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Lung cancer is the worldwide leading cause of death from cancer. Epigenetic modifications such as methylation and changes in chromatin accessibility are major gene regulatory mechanisms involved in tumorigenesis and cellular lineage commitment. We aimed to characterize these processes in the context of neuroendocrine (NE) lung cancer. Illumina 450K DNA methylation data were collected for 1407 lung
Chronic myeloid leukemia (CML) is currently treated with tyrosine kinase inhibitors, but these do not effectively eliminate the CML stem cells. As a consequence, CML stem cells persist and cause relapse in most patients upon drug discontinuation. Furthermore, no effective therapy exists for the advanced stages of the disease. Interleukin-1 receptor accessory protein (IL1RAP; IL1R3) is a coreceptor
Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion, but the mechanisms underlying insulin secretion failure are not completely understood. Here, we show that a set of co-expressed genes, which is enriched for genes with islet-selective open chromatin, is associated with T2D. These genes are perturbed in T2D and have a similar expression pattern to that of d
Occurring at rates up to 6-7 syllables per second, speech perception and understanding involves rapid identification of speech sounds and pre-activation of morphemes and words. Using event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI), we investigated the time-course and neural sources of pre-activation of word endings as participants heard the beginning of unfolding wOccurring at rates up to 6-7 syllables per second, speech perception and understanding involves rapid identification of speech sounds and pre-activation of morphemes and words. Using event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI), we investigated the time-course and neural sources of pre-activation of word endings as participants heard the beginning of unfolding w
PURPOSE: Free skin grafts are frequently used in reconstructive surgery. However, little is known about the course of reperfusion due to the previous lack of reliable perfusion monitoring techniques. The aim of this study was to use state-of-the-art laser speckle contrast imaging to monitor free skin grafts in the periocular area.METHODS: Seven patients needing surgery due to tumor removal or cica
Circular building design could significantly reduce the environmental impact of buildings and the pressure on natural resources. However, most buildings today are not designed according to the principles of the circular economy. Most literature has focused on either methods for quantifying the lifecycle analysis of buildings and materials, or on innovative circular building materials, but not much
The transcription factor hepatic leukemia factor (HLF) is strongly expressed in hematopoietic stem cells (HSCs) and is thought to influence both HSC self-renewal and leukemogenesis. However, the physiological role of HLF in hematopoiesis and HSC function is unclear. Here, we report that mice lacking Hlf are viable with essentially normal hematopoietic parameters, including an intact HSC pool durin
Pathogenesis of abdominal aortic aneurysm (AAA) is unclear. The aim of this study was to evaluate inflammatory and hemodynamic plasma biomarkers as predictors for AAA in the prospective longitudinal cohort of middle-aged individuals from the cardiovascular cohort of the Malmö Diet and Cancer Study ( n=5551; 1991-94). C-reactive protein, cystatin C, copeptin, N-terminal pro-B-type natriuretic pepti
PurposeIn early breast cancer (BC), five conventional biomarkers—estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2), Ki67, and Nottingham histologic grade (NHG)—are used to determine prognosis and treatment. We aimed to develop classifiers for these biomarkers that were based on tumor mRNA sequencing (RNA-seq), compare classification performance, a
In the struggle to reach the national environmental policy objectives, environmental compensation has emerged as a possible policy tool that may contribute to achieving the objectives. In Sweden, environmental compensation is legally mandated mainly in cases of exploitation within Natura 2000 areas and nature reserves, which is handled through the Swedish Environmental Code. In contrast, regulatorIn the struggle to reach the national environmental policy objectives, environmental compensation has emerged as a possible policy tool that may contribute to achieving the objectives. In Sweden, environmental compensation is legally mandated mainly in cases of exploitation within Natura 2000 areas and nature reserves, which is handled through the Swedish Environmental Code. In contrast, regulator
As explained in the methods-section, we chose to analyze the 2-year data in regard to inflammatory activity based on MRI and synovial biomarkers (and not earlier time points) as our aim was to capture patients that experienced "prolonged" or chronic inflammation, which may be regarded as a potential risk factor for osteoarthritis (OA) development. Virtually all patients of an acute injury cohort (
In Sweden social work with homeless people is dominated by “Treatment First” (or the staircase model). The Treatment First models weak results in combating homelessness has increased the interest for Housing First. In 2015 we started a participatory design-oriented research project in the City of Helsingborg in Sweden that aims to implement principles of Housing First in a social housing programme
Solid fuel fired fluidized bed (FB) boilers are common in combined heat and power (CHP) plants in district heating- and process industry. In this study, utilization of such FB boilers for production of syngas in dual fluidized bed gasifiers and subsequent catalytic biofuel production to substitute natural gas (SNG), methanol (MeOH) and Fischer-Tropsch fuel (FT) has been examined. Based on the hypo
Because incubation by birds is energetically costly, parents frequently trade off investment in incubation against self-maintenance. This can be manifested by a reduction in incubation temperature, which comes at high somatic costs for nestlings. The extent to which these costs constrain fitness is poorly understood. We incubated wild blue tit clutches at three biologically relevant temperatures a
Acute myeloid leukemia (AML) is associated with a poor survival rate, and there is an urgent need for novel and more efficient therapies, ideally targeting AML stem cells that are essential for maintaining the disease. The interleukin 1 receptor accessory protein (IL1RAP; IL1R3) is expressed on candidate leukemic stem cells in the majority of AML patients, but not on normal hematopoietic stem cell
I år var andra gången som Lunds universitet genomförde en universitetsgemensam pedagogisk utvecklingskonferens, första gången var 2007. Konferensen, som är ett samarrangemang mellan samtliga fakulteter och CED, har nu alltså blivit en återkommande aktivitet! Samhällsvetenskapliga fakulteten stod värd för årets konferens och dekanus Ann-Katrin Bäcklund sträckte vid invigningen fram en symbolisk sta
Popular Abstract in English Morphologically marked case is a salient Standard Arabic feature without parallel in Arabic dialects. As such it is a grammatical system learned by native speakers of Arabic through formal education. Case endings are traditionally regarded as an essential feature of Standard Arabic, but morphological case endings are used only sporadically in extemporaneous speech in foMorphologically marked case is a salient Standard Arabic feature without parallel in Arabic dialects. As such it is a grammatical system learned by native speakers of Arabic through formal education. Case endings are traditionally regarded as an essential feature of Standard Arabic, but morphological case endings are used only sporadically in extemporaneous speech in formal situations where Standa
We examined associations between food intakes and incident breast cancer, defined by estrogen receptor (ER) and progesterone receptor (PR) status in the Malmö Diet and Cancer cohort (17,000 women aged 45-73 yr). The hazard ratios (HRs) of ER+PR+ (n = 270), ER+PR- (n = 87), and ER-PR- (n = 61) tumors and all cancer (n = 544) were estimated after 10 yr of follow-up. In multivariate analysis of ER+PR
