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Pleiotropic Effects of GIP on Islet Function Involve Osteopontin

OBJECTIVE-The incretin hormone GIP (glucose-dependent insulinotropic polypeptide) promotes pancreatic beta-cell function by potentiating insulin secretion and beta-cell proliferation. Recently, a combined analysis of several genome-wide association studies (Meta-analysis of Glucose and Insulin-Related Traits Consortium [MAGIC]) showed association to postprandial insulin at the GIP receptor (GIPR)

Exploatering av förorenade fastigheter - En studie av fördelning av ansvar, kostnader och risk

Centrala lägen av städerna vilka tidigare nyttjats för industri har genom ett förändrande samhälle och ekonomi kommit att lämnats orörda och i förfall. Detta medför att det idag finns attraktiva fastigheter med potentiella föroreningar i mark och byggnader vilka samhället nu önskar utnyttja för andra ändamål såsom bostäder, kontor och handel. Exploatering av dessa områden innebär stora kostnader oAttractive locations in cities, previously used for industry, have been left untouched and in disrepair due to changes in society and the economy. This situation has resulted in central properties with potentially contaminated land and buildings that society now wishes to redevelop for housing, offices and commerce. Developing these areas involves significant costs and uncertainties for potential

Utvecklingen av skadeståndssanktionen i EU:s konkurrensrätt – no guts no glory

Trots tydlig rättspraxis och en stark politisk vilja att säkra rätten för varje enskild eller företag som lidit skada vid brott mot EU:s konkurrensregler – i synnerhet artiklarna 101 och 102 Fördraget om Europeiska unionens funktionssätt (EUF) - att kunna söka kompensation, så har det konkurrensrättsliga skadeståndet inte fått något större genomslag. Europakommissionen (”Kommissionen”) har med andDespite the clear view of the European Commission (“the Commission”) and the European Court of Justice (“the ECJ”) that any citizen or business suffering harm following a breach of the EU competition rules - in particular Articles 101 and 102 of the Treaty of the Functioning of the European Market (TFEU) - should be able to obtain damages from the infringing party, to this date, damages have only

The evolution of lepidopteran brain morphology

Animals live in diverse environments and have evolved to cope with environmental challenges in different ways. How such adaptations shape overall brain morphology is still unclear. Here, we test how two behavioural adaptations – circadian activity pattern and migratory behaviour – are reflected in the brains of moths and butterflies (Lepidoptera). We predicted that circadian activity pattern affec

Abstract P4-09-03: On the development and clinical value of RNA-sequencing-based classifiers for prediction of the five conventional breast cancer biomarkers: A report from the population-based multicenter SCAN-B study

Background:In early breast cancer, five histopathological biomarkers are part of current clinical routines and used for determining prognosis and treatment: estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (ERBB2/HER2), Ki67, and Nottingham histological grade (NHG). We aimed to develop classifiers for these biomarkers based on tumor mRNA-sequencing (RNA

High Levels of Soluble Lectinlike Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Carotid Plaque Inflammation and Increased Risk of Ischemic Stroke

Background When the lectinlike oxidized low-density lipoprotein (ox LDL) receptor-1 ( LOX -1), a scavenger receptor for ox LDL , binds ox LDL , processes leading to endothelial dysfunction and inflammation are promoted. We aimed to study release mechanisms of LOX -1 and how circulating levels of soluble LOX -1 ( sLOX -1) relate to plaque inflammation and future risk for ischemic stroke. Methods an

Increased pulmonary blood volume variation in patients with heart failure compared to healthy controls; a non-invasive, quantitative measure of heart failure

Variation of the blood content of the pulmonary vascular bed during a heartbeat can be quantified by pulmonary blood volume variation (PBVV) using magnetic resonance imaging (MRI). The aim was to evaluate if PBVV differs in patients with heart failure compared to healthy controls and investigate the mechanisms behind the PBVV. Forty-six patients and 10 controls underwent MRI. PBVV was calculated f

