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Characterization of gene expression in pancreatic islets and its alteration in type 2 diabetes (T2D) are vital in understanding islet function and T2D pathogenesis. We leveraged RNA sequencing and genome-wide genotyping in islets from 188 donors to create the Islet Gene View (IGW) platform to make this information easily accessible to the scientific community. Expression data were related to islet
This thesis consists of two parts, applying concepts from automatic control to different application areas.The first part of this thesis concerns the development of an optimization-based algorithm, determining the size of insulin and glucose doses for patients suffering from Diabetes Mellitus and treated with multiple insulin injections. Diabetes Mellitus is a chronic disease characterized by elev
A literature review and statistical analysis of the potential of agricultural residual waste as building materials in South Sweden was carried out. This data showed that there is a clear capacity for the use of mainly straw-generating crops as building materials in the region.
Vid gravområdet Ormknös på Björkö hittades under 1970-talet en drejad kanna med hank i en av gravarna. Den kan nu bestämmas till en produktion inom khazariskt område vid Azovska sjön. En abbasidisk dirhem funnen i graven anger en nedläggning till 800-talets mitt eller strax därefter. Kannan av tamatarchatyp är ovanlig utanför produktionsområdet. Den anknyter till de östfärder som utgör ett tidigt
Realtidsövning för lärande i sammanhang är en övning i ett verklighetstroget scenario där studenterna tar beslut och agerar i realtid, samt systematiskt reflekterar över dessa beslut och handlingar. Det är detta systematiska och lärarledda växelspel mellan självständigt agerande och reflektion som är realtidsövningens viktigaste särdrag. Denna övningsform kan vara ett värdefullt verktyg i akademis
Electrostatic interactions in bio-molecular systems are important not only in the living cell but also in more technical applications. Using molecular simulation as well as approximate theories the properties of a number of aqueous protein solutions have been studied. This includes interactions with other proteins, protons, charged membranes as well as flexible polyelectrolytes. The focus is on el
This thesis includes two different parts: One focusing on how to induce human embryonic stem cells (hESCs) to differentiate into insulin producing cells by following the normal pancreatic development pathway. These cells have then the potential to be an unlimited source for diabetes regenerative medicine. The second part of the thesis deals with how embryonic stem cells rid themselves of damaged p
I have in this thesis been trying to answer the question of how a state legitimately can punish their citizens. I am of the opinion that this kind of discussion is needed in a state governed by law. I have gathered information by reading a number of renowned philosophers and jurists. I have accounted for their view of punishment and the foundation on which the society is legitimated. To that, I ha
Introduction: Dental caries among preschool children is a global problem, a burden on children’s well-being, and an economic burden on healthcare systems. In Sweden, preschool children with an immigrant background have a higher prevalence of caries. Extensive treatment need and long-standing poor oral health may require dental treatment within hospital care. This study aimed to investigate whether
In this project, morphological differences between motion detector neurons in Drosophila melanogaster were compared and used to speculate regarding their function. This was achieved by comparing properties such as diameter, height, width, bifurcation, asymmetry and terminal degree. To assist in the comparison, neurons were also visualized in 3D to identify structural differences. It was found that
Det finns önskemål från kommunens sida att öka det kommunala engagemanget hos medborgare i allmänhet och hos yngre medborgare i synnerhet. Detta kan vara allt från att engagera sig i upprättandet av en staty, till att anmäla en nedbrunnen grillplats. Datakonsultföretaget Abou AB har i samråd med vissa kommuner kommit fram till att en mobil applikation kan vara en möjlig kanal när det kommer till aThere is a desire by the municipalities to increase local involvement of citizens in general and of young citizens in particular. Computer consultancy firm Abou AB, in consultation with some of the municipalities, has concluded that a mobile application can be a possible channel when it comes to increasing the municipal engagement. Examples may be ranging from engagement in the question of whether
Extant research within the entrepreneurial marketing field has typically focused on the migration away from traditional marketing concepts while mostly ignoring the inclusion of branding as a fundamental principle of marketing. This paper is specifically interested in the often overlooked element of a young firm’s ability (or lack thereof) to control its brand and brand identity as perceived by it
