arrest Hospital Prognosis (CAHP)-scores to the less complex MIRACLE2- and Target Temperature Mana

Health information system (HIS) refers to a data collection and management system that supports the use of health information for planning, management and decision making. Robust HISs are required for the proper management of health data to produce and share high-quality health information for informing planning and decision making at different levels of the health system. This chapter presents th

Traumatic brain injury (TBI) or repeated sport-related concussions (rSRC) may lead to long-term memory impairment. Diffusion tensor imaging (DTI) is helpful to reveal global white matter damage but may underestimate focal abnormalities. We investigated the distribution of postinjury regional white matter changes after TBI and rSRC. Six patients with moderate/severe TBI, and 12 athletes with rSRC w

Background: The early management of polytrauma patients with traumatic spinal cord injury (tSCI) is a major challenge. Sparse data is available to provide optimal care in this scenario and worldwide variability in clinical practice has been documented in recent studies. Methods: A multidisciplinary consensus panel of physicians selected for their established clinical and scientific expertise in th

This is a study of a Soviet espionage mission in Sweden in 1942 under the aegis of the intelligence officer Vasilii Sidorenko. Aside from trying to reconstruct, on the basis of material filed with the archive of the Swedish Security Police (Säpo), the history of the mission, the article also addresses methodological challenges following from the fact that we must, as Soviet material remains very sThis is a study of a Soviet espionage mission in Sweden in 1942 under the aegis of the intelligence officer Vasilii Sidorenko. Aside from trying to reconstruct, on the basis of material filed with the archive of the Swedish Security Police (Säpo), the history of the mission, the article also addresses methodological challenges following from the fact that we must, as Soviet material remains very s

Syftet med rapporten är att översiktligt analysera om alternativa organisations- och finansieringsformer, som är möjliga att tillämpa inom ramen för svensk lagstiftning, kan ge större nytta i termer av högre kostnadseffektivitet, snabbare genomförande och mindre eftersatt underhåll än traditionella offentliga upplägg, inom området transportinfrastruktur. Studien avgränsas till den transportinfrast

This study investigates the publication and reception of the Latin American boom literature in Sweden from 1960 to 1990, focusing on Julio Cortázar, Carlos Fuentes, Gabriel García Márquez and Mario Vargas Llosa. It analyses the extent of Swedish translations of their works and the type and amount of attention they received in the Swedish press. Using a bibliometric approach for the translations, a

Context: Medications may become inappropriate for patients in the last phase of life and may even compromise their quality of life. Objective: To find consensus on recommendations regarding deprescribing of medications for adult patients with a life expectancy of six months or less. Methods: Experts working in palliative care or other relevant disciplines were asked to participate in this internat

The main goal of this thesis has been to investigate the interaction of the intrinsically disordered peptide Histatin 5 (Hst5), with phospholipid bilayers, using a mixture of experimental and computational techniques, such as, small- angle X-ray scattering, circular dichroism, neutron reflectometry, quartz-crystal microbalance with dissipation monitoring, atomistic molecular dynamics simulations, The main goal of this thesis has been to investigate the interaction of the intrinsically disordered peptide Histatin 5 (Hst5), with phospholipid bilayers, using a mixture of experimental and computational techniques, such as, small- angle X-ray scattering, circular dichroism, neutron reflectometry, quartz-crystal microbalance with dissipation monitoring, atomistic molecular dynamics simulations,

BACKGROUND: To strengthen palliative care for children in the Nordic countries, an updated status of current needs, resources, clinical services, education, and research is necessary to align and consolidate future research. A Nordic research collaboration initiative for children with palliative care needs was assembled in 2023. Building on this initiative, this paper presents an overview of pedia

Concussion, caused by a rotational acceleration/deceleration injury mild enough to avoid structural brain damage, is insufficiently captured in recent preclinical models, hampering the relation of pathophysiological findings on the cellular level to functional and behavioral deficits. We here describe a novel model of unrestrained, single vs. repetitive concussive brain injury (CBI) in male C56Bl/

In the dawning era of artificial intelligence (AI), health care stands to undergo a significant transformation with the increasing digitalization of patient data. Digital imaging, in particular, will serve as an important platform for AI to aid decision making and diagnostics. A growing number of studies demonstrate the potential of automatic pre-surgical skin tumor delineation, which could have t

Every Sunday, sermons are delivered in over a thousand churches within the Church of Sweden. In each of them, theology is not just applied but also ”done”, or formulated. Using the concept of “theologizing” and building on theories from two professors in homiletics, David Schnasa Jacobsen and Leonora Tubbs Tisdale, this thesis empirically investigates in what ways preachers in the Lutheran Church

Objective: To examine associations between body mass index (BMI) in early pregnancy and gestational weight gain (GWG) with cardiovascular health in middle age using the ‘Life's Essential 8’ (LE8) concept of the American Heart Association (AHA). Design: Population-based cohort study. Setting: Swedish CardioPulmonary bioImage Study (SCAPIS). Population: A total of 8871 women from SCAPIS were include

Situated in the intersection of the literature on QoL and lifestyle migration, this paper contributes to the discussion of three subjective components of QoL after migrating to another country. These are hedonic (happiness), evaluative (life satisfaction) and eudaimonic (having a purposeful or worthwhile life). Based on 36 in-depth interviews to Swedish citizens permanently living in Portugal, a g