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OBJECTIVES: To examine cardiovascular autonomic function in middle-aged people with long-term cervical and upper thoracic spinal cord injury (SCI) compared with the general population, and explore if the neurological level of injury (NLI) is related to cardiovascular autonomic function.DESIGN: Population-based cross-sectional study with matched controls.SETTING: Outpatient SCI unit in Southern Swe

Vaccine hesitancy (VH) is an issue for healthcare students, influenced by safety concerns and misinformation. The need for better communication training and understanding sociocultural factors in VH was highlighted in a European University Alliance seminar. Practical exercises like simulation role-playing, interprofessional collaboration, and digital literacy may improve vaccine education.

Improvements in colorectal cancer (CRC) detection and treatment have led to greater numbers of CRC survivors, for whom there is limited evidence on which to provide dietary guidelines to improve survival outcomes. Higher intake of red and processed meat and lower intake of fibre are associated with greater risk of developing CRC, but there is limited evidence regarding associations with survival a

Falsterbo Peninsula on the south coast of Sweden is low-lying and exposed to flooding. In 1872 the extreme storm surge Backafloden caused large devastation on the Swedish, Danish, and German coasts in the South Baltic Sea. For the Falsterbo Peninsula, the peak storm surge level is estimated to have been 240 cm above normal. If a similar event happened today, the consequences would be far worse, as

På senare år har det diskuterats frenetiskt om arbetet mot gängkriminaliteten. Inom ramen för regeringens 34-punktsprogram, ett program bestående av flera förslag till åtgärder mot gängkriminaliteten i Sverige, infördes en ny tillfällig lag som gäller under en femårsperiod. I april 2020 trädde lagen (2020:62) om hemlig dataavläsning i kraft, för att möjliggöra för de brottsbekämpande myndigheternaOver the past years in Sweden, there has been a lot of discussions concerning the struggle on gang-related misconduct. Enclosed in the framework of the Swedish government's 34-point program, moreover an agenda comprising several proposals for measures to combat gang-related criminality, a new temporary legislation was introduced for a period of five years. In April 2020, the Secret Data Interc

This thesis is about traditional and modern architecture in Casablanca, Morocco. Morocco is located in north-western Africa and Casablanca is the country's largest city with a population of 3.3 million (2011). Morocco has a long history with many different rulers which have left its mark on the country's architecture. The old, traditional architecture of Casablanca is in the old medina, Me

Wnt5a is a non-canonical secreted glycoprotein of the Wnt family that plays an important role in cancer development and progression. Previous studies report that Wnt5a is upregulated in prostate cancer and suggested that Wnt5a affects migration and invasion of prostate tumor cell. This study aimed to evaluate the prognostic value of Wnt5a protein expression in prostate cancer tissue and its potent

We aimed to characterize the genomic profiles of adenocarcinomas in the gastroesophageal junction in relation to cancers in the esophagus and the stomach. Profiles of gains/losses as well as gene expression profiles were obtained from 27 gastroesophageal adenocarcinomas by means of 32k high-resolution array-based comparative genomic hybridization and 27k oligo gene expression arrays, and putative

Malignant melanoma has the highest increase of incidence of malignancies in the western world. In early stages, front line therapy is surgical excision of the primary tumor. Metastatic disease has very limited possibilities for cure. Recently, several protein kinase inhibitors and immune modifiers have shown promising clinical results but drug resistance in metastasized melanoma remains a major pr

BACKGROUND: Changes in glycosylation of serum proteins are common, and various glycoforms are being explored as biomarkers in cancer and inflammation. We recently showed that glycoforms detected by endogenous galectins not only provide potential biomarkers, but also have different functions when they encounter galectins in tissue cells. Now we have explored the use of a combination of two galectin

Suppressor of cytokine signaling 2 (SOCS2) is known as a feedback inhibitor of cytokine signaling and is highly expressed in primary bone marrow (BM) cells from patients with chronic myeloid leukemia (CML). However, it has not been established whether SOCS2 is involved in CML, caused by the BCR/ABL1 fusion gene, or important for normal hematopoietic stem cell (HSC) function. In this study, we demo

Globally, malignant melanoma shows a steady increase in the incidence among cancer diseases. Malignant melanoma represents a cancer type where currently no biomarker or diagnostics is available to identify disease stage, progression of disease or personalized medicine treatment. The aim of this study was to assess the tissue expression of alpha-synuclein, a protein implicated in several disease pr

Popular Abstract in English Does subjectivism in value theory — the view that value is grounded on attitudes — imply that when we think and talk about what is good and bad we must necessarily be thinking and talking about our desires and other attitudes? Does value subjectivism entail that evaluative utterances are reports or expressions of the speaker’s attitude? Are subjectivists committed to anThe thesis examines a specific way of understanding the subjectivist position in value theory according to which subjectivism is the view that value is grounded on attitudes. It is argued that this should be seen as a second-order claim about the nature of value although with pluralistic implications on the substantial, first-order level. Subjectivist analyses of final and intrinsic value and of r

Studies of developmental pathways of hematopoietic stem cells (HSCs) have defined lineage relationships throughout the blood system. This is relevant to acute myeloid leukemia (AML), where aggressiveness and therapeutic responsiveness can be influenced by the initial stage of transformation. To address this, we generated a mouse model in which the mixed-lineage leukemia/eleven-nineteen-leukemia (M

Diabetes mellitus (DM) type II is increasing rapidly worldwide. Patients with DM II have a greater atherosclerotic burden and higher risk of developing cardiovascular complications. Inflammation has been proposed as the main cause for the high risk of atherosclerotic disease in DM II. In this study, we compared markers of inflammation and fibrous repair in plaques from subjects with and without DM

Studies on fibre intake and incident colorectal cancer (CRC) indicate inverse associations. Differences by tumour stage have not been examined. We examined associations between fibre intake and its sources, and incidental CRC. Separate analyses were carried out on the basis of sex, tumour location and the Tumour, Node, Metastasis (TNM) classification. The Malmö Diet and Cancer Study is a populatio

Variation in transcription factor 7-like 2 (TCF7L2), the strongest genetic risk factor for type 2 diabetes (T2D), may play a role in prostate cancer (PCa) depending on lifestyle factors. The aims of this study were to determine if TCF7L2 rs7903146 is associated with risk of PCa and if the association is modified by lifestyle factors independently of T2D status.

Appropriate regulation of hematopoietic stem cell (HSC) numbers and function is a requisite for life-long blood cell replenishment. Knowledge of factors that regulate HSC activity is derived largely from murine model systems, with serial transplantation often considered a "gold standard" to assess longevity and self-renewal of HSCs. In the literature, we noted inconsistencies in how serial transpl

Self-renewal of hematopoietic stem cells (HSCs) and leukemia-initiating cells (LICs) has been proposed to be influenced by low oxygen tension (hypoxia). This signaling, related to the cellular localization inside the bone marrow niche and/or influenced by extrinsic factors, promotes the stabilization of hypoxia inducible factors (HIFs). Whether HIF-1α can be used as a therapeutic target in the tre