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B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) is the most common childhood malignancy and is driven by multiple genetic alterations that cause maturation arrest and accumulation of abnormal progenitor B cells. Current treatment protocols with chemotherapy have led to favorable outcomes but are associated with significant toxicity and risk of side effects, highlighting the necessity for

Introduction Parkinson’s disease (PD) is a common neurodegenerative disease, which has extensive pathology that critically includes the loss of midbrain dopaminergic neurons. This loss leads to debilitating motor features such as bradykinesia and rigidity, as well as some non-motor symptoms. Intracerebral dopamine cell transplants have been explored for many years as a new approach to treating PD

The reassignment technique is used to increase localization for signal components in the time-frequency representation. The technique gives perfect localization for linear chirp signals and constant frequency signals. Despite the recent interest in using the reassignment technique to determine phase-shifts, no general expression of cross-spectrogram reassignment vectors exists. This submission aim

Banverket äger och förvaltar ett stort antal tunnlar samtidigt som planering och byggande pågår för ett flertal tunnlar. Syftet med föreliggande arbete är att öka kunskapen och på sikt förbättra och förenkla processen angående personsäkerhet i tunnlar. Rapporten beskriver det inventeringsarbete som utförts med avseende på både befintliga och nya tunnlar med fokus på personsäkerhet...

BACKGROUND: There is little consensus on a standard approach to analysing bone scan images. The Bone Scan Index (BSI) is predictive of survival in patients with progressive prostate cancer (PCa), but the popularity of this metric is hampered by the tedium of the manual calculation. OBJECTIVE: Develop a fully automated method of quantifying the BSI and determining the clinical value of automated

The second phase of the Fifth International Ice Nucleation Workshop (FIN-02) involved the gathering of a large number of researchers at the Karlsruhe Institute of Technology's Aerosol Interactions and Dynamics of the Atmosphere (AIDA) facility to promote characterization and understanding of ice nucleation measurements made by a variety of methods used worldwide. Compared to the previous workshop

Artikeln återger författarens föreläsning vid installationen som professor i offentlig rätt vid juridiska fakulteten vid Lunds universitet i oktober 2018. Föreläsningen uppmärksammar de indelningar och specialiseringar som förekommer i juridiken,och då särskild offentlig rätt. Avsikten är att uppmärksamma frågan varför man överhuvudtaget ska tala om offentlig rätt och varför man ska ägna sig åt de

The genetic mechanisms underlying the expansion in size and complexity of the human brain remain poorly understood. Long interspersed nuclear element-1 (L1) retrotransposons are a source of divergent genetic information in hominoid genomes, but their importance in physiological functions and their contribution to human brain evolution are largely unknown. Using multiomics profiling, we here demons

Acute myeloid leukemia (AML) is initiated and propagated by leukemia stem cells (LSCs), a self-renewing population of leukemia cells responsible for therapy resistance. Hence, there is an urgent need to identify new therapeutic opportunities targeting LSCs. Here, we performed an in vivo CRISPR knockout screen to identify potential therapeutic targets by interrogating cell surface dependencies of L

Företag marknadsför över 200 mjukvaror för artificiell intelligens (AI) inom radiologi.Vårdgivare behöver ha möjlighet till opartisk och kvalitetssäkrad utvärdering.Projektet Validering av AI inom bröst­radio­­­logi (VAI-B) startades för att möta detta behov, initialt inom mammografi­screening.

Homeowners are facing worse personal finances with high inflation and increasing interest rates. New groups are at risk of overindebtedness and foreclosure. The entire household, including children, are affected by worse health and well-being. This leads to large societal costs. Hence, it is imperative to break the negative cycle of overindebtedness for these households. Foreclosure is enforced by

A significant problem in diffusion MRI (dMRI) is the lack of understanding regarding which microstructural features account for the variability in the diffusion tensor imaging (DTI) parameters observed in meningioma tumors. A common assumption is that mean diffusivity (MD) and fractional anisotropy (FA) from DTI are inversely proportional to cell density and proportional to tissue anisotropy, resp

As a major buyer of steel, the construction sector is uniquely positioned to advance the decarbonization of global steel through increasing the demand for green steel. To unlock this potential, deepened international collaborations on green public procurement, climate policies, and trade are needed.

I denna uppsats undersöks aborträtten i Sverige och Irland samt innebörden av artiklarna 2, 3, 8, 9 och 10 i Europakonventionen i förhållande till aborter. Syftet är att belysa övergripande likheter och skillnader mellan de svenska och de irländska reglerna och att diskutera hur de nationella reglerna kan förändras, för att stärka olika rättigheter och bättre harmoniera med Europakonventionen. DetThis essay investigates abortion law in Sweden and Ireland and the meaning of articles 2, 3, 8, 9 and 10 of the European Convention on Human Rights, in relation to abortions. The aim is to illustrate general similarities and differences between Swedish and Irish abortion law and to discuss how the law might be changed in order to strengthen different rights and to increase its harmonisation with t

Retail as unusual RETAILING IN A TIME OF EXTREME UNCERTAINTY Edited by: Carys Egan-Wyer Ulf Johansson Martin Moström 2 RETAIL AS UNUSUAL Retail as unusual RETAILING IN A TIME OF EXTREME UNCERTAINTY EDITED BY: CARYS EGAN-WYER ULF JOHANSSON MARTIN MOSTRÖM 3 RETAIL AS UNUSUAL Table of contents Retail as unusual . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

https://www.ehl.lu.se/sites/ehl.lu.se/files/2024-03/Retail%20as%20unusual%20-%20final%20web.pdf - 2026-05-22