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Co-presentation with both ANCA and anti-GBM antibodies is thought to be relatively rare. Current studies of such 'double-positive' cases report small numbers and variable outcomes. To study this further we retrospectively analyzed clinical features and long-term outcomes of a large cohort of 568 contemporary patients with ANCA-associated vasculitis, 41 patients with anti-GBM disease, and 37 double
Linkage between behavioral states and neural activity is one of the most important challenges in neuroscience. The network activity patterns in the awake resting state and in the actively behaving state in rodents are not well understood, and a better tool for differentiating these states can provide insights on healthy brain functions and its alteration with disease. Therefore, we simultaneously
The microstructure of calcite in the CM2 carbonaceous chondrite LON 94101 has been characterized using electron backscatter diffraction (EBSD) analysis, to reconstruct the parent body deformation history during and/or after aqueous alteration. The results suggest that at least two events of calcite crystallization have taken place during aqueous alteration, and at least three episodes of deformati
Communities all over the world are using traditional technologies to extract drinkingwater, irrigate their lands and feed their livestock. But these often sustainable and ancient ways to make use of groundwater are in rapid decline worldwide. A research project started in 1999 to study the rehabilitation of 1500-year old water tunnels called "qanats"in Syria. To Cooperate or not to Cooperate...? d
The Ordovician Lockne impact structure is located in central Sweden. The target lithology consisted of limestone and black unconsolidated shale overlaying a Precambrian crystalline basement. The Precambrian basement is uranium-rich, and the black shale is both uranium- and organic-rich. This circumstance makes Lockne a good candidate for testing the occurrence of U-Th-rich bitumen nodules in an im
A search for heavy long-lived charged R-hadrons is reported using a data sample corresponding to 3.2 fb−1 of proton–proton collisions at s=13 TeV collected by the ATLAS experiment at the Large Hadron Collider at CERN. The search is based on observables related to large ionisation losses and slow propagation velocities, which are signatures of heavy charged particles travelling significantly slower
Purified and membrane-bound succinate dehydrogenase (SDH) from bovine heart mitochondria was inhibited by the histidine-modifying reagents ethoxyformic anhydride (EFA) and Rose Bengal in the presence of light. Succinate and competitive inhibitors protected against inhibition, and decreased the number of histidyl residues modified by EFA. The essential residue modified by EFA was not the essential
Objective: The objective of this study was to assess the resource use of treating overactive bladder (OAB) patients in real-world clinical practice and to evaluate whether there is external validity in the treatment of OAB in clinical practice. Materials and methods: The study included 55 patients suffering from OAB and treated with BOTOX® at two Swedish clinics. The study was conducted as an anon
While prior studies have largely addressed corporate social responsibility (CSR) at a macro or institutional level, its importance at the micro or individual level is to date underexplored, especially in the context of developing economies. Further, it is not clear from the studies in the extant literature how the role of females is more important in the context of environmental management as comp
Differential cross-section measurements are presented for the electroweak production of two jets in association with a Z boson. These measurements are sensitive to the vector-boson fusion production mechanism and provide a fundamental test of the gauge structure of the Standard Model. The analysis is performed using proton–proton collision data collected by ATLAS at s=13TeV and with an integrated
The minimization of a functional composed of a nonsmooth and nonadditive regularization term and a combined L1 and L2 data-fidelity term is proposed. It is shown analytically and numerically that the new model has noticeable advantages over popular models in image processing tasks. For the numerical minimization of the new objective, subspace correction methods are introduced which guarantee the c
Purpose: Most studies on paediatric pharyngotonsillitis focus on group A streptococci. This study, however, analyses a broad spectrum of bacteria and viruses related to paediatric pharyngotonsillitis and evaluates their associated clinical symptoms and courses. Methods: This observational prospective study in primary healthcare includes 77 children aged < 15 with a sore throat and 34 asymptomatic
Direct ground cooling is a method for cooling buildings whereby free cooling is provided by circulating water through borehole heat exchangers (BHEs). Since no refrigeration cooling is involved, supply water temperature to the building's cooling system is dependent mainly on BHE sizing. This study investigates the sizing of BHEs for direct ground cooling systems, with a particular focus on the inf
Denna avhandling utforskar den meta-etiska frågan: Vilka egenskaper krävs av ett normativt kritiskt begrepp så att det både kan (a) härledas från den sociala faktiska verkligheten av gällande normer, praktiker och institutioner i ett givet samhälle och (b) vara utgångpunkt för radikal kritik? Radikal kritik förstås i avhandlingen som en kritik bortom anklagelser om partiskhet gentemot det rådandeThis thesis explores the meta-ethical question: What properties would be required of a normative critical concept in order for it to be (a) derived from the social facticity of prevailing norms, practices and institutions in a given society and (b) still be capable of informing radical critique? This thesis takes radical critique to mean one that escapes all charges of status quo biases and thus t
This case study investigates the potentials, greenhouse gas (GHG), and energy performance of forest residue biofuels produced by new and emerging production technologies, which are commercially implemented in Sweden for heavy transport. The biofuel options included are ethanol (ED 95), hydro-processed vegetable oil (HVO), and liquefied biogas (LBG) produced from logging residues in forestry and sa
Introduction: The role of chemotherapy for patients with dedifferentiated chondrosarcoma (DDCS) is still under discussion. Here, we present the outcome in patients with DDCS treated with intensive chemotherapy from the EUROpean Bone Over 40 Sarcoma Study. Materials and methods: The chemotherapy regimen included doxorubicin, ifosfamide and cisplatin. Postoperative methotrexate was added in case of
Growth and hydrogen production by two extreme thermophiles during sugar fermentation was investigated. In cultures of Caldicellulosiruptor saccharolyticus grown on sucrose and Thermotoga elfii grown on glucose stoichiometries of 3.3 mol of hydrogen and 2 mol of acetate per mol C6-sugar unit were obtained. The hydrogen level was about 83% of the theoretical maximum. C. saccharolyticus and T. elfi
In this paper, a novel membrane reactor (MR) for methanol steam reforming is modeled to produce fuel cell grade hydrogen, which can be used as the inlet fuel for a later developed 500-W horizon polymer electrolyte fuel cell (PEFC) stack. The backpropagation (BP) neural network algorithm is employed to develop the mapping relation model between the MR's prime operational parameters and fuel cell ou