Cryo-EM structure supports a role of AQP7 as a junction protein

Aquaglyceroporin 7 (AQP7) facilitates glycerol flux across the plasma membrane with a critical physiological role linked to metabolism, obesity, and associated diseases. Here, we present the single-particle cryo-EM structure of AQP7 determined at 2.55 Å resolution adopting two adhering tetramers, stabilized by extracellularly exposed loops, in a configuration like that of the well-characterized in

Corona-pandemins kaskadeffekter på lokal och regional nivå med avseende på samhällsviktiga funktioner : Mot ökad motståndskraft

Rapporten fokuserar på hur Covid-19 har påverkat olika samhällsviktiga verksamheter i Skåne. Verksamheterna har påverkats mycket, men det har inte uppstått allvarliga funktionsstörningar. Undantagen är Hälso- och sjukvård samt omsorg, och Transportsektorn där även funktionspåverkan förekommit I rapporten analyseras även hur förberedelser har skett och vilka lärdomar som kan dras av Covid-19.

Pharmacometabolomic Profiling Of The General Population: Relation Of Active Metabolite Levels To Cardiovascular Risk Factor Control And Manifest Atherosclerosis

Introduction: The use of medications in the general population has increased over time. Information on active metabolite concentrations for common drugs in the general population is limited. Recent advances in metabolomic technologies have made high-throughput profiling of many active metabolites in large epidemiological cohorts increasingly feasible.Aim: 1. Prospective assessment of the proportio

A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development

The human forebrain has expanded in size and complexity compared to chimpanzees despite limited changes in protein-coding genes, suggesting that gene expression regulation is an important driver of brain evolution. Here, we identify a KRAB-ZFP transcription factor, ZNF558, that is expressed in human but not chimpanzee forebrain neural progenitor cells. ZNF558 evolved as a suppressor of LINE-1 tran

Multinodal Acoustic Trapping Enables High Capacity and High Throughput Enrichment of Extracellular Vesicles and Microparticles in miRNA and MS Proteomics Studies

We report a new design of an acoustophoretic trapping device with significantly increased capacity and throughput, compared to current commercial acoustic trapping systems. Acoustic trapping enables nanoparticle and extracellular vesicle (EV) enrichment without ultracentrifugation. Current commercial acoustic trapping technology uses an acoustic single-node resonance and typically operates at flow

Lokalforsorjningsplan 2021

Lokalförsörjningsplan 2021 Lokalförsörjningsplan 2021 LUNDS UNIVERSITET FÖRORD .................................................................................... 5 1. LOKALFÖRSÖRJNING VID LUNDS UNIVERSITET ................6 1.1 Mål för Lunds universitets campus och lokaler ................7 1.2 Campusutveckling .......................................................... 8 1.3 Principer för lokalf

https://www.staff.lu.se/sites/staff.lu.se/files/2021-01/Lokalforsorjningsplan_2021.pdf - 2026-05-16

Cfewp16

Namnl.st-1 1Tales of Ambivalence Tales of Ambivalence Stories of Acceptance and Rejection among Swedish Expatriates in Poland David Wästerfors david.wasterfors@soc.lu.se 3Tales of Ambivalence2 CFE Working paper series no. 16 CENTRE FOR EUROPEAN STUDIES AT LUND UNIVERSITY: Box 52 Phone: +46 (0)46-222 88 99 SE-221 00 LUND Fax: +46 (0)46-222 40 06 Sweden Email: cfe@cfe.lu.se CFE Working paper series

https://www.cfe.lu.se/en/sites/cfe.lu.se.en/files/2020-12/cfewp16.pdf - 2026-05-16

No title

Master’s Dissertation Structural Mechanics CARL LÖFQUIST RESPONSE OF BUILDINGS EXPOSED TO BLAST LOAD Method Evaluation DEPARTMENT OF CONSTRUCTION SCIENCES STRUCTURAL MECHANICS ISRN LUTVDG/TVSM--16/5216--SE (1-88) | ISSN 0281-6679 MASTER’S DISSERTATION Supervisor: Professor PER-ERIK AUSTRELL, Div. of Structural Mechanics, LTH. Examiner: Professor KENT PERSSON, Div. of Structural Mechanics, LTH. Cop

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5216.pdf - 2026-05-16